Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning

BackgroundSince there is a lack of drugs in suitable strengths and child-friendly dosage forms, manipulation is sometimes necessary in paediatrics. A manipulation is the physical alteration of a drug dosage form with the purpose to extract and administer the prescribed proportion of a drug dose.The purpose of this study was to calculate the frequency of manipulated medicines administered to paediatric in-patients at a large Children´s Hospital for two separate years and compare whether there has been a change in practice.Material and MethodsData were collected for all administered doses during 2 separate years (2009 and 2018) at the paediatric wards at our Children´s Hospital, from a hospital-based electronic register. All administered doses where the number of tablets or suppositories were decimal were added and calculated as a percentage of the total number of oral and rectal administrations. Data are anonymous but information regarding gender, age, hospital ward and number of drugs per patient were available and were analysed.ResultsIn one year, approximately 450 000 doses of medicine are administered to paediatric patients in our Children´s hospital.The results will be analysed with regards to differences between patient age, gender, prescribing year and drug substance. A pilot study showed that 10% of all solid oral administrations to patients 6 - 12 years old, were part of a tablet. For patients 0 - 2 years over 20% of all solid rectal administrations were part of a suppository.The extent of manipulation is affected by a lot of factors, where the most prominent is whether there are strengths suitable for that age-group available on the market or not.ConclusionMost often there is a lack of knowledge how manipulation of medicines influences the dosing accuracy and often we do this to our most vulnerable patients.Disclosure(s)Nothing to disclose

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French and/or European perspectives on biopharmaceutical characterization of drug dosage forms

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/0731-7085(90)80059-x ◽

1990 ◽

Vol 8 (6) ◽

pp. 499-506 ◽

Cited By ~ 3

Author(s):

J.-M. Aiache

Keyword(s):

Drug Dosage ◽

Dosage Forms

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In vitro dissolution of sparingly water-soluble drug dosage forms

International Journal of Pharmaceutics ◽

10.1016/0378-5173(95)00123-z ◽

1995 ◽

Vol 125 (1) ◽

pp. 99-106 ◽

Cited By ~ 38

Author(s):

Vinod P. Shah ◽

Assad Noory ◽

Carol Noory ◽

Bruce McCullough ◽

Sanford Clarke ◽

...

Keyword(s):

Drug Dosage ◽

Dosage Forms ◽

Water Soluble ◽

In Vitro Dissolution ◽

Water Soluble Drug

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Microscopic methods in analysis of submicron phospholipid dispersions

Acta Pharmaceutica ◽

10.1515/acph-2016-0003 ◽

2016 ◽

Vol 66 (1) ◽

pp. 1-22 ◽

Cited By ~ 13

Author(s):

Marcin Płaczek ◽

Magdalena Kosela

Keyword(s):

Electron Microscopy ◽

Pharmaceutical Formulations ◽

Drug Dosage ◽

Dosage Forms ◽

Drug Formulation ◽

Specific Drug ◽

Pharmaceutical Technology ◽

Microscopic Techniques

Abstract Microscopy belongs to the group of tests, used in pharmaceutical technology, that despite the lapse of time and the development of new analytical methods, still remain irreplaceable for the characterization of dispersed drug dosage forms (e.g., suspensions and emulsions). To obtain complete description of a specific drug formulation, such as parenteral colloidal products, a combination of different microscopic techniques is sometimes required. Electron microscopy methods are the most useful ones; however, even such basic methods as optical microscopy may be helpful for determination of some properties of a sample. The publication explicates the most popular microscopical techniques used nowadays for characterization of the morphology of nanoparticles suspended in pharmaceutical formulations; ad vantages and disadvantages of these methods are also discussed. Parenteral submicron formulations containing lecithin or a particular phospholipid were chosen as examples.

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ANALISIS PELAYANAN INFORMASI OBAT (PIO) PADA PASIEN DI APOTEK X PERIODE MEI 2021

Edu Masda Journal ◽

10.52118/edumasda.v5i2.129 ◽

2021 ◽

Vol 5 (2) ◽

pp. 41

Author(s):

Neneng Sri Purwaningsih ◽

Ahmad Senjaya ◽

Jeniar Ulfita Rukmana

Keyword(s):

Drug Interactions ◽

Drug Information ◽

Information Service ◽

Sampling Technique ◽

Drug Dosage ◽

Dosage Forms ◽

Information Services ◽

Drug Side Effects ◽

Drug Information Services ◽

Drug Doses

Drug Information Service is an activity of providing and providing information, drug recommendations that are independent, accurate, unbiased, current and comprehensive carried out. The purpose of this study was to analyze the description of drug information services received by patients. This research method is descriptive with accidental sampling technique based on a survey with a sample of 62 respondents. The results of the questionnaire given to patients regarding drug information services were obtained regarding the provision of drug information through leaflets or brochures as much as 22.58% were always carried out; information related to drug names as much as 80.65% is always carried out; drug dosage forms (tabelts, capsules, syrups, creams, ointments, etc.) as much as 82.26% are always carried out; drug doses as much as 77.42% are always carried out; how to use drugs as much as 85.48% are always done; the method of storing drugs as much as 80.65% is always carried out; drug indications as much as 72.58% are always carried out; drug interactions as much as 75.81% are always carried out; prevention of drug interactions as much as 74.19% is always done; drug side effects as much as 79.03% are always carried out; the method of destroying drugs (throwing, burning, or burying) 9.68% is always done. It's just that in drug information services regarding the provision of leaflets or brochures the results are 22.58% and the method of destroying drugs is 9.68%, which means that pharmacists rarely provide information and education to patients at the pharmacy about giving leaflets or brochures and how to destroy drugs. ABSTRAKPelayanan Informasi Obat merupakan kegiatan penyediaan dan pemberian informasi, rekomendasi obat yang independen, akurat, tidak bias, terkini dan komprehensif. Tujuan penelitian ini menganalisis mengidentifikasi gambaran pelayanan informasi obat yang di terima oleh pasien di Apotek X. Metode penelitian ini yaitu deskriptif dengan teknik accidental sampling berdasarkan survei dengan sampel yang didapat yaitu 62 responden. Hasil penelitian dari kuisioner yang diberikan pada pasien mengenai pelayanan informasi obat didapatkan mengenai pemberian informasi obat melalui leaflet atau brosur sebanyak 22,58% selalu dilakukan; informasi terkait nama obat sebanyak 80,65% selalu dilakukan; bentuk sediaan obat (tabelt, kapsul, sirup, cream, salep, dll) sebanyak 82,26% selalu dilakukan; dosis obat sebanyak 77,42% selalu dilakukan; cara pemakaian obat sebanyak 85,48% selalu dilakukan; cara penyimpanan obat sebanyak 80,65% selalu dilakukan; indikasi obat sebanyak 72,58% selalu dilakukan; interaksi obat sebanyak 75,81% selalu dilakukan; pencegahan terhadap interaksi obat sebanyak 74,19% selalu dilakukan; efek samping obat sebanyak 79,03% selalu dilakukan; cara pemusnahan obat (dibuang, dibakar, atau dikubur) sebanyak 9,68% selalu dilakukan. Hanya saja pada pelayanan informasi obat mengenai pemberian leaflet atau brosur hasilnya 22,58% dan cara pemusnahan obat hasilnya 9,68% yang artinya masih jarang dilakukannya pemberian informasi dan edukasi oleh Apoteker kepada pasien di Apotek tersebut tentang pemberian leaflet atau brosur dan cara pemusnahan obat.

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