Theoretical evaluation of bio-thermal response in human tissue subjected to pulse-laser induced hyperthermia therapy for cancer treatment

2022 ◽  
Vol 172 ◽  
pp. 107346
Author(s):  
Jaideep Dutta ◽  
Balaram Kundu
Keyword(s):  
Cancer Treatment ◽  
Pulse Laser ◽  
Human Tissue ◽  
Thermal Response ◽  
Theoretical Evaluation ◽  
Induced Hyperthermia ◽  
Hyperthermia Therapy

Two-dimensional hybrid analytical approach for the investigation of thermal aspects in human tissue undergoing regional hyperthermia therapy

2020 ◽  
Vol 234 (20) ◽  
pp. 3951-3966
Author(s):  
Jaideep Dutta ◽  
Balaram Kundu
Keyword(s):  
Heat Flux ◽  
Heat Conduction ◽  
Cancer Treatment ◽  
Thermal Response ◽  
Skin Tissue ◽  
Hyperbolic Heat Conduction ◽  
Two Dimensional ◽  
Regional Hyperthermia ◽  
Hyperthermia Therapy ◽  
The Impact

The formation of the present work is based on the development of the exact analytical solution of two-dimensional temperature response by employing the hyperbolic heat conduction bioheat model in a single-layered human skin tissue subjected to the regional hyperthermia therapy (RHT) for cancer treatment. The mathematical approach has been utilized as a hybrid form of ‘separation of variables’ and ‘finite integral transform’ method. Three kinds of surface heat fluxes (constant, sinusoidal and cosine) have been employed as an external heat source on the therapeutic surface of the square-shaped skin tissue of 100 mm × 100 mm. An innovative form of initial condition (spatially dependent) has been implemented in the present mathematical formulation as skin tissues are highly non-homogeneous and non-uniform in structure. The present research outcome indicates that cosine heat flux would be a suitable alternative for the sinusoidal heat flux. The impact of the relaxation time lag has been clearly noted in the thermal response with the waveform-like behaviour and it justifies the postulate of hyperbolic heat conduction. The two-dimensional temperature of the skin tissue has been observed in the range of 48.1 ℃–40 ℃ (in decreasing order). Estimated peak temperatures are in the proposed spectrum of hyperthermia therapy for an exposure time of 100 s, and this fact is true in an agreement with the medical protocol of the cancer treatment. The accuracy of the mathematical modelling and in-house computer codes are justified with the published numerical models and the maximum deviation of the thermal response has been noticed in order of 1.5–3%. The two-dimensional surface thermal contours have provided a glimpse of heat flow in the physical domain of skin tissue under different heating conditions and this research output may be beneficial to establish the theoretical standard of the regional hyperthermia treatment for cancer eradication.

scholarly journals Nanoparticles in enhancing microwave imaging and microwave Hyperthermia effect for liver cancer treatment

2021 ◽  
Vol 60 (1) ◽  
pp. 223-236
Author(s):  
Walaa Maamoun ◽  
Mohamed I. Badawi ◽  
Ayman A Aly ◽  
Y. Khedr
Keyword(s):  
Silver Nanoparticles ◽  
Liver Cancer ◽  
Cancer Treatment ◽  
Electromagnetic Waves ◽  
Microwave Imaging ◽  
Healthy Tissue ◽  
Cancer Tissue ◽  
Hyperthermia Treatment ◽  
Hyperthermia Therapy ◽  
Surrounding Healthy Tissue

Abstract Hyperthermia therapy is a promising therapy for liver cancer treatment that utilizes external electromagnetic waves to heat the tumor zone to preferentially kill or minimize cancer cells. Nevertheless, it’s a challenge to realize localized heating of the cancer tissue without harming the surrounding healthy tissue. This research proposes to utilize nanoparticles as microwave absorbers to enhance microwave imaging and achieve localized hyperthermia therapy. A realistic 3D abdomen model has been segmented using 3D Slicer segmentation software, and then the obtained segmented CAD model exported to Computer Simulation Technology (CST STUDIO) for applying the Finite Element Modeling (FEM). Next investigating both imaging and treatment capability. Finally, the specific absorption rate (SAR) and temperature distribution were computed without nanoparticles and with different types of nanoparticles such as gold (GNPs) and silver nanoparticles at frequency 915 MHz. By comparing the achived results, it was seen that Silver nanoparticles can make a great enhancement in raising the temperature. However, this result was unsatisfactory but, after adding gold nanoparticles the temperature exceed 42°C, at frequency 915 MHz which is achieving the hyperthermia treatment without harming the nearby healthy tissue, GNPs also can achieve a great enhancement in SAR result

Microwave-induced hyperthermia in cancer treatment: Apparatus and preliminary results

1978 ◽  
Vol 4 (11-12) ◽  
pp. 1095-1103 ◽  
Author(s):  
Jozef Mendecki ◽  
Esther Friedenthal ◽  
Charles Botstein ◽  
Fred Sterzer ◽  
Robert Paglione ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Preliminary Results ◽  
Induced Hyperthermia

scholarly journals Nanoparticles-based magnetic and photo induced hyperthermia for cancer treatment

Nano Today ◽  
2019 ◽  
Vol 29 ◽  
pp. 100795 ◽  
Author(s):  
S.K. Sharma ◽  
Navadeep Shrivastava ◽  
Francesco Rossi ◽  
Le Duc Tung ◽  
Nguyen Thi Kim Thanh
Keyword(s):  
Cancer Treatment ◽  
Induced Hyperthermia

Localized cancer treatment by radio-frequency hyperthermia using magnetic nanoparticles immobilized on graphene oxide: from novel synthesis to in vitro studies

2018 ◽  
Vol 6 (33) ◽  
pp. 5385-5399 ◽  
Author(s):  
Ravi Kumar ◽  
Anjali Chauhan ◽  
Sushil K. Jha ◽  
Bijoy Kumar Kuanr
Keyword(s):  
Graphene Oxide ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Radio Frequency ◽  
Cancer Treatment ◽  
In Vitro Studies ◽  
Hybrid Nanocomposite ◽  
Novel Synthesis ◽  
Hyperthermia Therapy

Innovative, theranostic hybrid nanocomposite of graphene oxide and iron oxide for radio-frequency hyperthermia therapy.

scholarly journals Magnetic nanofibers based bandage for skin cancer treatment: a non‐invasive hyperthermia therapy

2020 ◽  
Vol 3 (6) ◽  
Author(s):  
Kaushik Suneet ◽  
Tamasa De ◽  
Annapoorni Rangarajan ◽  
Shilpee Jain
Keyword(s):  
Skin Cancer ◽  
Cancer Treatment ◽  
Non Invasive ◽  
Hyperthermia Therapy ◽  
Magnetic Nanofibers

Laser-induced thermal response and characterization of nanoparticles for cancer treatment using magnetic resonance thermal imaging

2007 ◽  
Vol 34 (7) ◽  
pp. 3102-3108 ◽  
Author(s):  
Andrew M. Elliott ◽  
R. Jason Stafford ◽  
Jon Schwartz ◽  
James Wang ◽  
Anil M. Shetty ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Cancer Treatment ◽  
Thermal Imaging ◽  
Thermal Response

scholarly journals Temperature control during nanoparticle-sensitized hyperthermia

2021 ◽  
Vol 2058 (1) ◽  
pp. 012025
Author(s):  
Egor A. Bobkov ◽  
Angelina V. Kosheleva ◽  
Alexander Yu. Kharin ◽  
Victor Yu. Timoshenko
Keyword(s):  
Cancer Treatment ◽  
Temperature Control ◽  
External Stimulus ◽  
Treatment Approaches ◽  
Local Hyperthermia ◽  
Induced Hyperthermia ◽  
Non Invasive ◽  
Silicon Based

Abstract Hyperthermia is one of the mild cancer treatment approaches, which can be realized via a non-invasive way. It has been established that nanoparticles are effective for local hyperthermia enhancement when stimulated by an external stimulus. We show that silicon-based nanoparticles can be used as sensitizers for radiofrequency-induced hyperthermia and propose a thermographic method to control the temperature during the treatment.

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