Ear reconstruction research using animal models: The effect of fat grafting on costal cartilage stents

2021 ◽  
pp. 111016
Author(s):  
Xia Chen ◽  
Ruhong Zhang ◽  
Datao Li ◽  
Qun Zhang ◽  
Zhicheng Xu ◽  
...  
Keyword(s):  
Animal Models ◽  
Costal Cartilage ◽  
Fat Grafting ◽  
Ear Reconstruction

scholarly journals Ear Reconstruction Simulation: From Handcrafting to 3D Printing

2019 ◽  
Vol 6 (1) ◽  
pp. 14 ◽  
Author(s):  
Elisa Mussi ◽  
Rocco Furferi ◽  
Yary Volpe ◽  
Flavio Facchini ◽  
Kathleen S. McGreevy ◽  
...  
Keyword(s):  
Costal Cartilage ◽  
Surgical Reconstruction ◽  
Ear Reconstruction ◽  
Autologous Tissue ◽  
Aesthetic Appearance ◽  
History Of ◽  
Common Clinical Practice ◽  
The Aesthetic ◽  
Manufacturing Technologies ◽  
High Level

Microtia is a congenital malformation affecting one in 5000 individuals and is characterized by physical deformity or absence of the outer ear. Nowadays, surgical reconstruction with autologous tissue is the most common clinical practice. The procedure requires a high level of manual and artistic techniques of a surgeon in carving and sculpting of harvested costal cartilage of the patient to recreate an auricular framework to insert within a skin pocket obtained at the malformed ear region. The aesthetic outcomes of the surgery are highly dependent on the experience of the surgeon performing the surgery. For this reason, surgeons need simulators to acquire adequate technical skills out of the surgery room without compromising the aesthetic appearance of the patient. The current paper aims to describe and analyze the different materials and methods adopted during the history of autologous ear reconstruction (AER) simulation to train surgeons by practice on geometrically and mechanically accurate physical replicas. Recent advances in 3D modelling software and manufacturing technologies to increase the effectiveness of AER simulators are particularly described to provide more recent outcomes.

Microtia Repair

2019 ◽  
pp. 461-470
Author(s):  
Melissa Kanack ◽  
Catherine Tsai ◽  
Amanda Gosman
Keyword(s):  
Skin Graft ◽  
Costal Cartilage ◽  
Ear Reconstruction ◽  
External Ear ◽  
Cartilage Graft ◽  
Associated Anomalies ◽  
Ear Canal ◽  
Genetic Syndrome ◽  
Definition Of ◽  
Costal Cartilage Graft

Microtia may occur as an isolated finding or in conjunction with other associated anomalies or a genetic syndrome. Ear reconstruction for these patients is typically performed no earlier than 6 years of age. In this chapter, a staged autogenous method of ear reconstruction is described using costal cartilage. In the first stage, a costal cartilage graft is harvested and placed. The next stages involve lobule transposition, detachment of the auricle with placement of a posterior skin graft, and further refinement of the external ear landmarks with tragus creation and definition of the conchal bowl and ear canal.

scholarly journals Dystrophic Mineralization of Costal Cartilage in Hartley Guinea Pigs

2016 ◽  
Vol 45 (3) ◽  
pp. 435-439
Author(s):  
Alexandria M. Schauer ◽  
Adrienne Schucker ◽  
Cathy S. Carlson
Keyword(s):  
Skeletal Muscle ◽  
Bone Marrow ◽  
Animal Models ◽  
Cross Sections ◽  
Guinea Pigs ◽  
Incidental Findings ◽  
Costal Cartilage ◽  
Osseous Metaplasia ◽  
Animal Models Of Disease ◽  
Models Of Disease

Hartley guinea pigs are widely used animal models of disease, particularly in studies of osteoarthritis. The purpose of this study was to investigate lesions in the costal cartilage from 16 male, 5- to 6-month-old Hartley guinea pigs. Routine histological sections from the costal cartilage and costochondral junction (longitudinal and cross sections) and sternum (for evaluation of bone marrow) were examined. All 16 (100%) animals had histological lesions involving the costal cartilage that included matrix degeneration and mineralization, reduced cellularity, and evidence of chondrocyte necrosis. Of the 16, 4 (25%) of the lesions contained blood vessels and 3 (19%) contained central osseous metaplasia. The cartilage lesions were accompanied by degeneration (sometimes with regeneration and/or fibrosis) in adjacent skeletal muscle in 15 of the 16 (94%) animals. The lesions in the costal cartilage were interpreted as dystrophic mineralization of unknown cause and appear to be incidental findings, although they bear some resemblance to lesions occurring in Tietze’s disease in humans. The significance of the lesions in skeletal muscle is unclear. Histological lesions of cartilage matrix degeneration and mineralization in these sites have not, to our knowledge, been reported previously.

Effect of Platelet-Rich Fibrin on Fat Grafting in Animal Models: A Meta-Analysis

2019 ◽  
Vol 44 (2) ◽  
pp. 570-578 ◽  
Author(s):  
Ruiquan Liu ◽  
Yi Long ◽  
Liu Liu ◽  
Xian Zhao
Keyword(s):  
Animal Models ◽  
Meta Analysis ◽  
Fat Grafting ◽  
Platelet Rich Fibrin

scholarly journals Burned Ear Reconstruction Using a Superficial Temporal Fascia Flap

2020 ◽  
pp. 014556132093762 ◽  
Author(s):  
Peipei Guo ◽  
Haiyue Jiang ◽  
Qinghua Yang ◽  
Leren He ◽  
Lin Lin ◽  
...  
Keyword(s):  
Costal Cartilage ◽  
Good Choice ◽  
Ear Reconstruction ◽  
External Ear ◽  
Temporal Fascia ◽  
Therapeutic Regime ◽  
Fascial Flap ◽  
Temporal Fascial Flap ◽  
Fascia Flap ◽  
Superficial Temporal Fascia

Objectives: Ear deformity caused by burns is one of the most difficult types of deformity to treat with plastic surgery, and the reconstruction of burned ears undoubtedly remains a substantial challenge. This study aims to report the therapeutic regime of using a superficial temporal fascial flap to cover the framework in burned ear reconstruction. Methods: Autologous costal cartilage was used to form the ear framework in all of the reconstruction cases. A superficial temporal fascial flap was used as soft tissue to cover the ear scaffold. Results: Five patients with 6 ears were included in our study. The external ear healed well and the location, size, and shape of both ears were generally symmetrical. No complication was observed in any of the patients. Conclusions: The superficial temporal fascial flap is a good choice for covering the autogenous cartilage framework when treating ear deformities after burns.

scholarly journals Ear Reconstruction Using Autologus Costal Cartilage: A Steep Learning Curve

2018 ◽  
Vol 18 (3) ◽  
pp. 371-377 ◽  
Author(s):  
Paritkumar S. Ladani ◽  
Rajesh Valand ◽  
Hermann Sailer
Keyword(s):  
Learning Curve ◽  
Costal Cartilage ◽  
Ear Reconstruction ◽  
Steep Learning Curve

Autologous Fat Grafting for Oncologic Patients: A Literature Review

2021 ◽  
Vol 41 (Supplement_1) ◽  
pp. S61-S68
Author(s):  
Allison J Seitz ◽  
Malke Asaad ◽  
Summer E Hanson ◽  
Charles E Butler ◽  
Rene D Largo
Keyword(s):  
Stem Cells ◽  
Animal Models ◽  
Cancer Patients ◽  
Tissue Regeneration ◽  
Fat Grafting ◽  
Autologous Fat Grafting ◽  
Reconstructive Procedures ◽  
Autologous Fat ◽  
Increased Risk ◽  
Oncologic Patients

Abstract Autologous fat grafting (AFG) serves as an effective method to address volume defects, contour irregularities, and asymmetry in both aesthetic and reconstructive procedures. In recent years, there has been growing concern about the potential of cancer recurrence and interference with cancer surveillance in oncologic patients receiving AFG. The adipose tissue contains adipose-derived stem cells (ASCs), a specific type of mesenchymal stem cells, that facilitate secretion of numerous growth factors which in turn stimulate tissue regeneration and angiogenesis. As such, it has been theorized that ASCs may also have the potential to stimulate cancer cell proliferation and growth when used in oncologic patients. Multiple research studies have demonstrated the ability of ACSs to facilitate tumor proliferation in animal models. However, clinical research in oncologic patients has yielded contradictory findings. Although the literature pertaining to oncologic safety in head and neck, as well as sarcoma, cancer patients remains limited, studies demonstrate no increased risk of tumor recurrence in these patient populations receiving AFG. Similarly, both the efficacy and safety of AFG have been well established in breast cancer patients through numerous clinical studies. More recently, preclinical research in animal models has shown that AFG has the potential to facilitate tissue regeneration and improve joint contracture following irradiation. Ultimately, further research is needed to elucidate the safety of AFG in a variety of oncologic patients, as well as explore its use in tissue regeneration, particularly in the setting of radiotherapy. Level of Evidence: 4

scholarly journals The Correction of The Auricle in Neurofibroma with Aggressive Tumor Removal Principle and Two Stages Total Ear Reconstruction

1970 ◽  
Vol 1 (3) ◽  
Author(s):  
Kristaninta Bangun ◽  
Zung Chung Chen
Keyword(s):  
Satisfactory Result ◽  
Costal Cartilage ◽  
Radical Resection ◽  
Benign Tumors ◽  
Anatomical Site ◽  
Ear Reconstruction ◽  
Tumor Removal ◽  
Two Stage ◽  
Large Tumor ◽  
Aggressive Tumor

Background: Neurofibroma is a major facial hamartoma and is one of the most destructive and debilitating disease affecting the skin, muscle, mucosa, and the skeletal systems. Involvement of the ear usually increases the dimensions of the auricular skin and underlying tissues, distorts normal architecture along with auricular malpositioning, producing an ear that is abnormal in size, shape and position. The correction of the auricle in neurofibroma and benign tumors of the head and neck has been reported, but overall favorable results appear difficult to attain. We present a case of neurofibroma of the auricle in which radical resection was performed, and reconstruction was done in a two-stage surgery with satisfactory result. Patient and Methods: A 30 years-old female presented with type-1 neurofibroma to our office, especially concerned of a large tumor growth on the right auricle. With prior experience in treating microtia cases by Nagata’s method, we performed a two-stage operation on the patient. The first operation involved excising the whole auricular mass, and fabricating as well as grafting of a three-dimensional costal cartilage framework. In the second stage, the ear was elevated.Result: Nine months after the second surgery, the result was satisfactory with good auricular definition attained, and proper elevation of the ear at the correct anatomical site. No sign of neurofibroma recurrence was found on the surrounding reconstructed auricle.Summary: In our experience, the correction Neurofibroma of the ear by using the aggressive tumor removal principle combined with Nagata’s two-stage total ear reconstruction delivered a satisfactory result.

scholarly journals Microtia reconstruction: our experiences of first 10 cases in Bangladesh

1970 ◽  
Vol 1 (2) ◽  
pp. 14-19
Author(s):  
MS Khondoker ◽  
R Awwal ◽  
MM Sarker ◽  
SH Khundkar
Keyword(s):  
Plastic Surgery ◽  
Costal Cartilage ◽  
Three Dimensional ◽  
Ear Reconstruction ◽  
Two Stage ◽  
College Hospital ◽  
Auricular Reconstruction ◽  
Medical College ◽  
Second Stage ◽  
One Year

Varying degrees of congenital ear deformity (microtia) occurs 1 in about 8000 to 10,000 live births. One of the greatest challenges in plastic surgery is total auricular reconstruction as it demands precise technique as well as artistic creativity. In Bangladesh, recent advancement in the technique of carving and sculpting rib cartilage  and better training for achieving finer anatomic details has given a break through in the surgical management of  deformed ear. Between January 2009 and January 2010, total ear reconstruction was done with a two-stage method using  autogenous costal cartilage in the Department of Plastic Surgery, Dhaka Medical College Hospital, Dhaka. In the first stage, lobule rotation, fabrication of the cartilage framework and its implantation were performed. In  the second stage, elevation of the auricle and formation of the tragus were done. A total of 10 cases with microtia comprising different age group have been operated. All of them underwent stage I operation; among them 8 patients went through stage II procedure while the other 2 are waiting for the same. Results: 10 patients, ranging in age between 8 and 25 years, were operated on using autogenous costal cartilage between 2009 and 2010. Six patients were males and four were females. Unilateral microtia was present in all of these patients (7 right, 3 left). Eight cases were with Grade III microtia; the remaining 2 cases presented with Grade II microtia. The follow-up period was one month to one year. Seven among 8 cases presented acceptable ear contour after second stage ear reconstruction. The cranioauricular angle of the reconstructed ears was also similar to that of the opposite ears. Unfavourable result was deformation of the constructed helix which occurred in one case. Though it is impossible to reconstruct an ear that appears exactly as the opposite one, the new ears which were  made were of correct size and in normal position with impressive finer three dimensional details that achieved patient’s satisfaction as well as surgeon’s professional gratification.Key words: Microtia; Two stage auricular reconstruction; Autologous costochondral cartilageBDJPS 2010; 1(2): 14-19

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