Effectiveness of a multi-layer silicone-adhesive polyurethane foam dressing as prevention for sacral pressure ulcers in at-risk in-patients: randomized controlled trial

Abstract Background Despite being considered preventable, ulcers due to pressure affect between 30 and 50% of patients at high and very high risk and susceptibility, especially those hospitalized under critical care. Despite a lack of evidence over the efficacy in prevention against ulcers due to pressure, hourly repositioning in critical care as an intervention is used with more or less frequency to alleviate pressure on patients’ tissues. This brings up the objective of our study, which is to evaluate the efficacy in prevention of ulcers due to pressure acquired during hospitalization, specifically regarding two frequency levels of repositioning or manual posture switching in adults hospitalized in different intensive care units in different Colombian hospitals. Methods A nurse-applied cluster randomized controlled trial of parallel groups (two branches), in which 22 eligible ICUs (each consisting of 150 patients), will be randomized to a high-frequency level repositioning intervention or to a conventional care (control group). Patients will be followed until their exit from each cluster. The primary result of this study is originated by regarding pressure ulcers using clusters (number of first ulcers per patient, at the early stage of progression, first one acquired after admission for 1000 days). The secondary results include evaluating the risk index on the patients’ level (Hazard ratio, 95% IC) and a description of repositioning complications. Two interim analyses will be performed through the course of this study. A statistical difference between the groups < 0.05 in the main outcome, the progression of ulcers due to pressure (best or worst outcome in the experimental group), will determine whether the study should be put to a halt/determine the termination of the study. Conclusion This study is innovative in its use of clusters to advance knowledge of the impact of repositioning as a prevention strategy against the appearance of ulcers caused by pressure in critical care patients. The resulting recommendations of this study can be used for future clinical practice guidelines in prevention and safety for patients at risk. Trial registration PENFUP phase-2 was Registered in Clinicaltrials.gov (NCT04604665) in October 2020.

Download Full-text

Cognitive behavioural social skills training: Methods of a randomized controlled trial for youth at risk of psychosis

Early Intervention in Psychiatry ◽

10.1111/eip.13102 ◽

2021 ◽

Author(s):

Jean Addington ◽

Lu Liu ◽

Olga Santesteban‐Echarri ◽

Kali Brummitt ◽

Amy Braun ◽

...

Keyword(s):

At Risk ◽

Randomized Controlled Trial ◽

Social Skills ◽

Social Skills Training ◽

Controlled Trial ◽

Skills Training ◽

Training Methods ◽

Randomized Controlled ◽

Cognitive Behavioural ◽

Youth At Risk

Download Full-text

A randomized controlled trial evaluating the effectiveness of a web-based, computer-tailored self-management intervention for people with or at risk for COPD

International Journal of Chronic Obstructive Pulmonary Disease ◽

10.2147/copd.s81295 ◽

2015 ◽

pp. 1061 ◽

Cited By ~ 22

Author(s):

Viola Voncken-Brewster ◽

Huibert Tange ◽

Hein de Vries ◽

Zsolt Nagykaldi ◽

Bjorn Winkens ◽

...

Keyword(s):

At Risk ◽

Randomized Controlled Trial ◽

Controlled Trial ◽

Self Management ◽

Web Based ◽

Management Intervention ◽

Randomized Controlled

Download Full-text

A Three-Month Consumption of Eggs Enriched with ω-3, ω-5 and ω-7 Polyunsaturated Fatty Acids Significantly Decreases the Waist Circumference of Subjects at Risk of Developing Metabolic Syndrome: A Double-Blind Randomized Controlled Trial

Nutrients ◽

10.3390/nu13020663 ◽

2021 ◽

Vol 13 (2) ◽

pp. 663

Author(s):

Monique T. Ngo Njembe ◽

Barbara Pachikian ◽

Irina Lobysheva ◽

Nancy Van Overstraeten ◽

Louis Dejonghe ◽

...

Keyword(s):

Metabolic Syndrome ◽

At Risk ◽

Randomized Controlled Trial ◽

Waist Circumference ◽

Controlled Trial ◽

Density Lipoprotein ◽

Test Group ◽

Double Blind ◽

Randomized Controlled ◽

The Metabolic Syndrome

Alpha-linolenic acid (ALA), docosahexaenoic acid (DHA), rumenic acid (RmA), and punicic acid (PunA) are claimed to influence several physiological functions including insulin sensitivity, lipid metabolism and inflammatory processes. In this double-blind randomized controlled trial, we investigated the combined effect of ALA, DHA, RmA and PunA on subjects at risk of developing metabolic syndrome. Twenty-four women and men were randomly assigned to two groups. Each day, they consumed two eggs enriched with oleic acid (control group) or enriched with ALA, DHA, RmA, and PunA (test group) for 3 months. The waist circumference decreased significantly (−3.17 cm; p < 0.001) in the test group. There were no major changes in plasma insulin and blood glucose in the two groups. The dietary treatments had no significant effect on endothelial function as measured by peripheral arterial tonometry, although erythrocyte nitrosylated hemoglobin concentrations tended to decrease. The high consumption of eggs induced significant elevations in plasma low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol (p < 0.001), which did not result in any change in the LDL/HDL ratio in both groups. These results indicate that consumption of eggs enriched with ALA, DHA, RmA and PunA resulted in favorable changes in abdominal obesity without affecting other factors of the metabolic syndrome.

Download Full-text