scholarly journals Folic Acid Supplement Use and Increased Risk of Gestational Hypertension

Hypertension ◽  
2020 ◽  
Vol 76 (1) ◽  
pp. 150-156 ◽  
Author(s):  
Qian Li ◽  
Shangzhi Xu ◽  
Xi Chen ◽  
Xu Zhang ◽  
Xiating Li ◽  
...  
Keyword(s):  
Folic Acid ◽  
Family History ◽  
Risk Ratio ◽  
Gestational Hypertension ◽  
Significant Risk ◽  
High Dose ◽  
Supplement Use ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension

Current results regarding the effect of folic acid (FA) supplement use on gestational hypertension (GH) and preeclampsia are limited and inconsistent. We aimed to investigate whether FA supplement use was associated with GH and preeclampsia. Participants from the Tongji Maternal and Child Health Cohort with information on periconceptional FA supplement use and diagnosis of GH/preeclampsia were included (n=4853). Robust Poisson regression was used to assess the association of FA supplement use and GH and preeclampsia. Among the 4853 participants in this study, 1161 (23.9%) and 161 (3.3%) women were diagnosed with GH and preeclampsia, respectively. The risk ratio of developing GH was higher in women who used ≥800 µg/d FA supplement from prepregnancy through midpregnancy than nonusers (risk ratio, 1.33 [1.08–1.65]). After adjusting for social-demographic, reproductive, lifestyle factors, family history of hypertension, other supplement use, and gestational weight gain, the adverse association remained significant (risk ratio, 1.32 [1.06–1.64]). Restricting the analysis among women with normal weight, without family history of hypertension, and without gestational diabetes mellitus, the positive FA-GH association still existed. We did not find any significant association between FA supplement use and preeclampsia regardless of adjustment. High-dose (≥800 µg/d) FA supplement use from prepregnancy through midpregnancy was associated with increased risk of GH. Attention should be given to avoid the potential risk of GH due to inappropriate FA supplement use in women who are planning or capable of pregnancy.

scholarly journals Sympathetic reactivity in young women with a family history of hypertension

2015 ◽  
Vol 308 (8) ◽  
pp. H816-H822 ◽  
Author(s):  
Jody L. Greaney ◽  
Evan L. Matthews ◽  
Megan M. Wenner
Keyword(s):  
Young Adults ◽  
Family History ◽  
Young Women ◽  
Cold Pressor Test ◽  
Cold Pressor ◽  
Isometric Handgrip ◽  
Pressor Test ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension

Young adults with a family history of hypertension (+FH) have increased risk of developing hypertension. Furthermore, the blood pressure (BP) response to sympathoexcitatory stimuli in young adults can predict the future development of hypertension. Therefore, we hypothesized young women with a +FH would have exaggerated cardiovascular and sympathetic reactivity compared with young women without a family history of hypertension (−FH). Beat-by-beat mean arterial pressure (MAP) and muscle sympathetic nerve activity (MSNA) were measured in 14 women +FH (22 ± 1 yr, 21 ± 1 kg/m2, MAP 80 ± 2 mmHg) and 15 women −FH (22 ± 1 yr, 22 ± 1 kg/m2, MAP 78 ± 2 mmHg) during acute sympathoexcitatory maneuvers: cold pressor test, 2 min of isometric handgrip (HG) exercise at 30% of maximal voluntary contraction, and 3 min of postexercise ischemia (PEI; isolated activation of the skeletal muscle metaboreflex). During cold pressor test, the increase in BP was greater in women +FH (ΔMAP: +FH 16 ± 2 vs. −FH 11 ± 1 mmHg, P < 0.05), which was accompanied by an exaggerated increase in MSNA (ΔMSNA: +FH 17 ± 2 vs. −FH 8 ± 2 burst/min, P < 0.05). The increase in BP was greater in +FH during the last minute of HG (ΔMAP: +FH 23 ± 3 vs. −FH 12 ± 1 mmHg, P < 0.05) and during PEI (ΔMAP: +FH 17 ± 3 vs. −FH 9 ± 2 mmHg, P < 0.05). Similarly, the increase in MSNA was greater in +FH during both HG (ΔMSNA: +FH 12 ± 2 vs. −FH 6 ± 2 burst/min, P < 0.05) and PEI (ΔMSNA: +FH 16 ± 2 vs. −FH 4 ± 2 burst/min, P < 0.05). These data demonstrate that +FH women have greater BP and sympathetic reactivity compared with −FH women.

scholarly journals The Prevalence rate of Hypertension in Rural Population of Bangladesh

2012 ◽  
Vol 18 (1) ◽  
pp. 12-17 ◽  
Author(s):  
MA Rahim ◽  
MM Rahman ◽  
M Rahman ◽  
F Ahmed ◽  
J Chowdhury ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Family History ◽  
Rural Population ◽  
Prevalence Rate ◽  
Positive Family History ◽  
Significant Risk ◽  
Major Health Problem ◽  
History Of ◽  
Family History Of Hypertension

Background: The non-communicable diseases like hypertension, diabetes and asthma are emerging as a major health problem in Bangladesh. Recently, these are given high research priority by the Government of Bangladesh. The prevalence of hypertension is increasing rapidly, but there is no current study on prevalence of hypertension in rural population of Bangladesh. There are some studies conducted on prevalence of hypertension from mid 70's to late 90's. Those studies showed the prevalence of hypertension is increasing significantly in both urban and rural population. In rural population the prevalence of hypertension was in 23.6% 1. After that there is no population based study was conducted on prevalence of hypertension in rural population of Bangladesh. Methods: We measured blood pressure, body weight and height of 532 individuals at and above the age of 20 years (age range 20-70 years) of both sexes accept pregnant and those who were under medication of hypertension. We collected information about smoking, family history of hypertension, status of physical activity, diabetes, annual income etc. Result: The overall prevalence rate of hypertension was 30.64% (male 31.53% and female 29.36%). In the study, the blood pressure was measured in all study subjects. The mean blood pressure was higher in hypertensive participants than that of non hypertensive. The prevalence of hypertension (30.64%) observed in this study was higher than the previous study. In this study showed that with the increasing age more the prevalence of hypertension. The similar funding also observed in recent Indian study. Our study showed that the hypertension prevalence was high among people with high BMI and obesity, positive family history, smoking and less physical activity. Conclusion: The prevalence of hypertension in the rural population was found to be on the increased compare to previous reports of Bangladesh and other Asian studies. Advanced age, obesity, higher incomes, family history of hypertension, smoking and reduced physical activity were proved significant risk factors for hypertension, whereas, sex, occupation, showed no association with hypertension. DOI: http://dx.doi.org/10.3329/jdnmch.v18i1.12225 J. Dhaka National Med. Coll. Hos. 2012; 18 (01): 12-17

scholarly journals A Common Polymorphism G-50T in Cytochrome P450 2J2 Gene Is Associated with Increased Risk of Essential Hypertension in a Russian Population

2008 ◽  
Vol 24 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Alexey V. Polonikov ◽  
Vladimir P. Ivanov ◽  
Maria A. Solodilova ◽  
Irina V. Khoroshaya ◽  
Mikhail A. Kozhuhov ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Family History ◽  
Arachidonic Acid Metabolism ◽  
Russian Population ◽  
Common Polymorphism ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Polymerase Chain ◽  
First Time

The present study was designed to test whether common polymorphism G-50T within the promoter of humanCYP2J2gene is associated with increased risk of essential hypertension in a Russian population. We studied 576 unrelated subjects, including 295 patients with hypertension and 281 healthy subjects. Genotyping for polymorphism G-50T of theCYP2J2gene was performed by polymerase chain reaction and restriction fragment length polymorphism techniques. The frequency of a −50T variant allele ofCYP2J2gene was significantly higher in patients with hypertension versus healthy controls (OR 4.03 95%CI 1.80–9.04p=0.0004). The association of a −50GT genotype with hypertension remained significant after adjustment for age, gender and family history of hypertension by multivariate logistic regression (OR 4.78 95%CI 1.87–12.27p=0.001). It has been found that OR for −50GT genotype × gender interaction (OR 4.48 95%CI 1.93–10.39p=0.00048) was slightly higher than OR for −50GT genotype (OR 4.43 95%CI 1.91–10.29p=0.00052), suggesting a weak effect of gender on the risk of hypertension in the heterozygous carriers of −50GT genotype. A family history of hypertension has no effect on the association between a −50GT genotype and hypertension. In present study we demonstrate for the first time that aCYP2J2*7 allele of theCYP2J2gene is clearly associated with an increased risk of essential hypertension. Furthermore, this study highlights the importance of P-450 epoxygenase pathway of arachidonic acid metabolism in the pathogenesis of hypertensive disease.

scholarly journals Association and interaction of hemoglobin glycation index with hypertension risk: a community-based cross-sectional survey

2020 ◽  
Author(s):  
Jing Mi ◽  
Jian Song ◽  
Yingying Zhao ◽  
xue-sen wu
Keyword(s):  
Family History ◽  
Interactive Effect ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hemoglobin Glycation

Abstract BackgroundHemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals.Methods The eligible subjects were chosen from a community-based cross-sectional survey in China. We collected relevant data and clinical indicators for each participant. HGI was calculated as “measured HbA1c-predicted HbA1c” and divided into four categories according to quartile. The following indicators were used to assess interactive effects：(1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software.ResultsSpecifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (P<0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87(95%CI: 1.26-2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI:1.36,95%CI:0.11-2.63; AP: 0.43, 95%CI:0.17-0.69; and SI:2.68, 95% CI:1.10-6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95%CI:0.24-1.85), AP (0.33, 95% CI: 0.11-0.56) and SI (1.96, 95%CI:1.01-3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95%CI: 0.01-0.54) was observed to be significant.ConclusionHigh HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.

scholarly journals Association of hemoglobin glycation index and its interaction with obesity/family history of hypertension on hypertension risk: a community-based cross-sectional survey

2020 ◽  
Author(s):  
Jing Mi ◽  
Jian Song ◽  
Yingying Zhao ◽  
xue-sen wu
Keyword(s):  
Family History ◽  
Interactive Effect ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hemoglobin Glycation

Abstract BackgroundHemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals.Methods The eligible subjects were chosen from a community-based cross-sectional survey in China.We collected relevant data and clinical indicators for each participant. HGI was calculated as “measured HbA1c-predicted HbA1c” and divided into four categories according to quartile. The following indicators were used to assess interactive effects：(1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software.ResultsSpecifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (P<0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87(95%CI: 1.26-2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI:1.36,95%CI:0.11-2.63; AP: 0.43, 95%CI:0.17-0.69; and SI:2.68, 95% CI:1.10-6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95%CI:0.24-1.85), AP (0.33, 95% CI: 0.11-0.56) and SI (1.96, 95%CI:1.01-3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95%CI: 0.01-0.54) was observed to be significant.ConclusionHigh HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.

scholarly journals Association of hemoglobin glycation index and its interaction with obesity /family history of hypertension on hypertension risk: a community-based cross-sectional survey

2020 ◽  
Author(s):  
Jing Mi ◽  
Jian Song ◽  
Yingying Zhao ◽  
xue-sen wu
Keyword(s):  
Family History ◽  
Interactive Effect ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hemoglobin Glycation

Abstract Background: Hemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals.Methods : The eligible subjects were chosen from a community-based cross-sectional survey in China. We collected relevant data and clinical indicators for each participant. HGI was calculated as “measured HbA1c-predicted HbA1c” and divided into four categories according to quartile. The following indicators were used to assess interactive effects：(1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software.Results: Specifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (P<0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87(95%CI: 1.26-2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI:1.36,95%CI:0.11-2.63; AP: 0.43, 95%CI:0.17-0.69; and SI:2.68, 95% CI:1.10-6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95%CI:0.24-1.85), AP (0.33, 95% CI: 0.11-0.56) and SI (1.96, 95%CI:1.01-3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95%CI: 0.01-0.54) was observed to be significant.Conclusion: High HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.

scholarly journals Association of hemoglobin glycation index and its interaction with obesity/family history of hypertension on hypertension risk: a community-based cross-sectional survey

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jing Mi ◽  
Jian Song ◽  
Yingying Zhao ◽  
Xuesen Wu
Keyword(s):  
Family History ◽  
Interactive Effect ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hemoglobin Glycation

Abstract Background Hemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals. Methods The eligible subjects were chosen from a community-based cross-sectional survey in China. We collected relevant data and clinical indicators for each participant. HGI was calculated as “measured HbA1c-predicted HbA1c” and divided into four categories according to quartile. The following indicators were used to assess interactive effects: (1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software. Results Specifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (p < 0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87 (95% CI 1.26–2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI: 1.36, 95% CI 0.11–2.63; AP: 0.43, 95% CI 0.17–0.69; and SI:2.68, 95% CI 1.10–6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95% CI 0.24–1.85), AP (0.33, 95% CI 0.11–0.56) and SI (1.96, 95% CI 1.01–3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95% CI 0.01–0.54) was observed to be significant. Conclusion High HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.

scholarly journals Prevalence and Covariates of Undiagnosed Hypertension in the Adult Population of Puducherry, South India

2012 ◽  
Vol 2 (2) ◽  
pp. 191-99 ◽  
Author(s):  
DR Bharati ◽  
P Nandi ◽  
TV Yamuna ◽  
A Lokeshmaran ◽  
L Agarwal ◽  
...  
Keyword(s):  
Family History ◽  
Urban Area ◽  
Rural And Urban ◽  
Undiagnosed Hypertension ◽  
Increased Risk ◽  
Tobacco Addiction ◽  
History Of ◽  
Family History Of Hypertension ◽  
Sedentary Life ◽  
Rural And Urban Area

Background Globally the prevalence of both hypertension and pre-hypertension are increasing and pre-hypertension has been associated with higher cardiovascular risk. The objective of this study was to find out the prevalence of undiagnosed hypertension and pre-hypertension and associated covariates among adults of rural and urban area of Puducherry. Material and Methods A population based cross-sectional study was carried out in the field practices area of Department of Community Medicine, Mahatma Gandhi Medical College and Research Institute without intervention. Results Among 856 participants, 27.6 percent were hypertensive and 57 percent pre-hypertensive; the magnitude of both stage 1 and stage 2 hypertension increased with the age. Of the hypertensives, 26.3 and 28.7 percent were from rural and urban area respectively, whereas in pre-hypertension the corresponding figures were 61 and 53.4 percent.  Significantly increased risk of hypertension was noted among adults with increasing age, having less than six members in the family, suffering from obesity (general and abdominal obesity) and living sedentary life. On the other hand, the probability of having increased risk of pre-hypertension was significantly higher among adults living in the rural areas, having non-vegetarian dietary habit, suffering from obesity (general and abdominal obesity), living sedentary life and having family history of hypertension. Multivariate logistic regression however showed significant correlation of hypertension with increasing age, sedentary lifestyle, tobacco addiction and obesity (general and central). Significant correlates of pre-hypertensive were rural residence, sedentary living habits, family history of hypertension, tobacco addiction and obesity (general and central). Conclusion The present findings show high prevalence of hypertension and pre-hypertension among population of Puducherry in South India.DOI: http://dx.doi.org/10.3126/nje.v2i2.6576 Nepal Journal of Epidemiology 2012;2(2):191-199

scholarly journals The risk factors of gestational hypertension in patients with polycystic ovary syndrome: a retrospective analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shu Zhou ◽  
Yiping Ji ◽  
Haimei Wang
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Gestational Hypertension ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Contraceptive Pills ◽  
History Of ◽  
Independent Risk Factors ◽  
Family History Of Hypertension ◽  
Adverse Pregnancy

Abstract Background The hypertensive disorders complicating pregnancy (HDCP) is common in patients with polycystic ovary syndrome (PCOS), yet the potential influencing factors remained unclear. We aimed to assess the independent risk factors of HDCP in patients with PCOS, to provide clinical evidences for the management of PCOS. Methods Pregnant PCOS patients treated in our hospital from June 1, 2018 to November 30, 2020 were approached. The personal and clinical characteristics of patients with and without gestational hypertension were evaluated. Logistic regressions were conducted to identify the independent risk factors of HDCP, Receiver operating characteristics (ROC)curve analysis was conducted to evaluate the predicting value. Results A total of 188 PCOS patients were included, the incidence of HDCP in patients with PCOS was 27.66 %. There were significant differences in the age, BMI, family history of hypertension, the history of adverse pregnancy, history of contraceptive pills use and family history of HDCP between HDCP group and no-HDCP group (all p < 0.05), and there were no significant differences in the family history of diabetes, multiple pregnancy and long-term smoking history between HDCP group and no-HDCP group (all p > 0.05). Age ≥ 27y(OR2.048, 95 %CI1.121 ~ 3.208), BMI ≥ 24 kg/m2(OR1.463, 95 %CI1.069 ~ 2.011), family history of hypertension(OR2.129, 95 %CI1.093 ~ 3.042), the history of adverse pregnancy(OR2.435, 95 %CI1.264 ~ 4.085), history of contraceptive pills use(OR3.806, 95 %CI1.184 ~ 6.102), family history of HDCP(OR1.934, 95 %CI1.016 ~ 2.774) were the independent risk factors of HDCP in patients with PCOS (all p < 0.05). ROC curve analyses indicated that those factors had good predictive value on HDCP in PCOS patients. Conclusions The incidence of HDCP in PCOS patients is relatively high. In clinical practice, medical workers should carry out early prevention and intervention measures for these risk factors to reduce the incidence of HDCP.

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