Retrospective Analysis of the Impact of HPV Status and Smoking on Mucositis in Patients With Oropharyngeal Squamous Cell Carcinoma Treated With Concurrent Chemotherapy and Radiation Therapy

Since there is no published randomized study comparing surgical and non-surgical therapeutic strategies in patients with oropharyngeal squamous cell carcinoma (OPSCC), the therapeutic management of these patients remains highly controversial. While human papillomavirus (HPV)-positive and HPV-negative OPSCC are now recognized as two distinct diseases with different epidemiological, biological, and clinical characteristics, the impact of HPV status on the management of OPSCC patients is still unclear. In this review, we analyze the current therapeutic options in patients with OPSCC, highlighting the most recent advances in surgical and non-surgical therapies, and we discuss the impact of HPV status on the therapeutic strategy.

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Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma

Head & Neck ◽

10.1002/hed.21657 ◽

2011 ◽

Vol 33 (12) ◽

pp. 1727-1734 ◽

Cited By ~ 22

Author(s):

Simon R. Best ◽

Patrick K. Ha ◽

Ray G. Blanco ◽

John R. Saunders ◽

Eva S. Zinreich ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Radiation Therapy ◽

Cell Carcinoma ◽

Squamous Cell ◽

Concurrent Chemotherapy ◽

Oropharyngeal Squamous Cell Carcinoma ◽

Factors Associated

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Evaluation of the impact of tumor HPV status on outcome in patients with locally advanced unresectable head and neck squamous cell carcinoma (HNSCC) receiving cisplatin, 5-Fluorouracil with or without docetaxel: retrospective analysis of EORTC24971 study.

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.15_suppl.6061 ◽

2015 ◽

Vol 33 (15_suppl) ◽

pp. 6061-6061

Author(s):

Amanda Psyrri ◽

Catherine Fortpied ◽

George Koutsodontis ◽

Margaritis Avgeris ◽

Jessica Menis ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Retrospective Analysis ◽

Squamous Cell ◽

Locally Advanced ◽

Neck Squamous Cell Carcinoma ◽

Hpv Status ◽

The Impact

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Transitions in oral and gut microbiome of HPV+ oropharyngeal squamous cell carcinoma following definitive chemoradiotherapy (ROMA LA-OPSCC study)

British Journal of Cancer ◽

10.1038/s41416-020-01253-1 ◽

2021 ◽

Author(s):

Marc Oliva ◽

Pierre H. H. Schneeberger ◽

Victor Rey ◽

Matthew Cho ◽

Rachel Taylor ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Taxonomic Composition ◽

Oropharyngeal Squamous Cell Carcinoma ◽

Oral Microbiome ◽

Metagenomic Sequencing ◽

Α Diversity ◽

16S Rna ◽

The Impact

Abstract Background Oral and gut microbiomes have emerged as potential biomarkers in cancer. We characterised the oral and gut microbiomes in a prospective observational cohort of HPV+ oropharyngeal squamous cell carcinoma (OPSCC) patients and evaluated the impact of chemoradiotherapy (CRT). Methods Saliva, oropharyngeal swabs over the tumour site and stool were collected at baseline and post-CRT. 16S RNA and shotgun metagenomic sequencing were used to generate taxonomic profiles, including relative abundance (RA), bacterial density, α-diversity and β-diversity. Results A total of 132 samples from 22 patients were analysed. Baseline saliva and swabs had similar taxonomic composition (R2 = 0.006; p = 0.827). Oropharyngeal swabs and stool taxonomic composition varied significantly by stage, with increased oral RA of Fusobacterium nucleatum observed in stage III disease (p < 0.05). CRT significantly reduced the species richness and increased the RA of gut-associated taxa in oropharyngeal swabs (p < 0.05), while it had no effect in stool samples. These findings remained significant when adjusted by stage, smoking status and antibiotic use. Conclusions Baseline oral and gut microbiomes differ by stage in this HPV+ cohort. CRT caused a shift towards a gut-like microbiome composition in oropharyngeal swabs. Stage-specific features and the transitions in oral microbiome might have prognostic and therapeutic implications.

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