Cutaneous mucormycosis of nose and facial region in children: A case series

Patients with extensive burns are an important group at risk for cutaneous mucormycosis. This study aimed to perform a systematic review of all reported mucormycosis cases in burn patients from 1990 onward. A Medline search yielded identification of 7 case series, 3 outbreaks, and 25 individual cases reports. The prevalence reached 0.04%–0.6%. The median age was 42–48 in the case series and outbreaks, except for the studies from military centers (23.5–32.5) and in individual reports (29.5). The median total body surface area reached 42.5%–65%. Various skin lesions were described, none being pathognomonic: the diagnosis was mainly reached because of extensive necrotic lesions sometimes associated with sepsis. Most patients were treated with systemic amphotericin B or liposomal amphotericin B, and all underwent debridement and/or amputation. Mortality reached 33%–100% in the case series, 29%–62% during outbreaks, and 40% in individual cases. Most patients were diagnosed using histopathology and/or culture. Mucorales qPCR showed detection of circulating DNA 2–24 days before the standard diagnosis. Species included the main clinically relevant mucorales (i.e., Mucor, Rhizopus, Absidia/Lichtheimia, Rhizomucor) but also more uncommon mucorales such as Saksenaea or Apophysomyces. Contact with soil was reported in most individual cases. Bandages were identified as the source of contamination in two nosocomial outbreaks.

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Prenatal diagnosis of cleft lip and cleft lip palate – a case series

Medical Ultrasonography ◽

10.11152/mu-1582 ◽

2018 ◽

Vol 20 (4) ◽

pp. 531 ◽

Cited By ~ 1

Author(s):

Claudiu Marginean ◽

Vladut Sasarean ◽

Cristina Oana Marginean ◽

Lorena Elena Melit ◽

Maria Oana Marginean

Keyword(s):

Prenatal Diagnosis ◽

Cleft Lip ◽

Case Series ◽

3D Ultrasound ◽

Associated Anomalies ◽

Orofacial Clefts ◽

Facial Region ◽

Diagnostic Center ◽

Cleft Lip Palate ◽

The Central Nervous System

Aim: Orofacial clefts comprise cleft lip (CL) or cleft lip-palate (CLP) and are the most frequently encountered malformation of the facial region, accounting for approximately 1-2.2/1,000 live births. The aim of this study was to reveal the particularities regarding the prenatal diagnosis of orofacial clefts in a series of 11 cases diagnosed in a tertiary center.Material and methods: The study was performed in a tertiary diagnostic center for a period of 8 years (January 2010 – December 2017), on8125 patients that were assessed for screening or suspicion of malformations.Results: During the assessed period a number of 11 fetuses (0.13%) were diagnosed by 2D and 3D ultrasound with CL (4 cases) or CLP (7 cases). The smallest gestational age at diagnosis was of 14 weeks, whereas the highest was 35 weeks. Of the 7 cases diagnosed with CLP, 4 presented also other associated anomalies that involved the central nervous system, the kidney, the skeleton and the stomach. All 4 cases of CL had identifiable associated anomalies. Termination of pregnancy was encountered in 3 cases with CLP.Conclusions: CLP can be diagnosed even at the end of the 1st trimester of pregnancy. CL is usually diagnosed during the 2nd trimester ultrasound exam and is commonly an isolated anomaly.

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Systematic Review of the Patterns of Orofacial Injuries in Physically Abused Children and Adolescents

Trauma Violence & Abuse ◽

10.1177/1524838019827617 ◽

2019 ◽

Vol 22 (1) ◽

pp. 136-146 ◽

Cited By ~ 4

Author(s):

Reena Sarkar ◽

Joan Ozanne-Smith ◽

Richard Bassed

Keyword(s):

Children And Adolescents ◽

Physical Abuse ◽

Emotional Abuse ◽

English Language ◽

Case Reports ◽

Grey Literature ◽

Case Series ◽

Child Physical Abuse ◽

The Body ◽

Facial Region

Objective: To examine the evidence base for patterns of oro-facial injuries in physical abuse cases of children and adolescents aged 0-17 years. Data sources: Systematic searches of Ovid Medline, Ovid Embase, Cochrane Central and grey literature, dating from the oldest entry to August 2017. Review methods: Search criteria included English language peer reviewed articles and theses on physical abuse cases affecting the age group of 0-17 years. Exclusion criteria were: Case reports and <10 case series; studies involving bite mark injuries elsewhere on the body, sexual, ritualistic or emotional abuse and neglect, exposure to domestic violence; reviews; book chapters and conference proceedings. The following data was extracted: quality and design of study, oro-facial manifestations, new/old injuries, fatalities, coexistent injuries, co-morbidities and radiologic investigations. Each study was subjected to two independent reviews and a third, if reviewers disagreed. Results: The authors identified 51 articles, 26 of which satisfied the inclusion criteria. The oro-facial signs were superficial injuries of face, ears, neck, lips and oral mucosa, burns, torn fraenii and fractured teeth and jaws. A minority of studies stood out due to their well-developed design; expert opinion inclusion; new/old/occult injury investigations and facial bruising/ intraoral injuries as sentinel markers. Overall, the review demonstrated weak study quality and representativeness as well as lacunae in uniform reporting. Conclusions: The available literature does not endorse any pathognomonic signature patterns of child physical abuse to the exposed oro-facial region.

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