ISDN2012_0184: The Onecut transcription factors participate in the differentiation and migration of distinct subsets of ventral interneurons in the developing spinal cord

2012 ◽  
Vol 30 (8) ◽  
pp. 673-673
Author(s):  
C. Francius ◽  
A. Harris ◽  
T. Hendricks ◽  
M. Goulding. ◽  
F. Clotman
Keyword(s):  
Spinal Cord ◽  
Transcription Factors ◽  
And Migration ◽  
Developing Spinal Cord

scholarly journals Onecut factors and Pou2f2 regulate the distribution of V2 interneurons in the mouse developing spinal cord

2018 ◽  
Author(s):  
Audrey Harris ◽  
Gauhar Masgutova ◽  
Amandine Collin ◽  
Mathilde Toch ◽  
Maria Hidalgo-Figueroa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Transcription Factors ◽  
Neural Circuits ◽  
B Cell Differentiation ◽  
Loss Of Function ◽  
Neuronal Identity ◽  
Spinal Interneuron ◽  
Embryonic Spinal Cord ◽  
And Migration ◽  
Developing Spinal Cord

AbstractAcquisition of proper neuronal identity and position is critical for the formation of neural circuits. In the embryonic spinal cord, cardinal populations of interneurons diversify into specialized subsets and migrate to defined locations within the spinal parenchyma. However, the factors that control interneuron diversification and migration remain poorly characterized. Here, we show that the Onecut transcription factors are necessary for proper diversification and distribution of the V2 interneurons in the developing spinal cord. Furthermore, we uncover that these proteins restrict and moderate the expression of spinal isoforms of Pou2f2, a transcription factor known to regulate B-cell differentiation. By gain- or loss-of-function experiments, we show that Pou2f2 contribute to regulate the position of V2 populations in the developing spinal cord. Thus, we uncovered a genetic pathway that regulates the diversification and the distribution of V2 interneurons during embryonic development.Significance statementIn this study, we identify the Onecut and Pou2f2 transcription factors as regulators of spinal interneuron diversification and migration, two events that are critical for proper CNS development.

scholarly journals Anteroposterior Wnt-RA Gradient Defines Adhesion and Migration Properties of Neural Progenitors in Developing Spinal Cord

2020 ◽  
Vol 15 (4) ◽  
pp. 898-911
Author(s):  
Mohammed R. Shaker ◽  
Ju-Hyun Lee ◽  
Si-Hyung Park ◽  
Joo Yeon Kim ◽  
Gi Hoon Son ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neural Progenitors ◽  
And Migration ◽  
Developing Spinal Cord

scholarly journals HoxD transcription factors define monosynaptic sensory-motor specificity in the developing spinal cord

Development ◽  
2021 ◽  
Author(s):  
Fumiyasu Imai ◽  
Mike Adam ◽  
S. Steven Potter ◽  
Yutaka Yoshida
Keyword(s):  
Spinal Cord ◽  
Transcription Factors ◽  
Motor Neuron ◽  
Sensory Neurons ◽  
Motor Neurons ◽  
Critical Role ◽  
Dendrite Morphology ◽  
Sensory Motor ◽  
Integral Role ◽  
Developing Spinal Cord

The specificity of monosynaptic connections between proprioceptive sensory neurons and their recipient spinal motor neurons depends on multiple factors, including motor neuron positioning and dendrite morphology, axon projection patterns of proprioceptive sensory neurons in the spinal cord, and the ligand-receptor molecules involved in cell-to-cell recognition. However, with few exceptions, the transcription factors engaged in this process are poorly characterized. We show here, that members of the HoxD family of transcription factors play a critical role in the specificity of monosynaptic sensory-motor connections. Mice lacking Hoxd9, Hoxd10, and Hoxd11 exhibit defects in locomotion but have no obvious defects in motor neuron positioning or dendrite morphology through the medio-lateral and rostro-caudal axes. However, we found that quadriceps motor neurons in these mice show aberrant axon development and receive inappropriate inputs from proprioceptive sensory axons innervating the obturator muscle. These genetic studies demonstrate that the HoxD transcription factors play an integral role in the synaptic specificity of monosynaptic sensory-motor connections in the developing spinal cord.

scholarly journals Dorsal commissural axon guidance in the developing spinal cord

2020 ◽  
Author(s):  
Sandy Alvarez ◽  
Supraja G. Varadarajan ◽  
Samantha J. Butler
Keyword(s):  
Spinal Cord ◽  
Axon Guidance ◽  
Commissural Axon ◽  
Developing Spinal Cord

scholarly journals Expression and Cellular Distribution of Ubiquitin in Response to Injury in the Developing Spinal Cord of Monodelphis domestica

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62120 ◽  
Author(s):  
Natassya M. Noor ◽  
Kjeld Møllgård ◽  
Benjamin J. Wheaton ◽  
David L. Steer ◽  
Jessie S. Truettner ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Monodelphis Domestica ◽  
Cellular Distribution ◽  
Developing Spinal Cord

First experience with chronic epidural spinal cord stimulation in Khanty-Mansi autonomous okrug — clinical observations

2021 ◽  
Vol LIII (2) ◽  
pp. 94-100
Author(s):  
Olga A. Bondarenko ◽  
Gaspar V. Gavrilov ◽  
Vadim A. Padurets ◽  
Roman V. Kasich
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Spinal Cord Stimulation ◽  
Pain Syndrome ◽  
Chronic Neuropathic Pain ◽  
Neuropathic Pain Syndrome ◽  
Epidural Stimulation ◽  
Cord Injury ◽  
Epidural Spinal Cord Stimulation ◽  
And Migration

Purpose of the work. The article is devoted to the first experience of epidural stimulation in the Khanty-Mansiysk Autonomous Okrug at the budgetary institution Surgut Clinical Trauma Hospital. Clinical examples are presented for two main indications for the application of this technique (disease of the operated spine, a consequence of spinal cord injury in combination with chronic neuropathic pain syndrome). Research methods. An assessment of the intensity of pain syndrome was given according to a visual analogue scale, the Pain Detect questionnaire; indicators of anxiety, depression on the HADS scale; quality of life according to the Oswestry questionnaire for a follow-up period of 6-12 months in patients with chronic epidural stimulation. Results. A positive assessment of the action during test neurostimulation was 63.3% (38 patients). Of the established permanent systems, a good result was achieved and persisted for 12 months or more in 96% (24 patients). It was necessary to change the stimulation parameters in 13% (3 patients). Revision of permanent systems was performed in 20% (5 patients), due to the progression of the degenerative-dystrophic process of the spine, damage and migration of system elements. Conclusions. Chronic epidural spinal cord stimulation has established itself as a personalized, highly effective, minimally invasive and safe method of treating chronic neuropathic pain syndromes. Multicomponent corrective action is of scientific interest and requires further study.

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