scholarly journals Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord

Development ◽  
2007 ◽  
Vol 134 (8) ◽  
pp. 1617-1629 ◽  
Author(s):  
M. Sugimori ◽  
M. Nagao ◽  
N. Bertrand ◽  
C. M. Parras ◽  
F. Guillemot ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Transcription Factors ◽  
Hlh Transcription Factors ◽  
Spatiotemporal Control ◽  
Developing Spinal Cord

scholarly journals HoxD transcription factors define monosynaptic sensory-motor specificity in the developing spinal cord

Development ◽  
2021 ◽  
Author(s):  
Fumiyasu Imai ◽  
Mike Adam ◽  
S. Steven Potter ◽  
Yutaka Yoshida
Keyword(s):  
Spinal Cord ◽  
Transcription Factors ◽  
Motor Neuron ◽  
Sensory Neurons ◽  
Motor Neurons ◽  
Critical Role ◽  
Dendrite Morphology ◽  
Sensory Motor ◽  
Integral Role ◽  
Developing Spinal Cord

The specificity of monosynaptic connections between proprioceptive sensory neurons and their recipient spinal motor neurons depends on multiple factors, including motor neuron positioning and dendrite morphology, axon projection patterns of proprioceptive sensory neurons in the spinal cord, and the ligand-receptor molecules involved in cell-to-cell recognition. However, with few exceptions, the transcription factors engaged in this process are poorly characterized. We show here, that members of the HoxD family of transcription factors play a critical role in the specificity of monosynaptic sensory-motor connections. Mice lacking Hoxd9, Hoxd10, and Hoxd11 exhibit defects in locomotion but have no obvious defects in motor neuron positioning or dendrite morphology through the medio-lateral and rostro-caudal axes. However, we found that quadriceps motor neurons in these mice show aberrant axon development and receive inappropriate inputs from proprioceptive sensory axons innervating the obturator muscle. These genetic studies demonstrate that the HoxD transcription factors play an integral role in the synaptic specificity of monosynaptic sensory-motor connections in the developing spinal cord.

scholarly journals Onecut factors and Pou2f2 regulate the distribution of V2 interneurons in the mouse developing spinal cord

2018 ◽  
Author(s):  
Audrey Harris ◽  
Gauhar Masgutova ◽  
Amandine Collin ◽  
Mathilde Toch ◽  
Maria Hidalgo-Figueroa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Transcription Factors ◽  
Neural Circuits ◽  
B Cell Differentiation ◽  
Loss Of Function ◽  
Neuronal Identity ◽  
Spinal Interneuron ◽  
Embryonic Spinal Cord ◽  
And Migration ◽  
Developing Spinal Cord

AbstractAcquisition of proper neuronal identity and position is critical for the formation of neural circuits. In the embryonic spinal cord, cardinal populations of interneurons diversify into specialized subsets and migrate to defined locations within the spinal parenchyma. However, the factors that control interneuron diversification and migration remain poorly characterized. Here, we show that the Onecut transcription factors are necessary for proper diversification and distribution of the V2 interneurons in the developing spinal cord. Furthermore, we uncover that these proteins restrict and moderate the expression of spinal isoforms of Pou2f2, a transcription factor known to regulate B-cell differentiation. By gain- or loss-of-function experiments, we show that Pou2f2 contribute to regulate the position of V2 populations in the developing spinal cord. Thus, we uncovered a genetic pathway that regulates the diversification and the distribution of V2 interneurons during embryonic development.Significance statementIn this study, we identify the Onecut and Pou2f2 transcription factors as regulators of spinal interneuron diversification and migration, two events that are critical for proper CNS development.

scholarly journals Dorsal commissural axon guidance in the developing spinal cord

2020 ◽  
Author(s):  
Sandy Alvarez ◽  
Supraja G. Varadarajan ◽  
Samantha J. Butler
Keyword(s):  
Spinal Cord ◽  
Axon Guidance ◽  
Commissural Axon ◽  
Developing Spinal Cord

scholarly journals Expression and Cellular Distribution of Ubiquitin in Response to Injury in the Developing Spinal Cord of Monodelphis domestica

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62120 ◽  
Author(s):  
Natassya M. Noor ◽  
Kjeld Møllgård ◽  
Benjamin J. Wheaton ◽  
David L. Steer ◽  
Jessie S. Truettner ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Monodelphis Domestica ◽  
Cellular Distribution ◽  
Developing Spinal Cord

scholarly journals Minocycline attenuates ethanol-induced cell death and microglial activation in the developing spinal cord

Alcohol ◽  
2019 ◽  
Vol 79 ◽  
pp. 25-35 ◽  
Author(s):  
Zhenhua Ren ◽  
Xin Wang ◽  
Mei Xu ◽  
Jacqueline A. Frank ◽  
Jia Luo
Keyword(s):  
Spinal Cord ◽  
Cell Death ◽  
Microglial Activation ◽  
Developing Spinal Cord
Sign in / Sign up

Export Citation Format

Share Document