scholarly journals Clinical characteristics of patients hospitalized for acute respiratory infection associated with Influenza Virus

2018 ◽  
Vol 73 ◽  
pp. 268-269
Author(s):  
A.M. Rojas Rios ◽  
F.A. Gerbeno ◽  
S. Penco ◽  
S. Moreno ◽  
G. Martin
Keyword(s):  
Influenza Virus ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Clinical Characteristics

scholarly journals SARS-CoV-2 and influenza virus coinfection among patients with severe acute respiratory infection during the first wave of COVID-19 pandemic in Bangladesh: a hospital-based descriptive study

BMJ Open ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. e053768
Author(s):  
Zubair Akhtar ◽  
Md Ariful Islam ◽  
Mohammad Abdul Aleem ◽  
Syeda Mah-E-Muneer ◽  
M Kaousar Ahmmed ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Hospital Mortality ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Descriptive Study ◽  
Tertiary Level ◽  
Future Studies ◽  
Severe Acute Respiratory Infection ◽  
Hospital Deaths ◽  
Secondary Outcomes

ObjectiveTo estimate the proportion of SARS-CoV-2 and influenza virus coinfection among severe acute respiratory infection (SARI) cases-patients during the first wave of COVID-19 pandemic in Bangladesh.DesignDescriptive study.SettingNine tertiary level hospitals across Bangladesh.ParticipantsPatients admitted as SARI (defined as cases with subjective or measured fever of ≥38 C° and cough with onset within the last 10 days and requiring hospital admission) case-patients.Primary and secondary outcomesProportion of SARS-CoV-2 and influenza virus coinfection and proportion of mortality among SARI case-patients.ResultsWe enrolled 1986 SARI case-patients with a median age: 28 years (IQR: 1.2–53 years), and 67.6% were male. Among them, 285 (14.3%) were infected with SARS-CoV-2; 175 (8.8%) were infected with the influenza virus, and five (0.3%) were coinfected with both viruses. There was a non-appearance of influenza during the usual peak season (May to July) in Bangladesh. SARS-CoV-2 infection was significantly more associated with diabetes (14.0% vs 5.9%, p<0.001) and hypertension (26.7% vs 11.5%, p<0.001). But influenza among SARI case-patients was significantly less associated with diabetes (4.0% vs 7.4%, p=0.047) and hypertension (5.7% vs 14.4%, p=0.001). The proportion of in-hospital deaths among SARS-CoV-2 infected SARI case-patients were higher (10.9% (n=31) vs 4.4% (n=75), p<0.001) than those without SARS-CoV-2 infection; the proportion of postdischarge deaths within 30 days was also higher (9.1% (n=25) vs 4.6% (n=74), p=0.001) among SARS-CoV-2 infected SARI case-patients than those without infection. No in-hospital mortality or postdischarge mortality was registered among the five coinfected SARI case-patients.ConclusionsOur findings suggest that coinfection with SARS-CoV-2 and influenza virus was not very common and had less disease severity considering mortality in Bangladesh. There was no circulating influenza virus during the influenza peak season during the COVID-19 pandemic in 2020. Future studies are warranted for further exploration.

scholarly journals Viral etiology in adult influenza-like illness/acute respiratory infection and predictivity of C-reactive protein

2016 ◽  
Vol 10 (07) ◽  
pp. 741-746 ◽  
Author(s):  
Hakan Cinemre ◽  
Cengiz Karacer ◽  
Murat Yücel ◽  
Aziz Öğütlü ◽  
Fatma Behice Cinemre ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Respiratory Infection ◽  
Bordetella Pertussis ◽  
Legionella Pneumophila ◽  
Acute Respiratory Infection ◽  
Influenza A ◽  
Chlamydia Pneumoniae ◽  
Influenza Virus Infection ◽  
Antibiotic Use ◽  
Influenza Like Illness

Introduction: Influenza-like illness (ILI) and acute respiratory infection (ARI) are common presentations during winter and indiscriminate antibiotic use contributes significantly to the emerging post-antibiotic era. Methodology: Otherwise healthy 152 patients, presenting to outpatient clinics with ILI/ARI, were included. Patients had history & physical, CRP, hemogram and nasopharyngeal swabs for rhinovirus A/B, influenza A/B, adenovirus A/B/C/D/E, coronavirus 229E/NL63 and OC43, parainfluenza virus 1/2/3, respiratory syncytial virusA/B, metapneumovirus and Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella pneumophila and Bordetella pertussis by PCR and for ABHS culture. Results: Median (IR) age was 26.5 (16.5). Time to presentation was shorter in men (p = 0.027). Patients with rhinovirus had lower rates (20%) of myalgia (p = 0.043). Patients with influenza virus had higher rates (97%) of elevated CRP (p = 0.016). Logistic regression revealed that patients with ILI/ARI and CRP ≥ 5 mg/L were 60 times more likely to have influenza virus infection than other viral agents (OR = 60.0, 95% CI = 2.65 to 1,358.2, p = 0.010). Rhinovirus predominated in December (54%), March (36%), and April (33%). Influenza virus predominated in January (51%). Fever was most common with adenovirus (p = 0.198). All GABHS cultures were negative. Atypical organisms and Bordetella pertussis were negative in all but one patient. Conclusions: Influenza virus is the most likely pathogen in ILI/ARI when CRP ≥ 5 mg/L. This might be explained by tissue destruction. Myalgia is rare with rhinovirus probably due to absence of viremia. Negative bacteria by PCR and culture suggest unnecessary antibiotic use in ILI/ARI.

scholarly journals Clinical characteristics of influenza virus-induced lower respiratory infection during the 2015 to 2016 season

2018 ◽  
Vol 24 (6) ◽  
pp. 407-413 ◽  
Author(s):  
Kazuhiro Uda ◽  
Kensuke Shoji ◽  
Chitose Koyama-Wakai ◽  
Munehiro Furuichi ◽  
Noriyasu Iwase ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Respiratory Infection ◽  
Clinical Characteristics ◽  
Lower Respiratory Infection

scholarly journals Moderate Vaccine Effectiveness against Severe Acute Respiratory Infection Caused by A(H1N1)pdm09 Influenza Virus and No Effectiveness against A(H3N2) Influenza Virus in the 2018/2019 Season in Italy

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 427 ◽  
Author(s):  
Caterina Rizzo ◽  
Francesco Gesualdo ◽  
Daniela Loconsole ◽  
Elisabetta Pandolfi ◽  
Antonino Bella ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Vaccine Coverage ◽  
Type A ◽  
Vaccine Effectiveness ◽  
Influenza Viruses ◽  
Severe Acute Respiratory Infection ◽  
H3n2 Influenza ◽  
Subtype A

Every season, circulating influenza viruses change; therefore, vaccines must be reformulated each year. We aimed to estimate vaccine effectiveness (VE) against severe influenza infection for the 2018/19 season in Italy. We conducted a test-negative design case-control study at five Italian hospitals. We estimated influenza VE against severe acute respiratory infection (SARI) requiring hospitalisation overall, and by virus subtype, vaccine brand, and age. The 2018/19 season was characterised by A(H1N1)pmd09 and A(H3N2) influenza viruses. Vaccine coverage among <18 years recruited SARI cases was very low (3.2%). Seasonal vaccines were moderately effective against type A influenza overall (adjusted VE = 40.5%; 95% confidence interval (CI) = 18.7–56.4%) and subtype A(H1N1)pmd09 viruses (adjusted VE = 55%; 95% CI = 34.5–69.1%), but ineffective against subtype A(H3N2) viruses (adjusted VE = 2.5%; 95% CI = −50.0–36.7%). Both Fluad and Fluarix Tetra vaccines were effective against type A influenza overall and subtype A(H1N1)pdm09 viruses. VE appeared to be similar across age groups (0–64 years, ≥65 years). Seasonal influenza vaccines in the 2018/19 season were moderately effective in preventing SARI caused by A(H1N1)pdm09 influenza but ineffective against A(H3N2).

Prevalence of influenza virus types A and B in patients with acute respiratory infection: 2002–2015

2016 ◽  
Vol 82 ◽  
pp. S128 ◽  
Author(s):  
Candan Cicek ◽  
Eylem Ulas Saz ◽  
Haydar Soydaner Karakus ◽  
Husnu Pullukcu
Keyword(s):  
Influenza Virus ◽  
Respiratory Infection ◽  
Acute Respiratory Infection

scholarly journals Etiological and epidemiological characteristics of severe acute respiratory infection caused by multiple viruses and Mycoplasma pneumoniae in adult patients in Jinshan, Shanghai: A pilot hospital-based surveillance study

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248750 ◽  
Author(s):  
Jian Li ◽  
Can-Lei Song ◽  
Tang Wang ◽  
Yu-Long Ye ◽  
Jian-Ru Du ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Mycoplasma Pneumoniae ◽  
Active Surveillance ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Adult Patients ◽  
Chronic Medical Condition ◽  
Human Bocavirus ◽  
Influenza Virus A ◽  
Severe Acute Respiratory Infection

Background Severe acute respiratory infection (SARI) results in a tremendous disease burden worldwide. Available research on active surveillance among hospitalized adult patients suffering from SARI in China is limited. This pilot study aimed to identify associated etiologies and describe the demographic, epidemiological and clinical profiles of hospitalized SARI patients aged over 16 years in Jinshan, Shanghai. Methods Active surveillance was conducted at 1 sentinel hospital in Jinshan district, Shanghai, from April 2017 to March 2018. Hospitalized SARI patients aged over 16 years old were enrolled, and nasopharyngeal swabs were collected within 24 hours of admission and tested for multiple respiratory viruses (including 18 common viruses) and Mycoplasma pneumoniae with real-time polymerase chain reaction. Demographic, epidemiological and clinical information was obtained from case report forms. Results In total, 397 SARI patients were enrolled; the median age was 68 years, and 194 (48.9%) patients were male. A total of 278 (70.0%) patients had at least one underlying chronic medical condition. The most frequent symptoms were cough (99.2%) and sputum production (88.4%). The median duration of hospitalization was 10 days. A total of 250 infection patients (63.0%) were positive for at least one pathogen, of whom 198 (49.9%) were positive for a single pathogen and 52 (13.1%) were positive for multiple pathogens. The pathogens identified most frequently were M. pneumoniae (23.9%, 95/397), followed by adenovirus (AdV) (11.6%, 46/397), influenza virus A/H3N2 (Flu A/H3N2) (11.1%, 44/397), human rhinovirus (HRhV) (8.1%, 32/397), influenza virus B/Yamagata (Flu B/Yamagata) (6.3%, 25/397), pandemic influenza virus A/H1N1 (Flu A/pH1N1) (4.0%, 16/397), parainfluenza virus (PIV) type 1 (2.0%, 8/397), human coronavirus (HCoV) type NL63 (2.0%, 8/397), HCoV 229E (1.5%, 6/397), HCoV HKU1 (1.5%, 6/397), PIV 3 (1.5%, 6/397), human metapneumovirus (HMPV) (1.5%, 6/397), PIV 4 (1.3%, 5/397), HCoV OC43 (1.0%, 4/397), influenza virus B/Victoria (Flu B/Victoria) (0.5%, 2/397), respiratory syncytial virus (RSV) type B (0.5%, 2/397), and human bocavirus (HBoV) (0.3%, 1/397). The seasonality of pathogen-confirmed SARI patients had a bimodal distribution, with the first peak in the summer and the second peak in the winter. Statistically significant differences were observed with respect to the rates of dyspnea, radiographically diagnosed pneumonia and the presence of at least one comorbidity in patients who were infected with only M. pneumoniae, AdV, HRhV, Flu A/H3N2, Flu A /pH1N1 or Flu B/Yamagata. The differences in the positivity rates of the above 6 pathogens among the different age groups were nonsignificant. Conclusions M. pneumoniae, AdV and Flu A/H3N2 were the main pathogens detected in hospitalized SARI patients aged over 16 years old in Jinshan district, Shanghai. Our findings highlight the importance of sustained multipathogen surveillance among SARI patients in sentinel hospitals, which can provide useful information on SARI etiologies, epidemiology, and clinical characteristics.

Sign in / Sign up

Export Citation Format

Share Document