scholarly journals Significance of senescence for virus-specific memory T cell responses: rapid ageing during chronic stimulation of the immune system

2005 ◽  
Vol 97 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Debbie van Baarle ◽  
Aster Tsegaye ◽  
Frank Miedema ◽  
Arne Akbar
Keyword(s):  
Immune System ◽  
T Cell ◽  
T Cell Responses ◽  
Chronic Stimulation ◽  
Memory T Cell ◽  
Cell Responses ◽  
Specific Memory ◽  
Stimulation Of

scholarly journals Detection of IFNγ-Secreting CD4+ and CD8+ Memory T Cells in COVID-19 Convalescents after Stimulation of Peripheral Blood Mononuclear Cells with Live SARS-CoV-2

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1490
Author(s):  
Victoria Matyushenko ◽  
Irina Isakova-Sivak ◽  
Igor Kudryavtsev ◽  
Arina Goshina ◽  
Anna Chistyakova ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Memory T Cells ◽  
Natural Infection ◽  
Intracellular Cytokine Staining ◽  
T Cell Responses ◽  
Effector Memory ◽  
Memory T Cell ◽  
Cell Responses ◽  
Stimulation Of

Background: New coronavirus SARS-CoV-2, a causative agent of the COVID-19 pandemic, has been circulating among humans since November 2019. Multiple studies have assessed the qualitative and quantitative characteristics of virus-specific immunity in COVID-19 convalescents, however, some aspects of the development of memory T-cell responses after natural SARS-CoV-2 infection remain uncovered. Methods: In most of published studies T-cell immunity to the new coronavirus is assessed using peptides corresponding to SARS-CoV-1 or SARS-CoV-2 T-cell epitopes, or with peptide pools covering various parts of the viral proteins. Here, we determined the level of CD4+ and CD8+ memory T-cell responses in COVID-19 convalescents by stimulating PBMCs collected 1 to 6 months after recovery with sucrose gradient-purified live SARS-CoV-2. IFNγ production by the central and effector memory helper and cytotoxic T cells was assessed by intracellular cytokine staining assay and flow cytometry. Results: Stimulation of PBMCs with live SARS-CoV-2 revealed IFNγ-producing T-helper effector memory cells with CD4+CD45RA−CCR7− phenotype, which persisted in circulation for up to 6 month after COVID-19. In contrast, SARS-CoV-2-specific IFNγ-secreting cytotoxic effector memory T cells were found at significant levels only shortly after the disease, but rapidly decreased over time. Conclusion: The stimulation of immune cells with live SARS-CoV-2 revealed a rapid decline in the pool of effector memory CD8+, but not CD4+, T cells after recovery from COVID-19. These data provide additional information on the development and persistence of cellular immune responses after natural infection, and can inform further development of T cell-based SARS-CoV-2 vaccines.

scholarly journals IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Lyssia Belarif ◽  
Caroline Mary ◽  
Lola Jacquemont ◽  
Hoa Le Mai ◽  
Richard Danger ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Inflammation ◽  
T Cell Responses ◽  
Receptor Blockade ◽  
Memory T Cell ◽  
Cell Responses ◽  
Specific Memory

scholarly journals Norovirus-Specific Memory T Cell Responses in Adult Human Donors

2016 ◽  
Vol 7 ◽  
Author(s):  
Maria Malm ◽  
Kirsi Tamminen ◽  
Timo Vesikari ◽  
Vesna Blazevic
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Memory T Cell ◽  
Cell Responses ◽  
Adult Human ◽  
Specific Memory

scholarly journals Antibody Avidity in Humoral Immune Responses in Bangladeshi Children and Adults following Administration of an Oral Killed Cholera Vaccine

2013 ◽  
Vol 20 (10) ◽  
pp. 1541-1548 ◽  
Author(s):  
Mohammad Murshid Alam ◽  
Daniel T. Leung ◽  
Marjahan Akhtar ◽  
Mohammad Nazim ◽  
Sarmin Akter ◽  
...  
Keyword(s):  
T Cell ◽  
B Cell ◽  
T Cell Responses ◽  
Memory B Cell ◽  
Antibody Avidity ◽  
Memory T Cell ◽  
Cell Responses ◽  
Specific Memory ◽  
Iga Antibodies ◽  
Specific Igg

ABSTRACTAntibody avidity for antigens following disease or vaccination increases with affinity maturation and somatic hypermutation. In this study, we followed children and adults in Bangladesh for 1 year following oral cholera vaccination and measured the avidity of antibodies to the T cell-dependent antigen cholera toxin B subunit (CTB) and the T cell-independent antigen lipopolysaccharide (LPS) in comparison with responses in other immunological measurements. Children produced CTB-specific IgG and IgA antibodies of high avidity following vaccination, which persisted for several months; the magnitudes of responses were comparable to those seen in adult vaccinees. The avidity of LPS-specific IgG and IgA antibodies in vaccinees increased significantly shortly after the second dose of vaccine but waned rapidly to baseline levels thereafter. CTB-specific memory B cells were present for only a short time following vaccination, and we did not find significant memory B cell responses to LPS in any age group. For older children, there was a significant correlation between CTB-specific memory T cell responses after the second dose of vaccine and CTB-specific IgG antibody avidity indices over the subsequent year. These findings suggest that vaccination induces a longer-lasting increase in the avidity of antibodies to a T cell-dependent antigen than is measured by a memory B cell response to that antigen and that early memory T cell responses correlate well with the subsequent development of higher-avidity antibodies.

Belatacept Can Inhibit Allo-Specific T Cell Responses in a Donor-Dependent Manner But Preserves Virus-Specific Memory T Cell-Responses.

2014 ◽  
Vol 98 ◽  
pp. 36
Author(s):  
C. Falk ◽  
K. Daemen ◽  
M. Stevanovic-Meyer ◽  
F. Lehner ◽  
H. Haller ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Dependent Manner ◽  
Memory T Cell ◽  
Cell Responses ◽  
Specific Memory

scholarly journals Persistent Cellular Immunity to SARS-CoV-2 Infection

2020 ◽  
Author(s):  
Gaëlle Breton ◽  
Pilar Mendoza ◽  
Thomas Hagglof ◽  
Thiago Y. Oliveira ◽  
Dennis Schaefer-Babajew ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Cell Division ◽  
T Cell ◽  
T Cell Responses ◽  
Memory T Cell ◽  
Cell Responses ◽  
Paired Samples ◽  
Specific Memory ◽  
Immune Alterations

AbstractSARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4+ and CD8+ T cells, expression of activation/exhaustion markers, and cell division.SummaryWe show that SARS-CoV-2 infection elicits broadly reactive and highly functional memory T cell responses that persist 6 months after infection. In addition, recovered individuals show enduring immune alterations in CD4+ and CD8+ T cells compartments.

Induction of HIV-specific memory T-cell responses by topical DermaVir vaccine

Vaccine ◽  
2007 ◽  
Vol 25 (16) ◽  
pp. 3070-3074 ◽  
Author(s):  
Sandra A. Calarota ◽  
David B. Weiner ◽  
Franco Lori ◽  
Julianna Lisziewicz
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Memory T Cell ◽  
Cell Responses ◽  
Specific Memory

scholarly journals Thyrotrophin receptor-specific memory T cell responses require normal B cells in a murine model of Graves’ disease

2003 ◽  
Vol 134 (3) ◽  
pp. 396-402 ◽  
Author(s):  
P. PICHURIN ◽  
H. ALIESKY ◽  
C-R. CHEN ◽  
Y. NAGAYAMA ◽  
B. RAPOPORT ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Murine Model ◽  
T Cell Responses ◽  
Graves Disease ◽  
Memory T Cell ◽  
Cell Responses ◽  
Specific Memory
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