Oral drug dosage forms administered to hospitalized children: Analysis of 117,665 oral administrations in a French paediatric hospital over a 1-year period.

The Fast Dissolving Drug Delivery Systems sets a new benchmark was an expansion that came into existence in the early 1980’s and combat over the use of the different dosage form like tablets, suspension, syrups, capsules which are the other oral drug delivery systems. Fast Dissolving Drug Delivery System (FDTS) has a major advantage over the conventional dosage forms since the drug gets rapidly disintegrated and dissolves in the saliva without the use of water .In spite of the downside lack of immediate onset of action; these oral dosage forms have valuable purposes such as self medication, increased patient compliance, ease of manufacturing and lack of pain. Hence Fast Disintegrating Tablets (FDTS) technology has been gaining importance now-a-days with wide variety of drugs serving many purposes. Fast Disintegrating Tablets (FDTS) has ever increased their demand in the last decade since they disintegrate in saliva in less than a minute that improved compliance in pediatrics and geriatric patients, who have difficulty in swallowing tablets or liquids. As fast dissolving tablet provide instantaneous disintegration after putting it on tongue, thereby rapid drug absorption and instantaneous bioavailability, whereas Fast dissolving oral films are used as practical alternative to FDTS. These films have a potential to deliver the drug systemically through intragastric, sublingual or buccal route of administration and also has been used for local action. In present review article different aspects of fast dissolving tablets and films like method of preparations, latest technologies, evaluation parameters are discussed. This study will be useful for the researchers for their lab work.

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SOLID DISPERSIONS: A METHOD TO IMPROVE BIOAVAILABILITY OF ORAL DRUG DOSAGE FORM

Journal of Biomedical and Pharmaceutical Research ◽

10.32553/jbpr.v8i3.592 ◽

2019 ◽

Vol 8 (3) ◽

Author(s):

Ritika Puri ◽

Manisha Bhatti

Keyword(s):

Solid Dispersion ◽

Solid Dispersions ◽

Aqueous Solubility ◽

Systemic Circulation ◽

Drug Dosage ◽

Oral Drug ◽

Surface Active Agents ◽

Drug Dosage Form ◽

Surface Active ◽

Biopharmaceutical Classification System

Presently only few percent of drugs having high aqueous solubility, Number of drugs are belonging to biopharmaceutical classification system class II that means possessing poor aqueous solubility eventually results in low level of drug in systemic circulation. To overcome this problem, various strategies have been come out into notion such as self emulsifying drug delivery system solid dispersions, use of surface active agents, complex formation. Solid dispersions is found to be promising approach to increase bioavailability by use of various polymers. This review focuses on the mechanism of drug release from solid dispersion with its method of preparation and applications. Key words: dissolution, particle size, solid dispersion

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REVIEW ON GASTRORETENTIVE DRUG DELIVERY SYSTEM

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i12.37264 ◽

2020 ◽

pp. 38-45

Author(s):

MANDAR J BHANDWALKAR ◽

PRASAD S DUBAL ◽

AKASH K.TUPE ◽

SUPRIYA N MANDRUPKAR

Keyword(s):

Drug Delivery ◽

Small Intestine ◽

Drug Delivery System ◽

Residence Time ◽

Delivery System ◽

Oral Drug Delivery ◽

Dosage Forms ◽

Oral Dosage ◽

Oral Drug ◽

Low Solubility

In recent years, gastroretentive drug delivery system (GRDDS) has gained researcher’s interest in the field of oral drug delivery. Various GRDDS approaches can be utilized to retain the dosage forms in the stomach and to release the drug slowly for an extended period of time. GRDDS can be used to prolong the residence time of delivery system in the stomach. This results in targeting of drug release at a specific site for the systemic or local effects. GRDDS can be used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. The challenges include fast gastric emptying of the dosage form which results in the poor bioavailability of the drug. Prolongation of the retention of drugs in stomach those having low solubility at high intestinal pH improves the solubility of drugs. GRDDS has proved to be effective in systemic actions as well as in local actions to treat gastric or duodenal ulcers. Local activity in the upper part of the small intestine can be obtained by improving the residence time of delivery system in the stomach. The system is useful for drugs which are unstable in the intestine or having a low solubility/permeability in the small intestine. Various GRDDS approaches include high density (sinking) systems, low-density (floating systems), mucoadhesive, expandable, unfoldable, superporous hydrogel systems, and magnetic systems.

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Figure 1: Recommendations for Compounding and Handling Noninjectable Hazardous Drug Dosage Forms

Competence Assessment for Compounding Hazardous Drugs eReport ◽

10.37573/9781585285945.009 ◽

2017 ◽

pp. 8-8

Keyword(s):

Drug Dosage ◽

Dosage Forms

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Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning

Chemical Engineering Journal ◽

10.1016/j.cej.2018.05.188 ◽

2018 ◽

Vol 350 ◽

pp. 290-299 ◽

Cited By ~ 33

Author(s):

Attila Balogh ◽

András Domokos ◽

Balázs Farkas ◽

Attila Farkas ◽

Zsolt Rapi ◽

...

Keyword(s):

Drug Dosage ◽

Dosage Forms ◽

Flow Synthesis ◽

End To End

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Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2019.105109 ◽

2020 ◽

Vol 142 ◽

pp. 105109 ◽

Cited By ~ 3

Author(s):

Ivana Pantelić ◽

Milica Lukić ◽

Gordana Gojgić-Cvijović ◽

Dragica Jakovljević ◽

Ines Nikolić ◽

...

Keyword(s):

Bacillus Licheniformis ◽

Drug Dosage ◽

Dosage Forms ◽

Pharmaceutical Application

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P08 Is there a difference in the frequency of manipulated orally and rectally administered medicines to paediatric in-patients in Sweden in the year 2009 and 2018 respectively? A register study

Archives of Disease in Childhood ◽

10.1136/archdischild-2019-esdppp.47 ◽

2019 ◽

Vol 104 (6) ◽

pp. e20.2-e20

Author(s):

A Andersson ◽

S Eksborg ◽

S Lindemalm ◽

U Förberg

Keyword(s):

Drug Dosage ◽

Drug Dose ◽

Dosage Forms ◽

Age Group ◽

Vulnerable Patients ◽

Change In Practice ◽

Drug Dosage Form ◽

Child Friendly ◽

One Year ◽

Dosing Accuracy

BackgroundSince there is a lack of drugs in suitable strengths and child-friendly dosage forms, manipulation is sometimes necessary in paediatrics. A manipulation is the physical alteration of a drug dosage form with the purpose to extract and administer the prescribed proportion of a drug dose.The purpose of this study was to calculate the frequency of manipulated medicines administered to paediatric in-patients at a large Children´s Hospital for two separate years and compare whether there has been a change in practice.Material and MethodsData were collected for all administered doses during 2 separate years (2009 and 2018) at the paediatric wards at our Children´s Hospital, from a hospital-based electronic register. All administered doses where the number of tablets or suppositories were decimal were added and calculated as a percentage of the total number of oral and rectal administrations. Data are anonymous but information regarding gender, age, hospital ward and number of drugs per patient were available and were analysed.ResultsIn one year, approximately 450 000 doses of medicine are administered to paediatric patients in our Children´s hospital.The results will be analysed with regards to differences between patient age, gender, prescribing year and drug substance. A pilot study showed that 10% of all solid oral administrations to patients 6 - 12 years old, were part of a tablet. For patients 0 - 2 years over 20% of all solid rectal administrations were part of a suppository.The extent of manipulation is affected by a lot of factors, where the most prominent is whether there are strengths suitable for that age-group available on the market or not.ConclusionMost often there is a lack of knowledge how manipulation of medicines influences the dosing accuracy and often we do this to our most vulnerable patients.Disclosure(s)Nothing to disclose

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