Acetylcholinesterase gene polymorphism and recurrent pregnancy loss

2009 ◽  
Vol 106 (1) ◽  
pp. 68-69
Author(s):  
Farah Parveen ◽  
Gaurav Tripathi ◽  
Bhanumati Singh ◽  
Rehan M. Faridi ◽  
Suraksha Agrawal
Keyword(s):  
Gene Polymorphism ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Acetylcholinesterase Gene

scholarly journals Detection of plasminogen activator inhibitor-1 (-675 4G/5G) gene polymorphism in women with recurrent abortion

2019 ◽  
Vol 7 (2) ◽  
pp. 41-44
Author(s):  
Iglal Youssef Shaala ◽  
Akram Abdel Moneim Deghady ◽  
 Reham Abdel Haleem Abo Elwafa ◽  
Tamer Ahmed Hosny ◽  
Engy Taher Ammar
Keyword(s):  
Gene Polymorphism ◽  
Plasminogen Activator ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Plasminogen Activator Inhibitor ◽  
Recurrent Abortion ◽  
Plasminogen Activator Inhibitor 1 ◽  
Uterine Anomalies ◽  
Activator Inhibitor ◽  
Pai 1

Background: recurrent abortion is considered one of the most common complications that occur during pregnancy and counts for 15% of pregnancies that are recognized clinically. Many causes can be attributed to the recurrent pregnancy loss e.g. chromosomal anomalies, thrombophilic disorders, uterine anomalies, endocrine abnormalities and fetal anomalies. Thrombophilia can be either hereditary or acquired. Multiple genes had been implicated in the pathogenesis of the thrombophilia. Previous studies have indicated that genetic polymorphism of the plasminogen activator inhibitor-1 gene (PAI-1) may be associated with recurrent abortion. Aim: The aim of the present study was to investigate whether plasminogen activator inhibitor-1 (-675 4G/5G) gene polymorphism is associated with the occurrence of recurrent pregnancy loss or not. Methods: DNA samples were collected from sixty six female patients with recurrent abortion (33 primary abortion, 33 secondary abortion) and thirty four healthy controls with normal pregnancy for detection of plasminogen activator inhibitor-1 (-675 4G/5G) gene polymorphism by restriction fragment length polymorphism PCR. Results: there was a significant association between PAI-1(-675 4G/5G) polymorphism and the occurrence of recurrent pregnancy loss. Conclusion: Our results assumed that PAI-1 (-675 4G/5G) polymorphism is associated with recurrent pregnancy loss.

Association of the protein Z intron F G79A gene polymorphism with recurrent pregnancy loss

2008 ◽  
Vol 90 (4) ◽  
pp. 1155-1160 ◽  
Author(s):  
Astrid Dossenbach-Glaninger ◽  
Michael van Trotsenburg ◽  
Hanns Helmer ◽  
Christian Oberkanins ◽  
Pierre Hopmeier
Keyword(s):  
Gene Polymorphism ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Protein Z

Interleukin-4 Gene Polymorphism is not Involved in the Risk of Recurrent Pregnancy Loss

2004 ◽  
Vol 52 (2) ◽  
pp. 143-146 ◽  
Author(s):  
Yasuaki Saijo ◽  
Fumihiro Sata ◽  
Hideto Yamada ◽  
Tomoko Konodo ◽  
Emi Hirayama Kato ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Interleukin 4

Role of miRNA polymorphism in recurrent pregnancy loss: a systematic review and meta-analysis

2022 ◽  
Author(s):  
Priyanka Srivastava ◽  
Chitra Bamba ◽  
Seema Chopra ◽  
Kausik Mandal
Keyword(s):  
Systematic Review ◽  
Data Mining ◽  
Gene Polymorphism ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Meta Analysis ◽  
Mirna Gene ◽  
Population Heterogeneity ◽  
Cochrane Library

There are a plethora of publications on the role of miRNA gene polymorphism and its association with recurrent pregnancy loss (RPL), but a lack of uniformity in the studies available due to the variable subject population, heterogeneity and contrary results of significance. Rigorous data mining was done through PubMed, SCOPUS, Cochrane library, Elsevier and Google Scholar to extract the studies of interest published until June 2021. A total of eight SNPs of miRNAs have been included, where ≥2 studies per SNPs were available. Analysis was done on the basis of pooled odds ratios and 95% CI. This is the first meta-analysis on miRNA SNPs in RPL that suggests that rs11614913, rs3746444 and rs2292832 biomarkers may decrease the risk of RPL under different genetic models.

Sign in / Sign up

Export Citation Format

Share Document