scholarly journals Genomic analysis of the first cases of extensively drug-resistant, travel-related Salmonella enterica serovar Typhi in Oman

IJID Regions ◽  
2021 ◽  
Author(s):  
Azza Al-Rashdi ◽  
Rajesh Kumar ◽  
Mohamed Al-Bulushi ◽  
Seif Al Abri ◽  
Amina Al-Jardani
Keyword(s):  
Salmonella Enterica ◽  
Genomic Analysis ◽  
Drug Resistant ◽  
Salmonella Enterica Serovar Typhi ◽  
Extensively Drug Resistant

scholarly journals Extensively Drug Resistant Salmonella Enterica Serovar Typhi Misdiagnosis In Pakistan: A Matter Of Serious Concern

2021 ◽  
Vol 03 (09) ◽  
pp. 25-27
Author(s):  
Umar Saeed ◽  
◽  
Sara Rizwan Uppal ◽  
Zahra Zahid Piracha ◽  
Rizwan Uppal ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Urban Areas ◽  
Implementation Strategies ◽  
Drug Resistant ◽  
Igg Antibodies ◽  
Salmonella Enterica Serovar Typhi ◽  
Rural And Urban Areas ◽  
Extensively Drug Resistant ◽  
Health Authorities ◽  
Rural And Urban

There have been several outbreaks of antimicrobial resistant (AMR) strains of Salmonella enterica serovar Typhi that cause extensively drug resistant (XDR) typhoid fever in Pakistan. It has been observed that many clinicians use serological diagnostic tests such as Widal agglutination, and TyphiDOT that detects IgM and IgG antibodies against the outer membrane protein of S. Typhi. However, it has been confirmed by many scientists that these test may lead to misdiagnosis against XDR S. Typhi. Due to lack of implementation strategies health authorities are unable to hamper Widal or TyphiDOT tests which are still practiced in many rural and urban areas.

scholarly journals Draft Genome Sequence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi Strain from a Returned Traveler from Pakistan

2020 ◽  
Vol 9 (31) ◽  
Author(s):  
Samantha Hao ◽  
Tess Veuthey ◽  
Saharai Caldera ◽  
Paula Hayakawa Serpa ◽  
Barbara Haller ◽  
...  
Keyword(s):  
Genome Sequencing ◽  
Genome Sequence ◽  
Salmonella Enterica ◽  
Draft Genome ◽  
Draft Genome Sequence ◽  
Whole Genome ◽  
Drug Resistant ◽  
Content Type ◽  
Salmonella Enterica Serovar Typhi ◽  
Extensively Drug Resistant

ABSTRACT We report a draft genome sequence of extensively drug-resistant (XDR) Salmonella enterica serotype Typhi isolated from a returned traveler from Pakistan who developed sepsis. Whole-genome sequencing revealed relatedness to a previously reported outbreak in Pakistan and identified the blaCTX-M-15 and qnrS resistance genes.

scholarly journals Importation of Extensively Drug-Resistant Salmonella enterica Serovar Typhi Cases in Ontario, Canada

2020 ◽  
Vol 64 (5) ◽  
Author(s):  
Alireza Eshaghi ◽  
Sandra Zittermann ◽  
Amrita Bharat ◽  
Michael R. Mulvey ◽  
Vanessa G. Allen ◽  
...  
Keyword(s):  
Genome Sequencing ◽  
Salmonella Enterica ◽  
Bloodstream Infections ◽  
Whole Genome ◽  
Drug Resistant ◽  
Outbreak Strain ◽  
Travel History ◽  
Content Type ◽  
Salmonella Enterica Serovar Typhi ◽  
Extensively Drug Resistant

ABSTRACT A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections (n = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were genetically related to the Pakistan outbreak strain. The appearance of XDR typhoid cases in Ontario prompted a provincial wide alert to physicians to recommend treatment with carbapenems or azithromycin in suspected typhoid cases with travel history to Pakistan.

scholarly journals First Case of Typhoid Fever due to Extensively Drug-resistant Salmonella enterica serovar Typhi in Italy

Pathogens ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 151 ◽  
Author(s):  
Michela Procaccianti ◽  
Alice Motta ◽  
Stefano Giordani ◽  
Sara Riscassi ◽  
Battista Guidi ◽  
...  
Keyword(s):  
Typhoid Fever ◽  
Salmonella Enterica ◽  
Empiric Therapy ◽  
Fluoroquinolone Resistance ◽  
Drug Resistant ◽  
Salmonella Enterica Serovar Typhi ◽  
Extensively Drug Resistant ◽  
First Case ◽  
Life Threatening ◽  
Additional Resistance

Typhoid fever is a potentially severe and occasionally life-threatening bacteraemic illness caused by Salmonella enterica serovar Typhi (S. Typhi). In Pakistan, an outbreak of extensively drug-resistant (XDR) S. Typhi cases began in November 2016. We report on a five-year-old boy who contracted enteric fever while travelling in Pakistan and was diagnosed after returning to Italy in September 2019. Blood culture isolated Salmonella enterica serovar Typhi that was XDR to all first-line antibiotics, including ceftriaxone and fluoroquinolones. Empiric therapy was switched to meropenem, and the patient recovered completely. Whole-genome sequencing showed that this isolate was of haplotype H58. The XDR S. Typhi clone encoded a chromosomally located resistance region and harbored a plasmid encoding additional resistance elements, including the blaCTX-M-15 extended-spectrum β-lactamase and the qnrS fluoroquinolone resistance gene. This is the first case of typhoid fever due to XDR S. Typhi detected in Italy and one of the first paediatric cases reported outside Pakistan, highlighting the need to be vigilant for future cases. While new vaccines against typhoid are in development, clinicians should consider adapting their empiric approach for patients returning from regions at risk of XDR S. Typhi outbreak with typhoid symptoms.

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