Baseline cerebral oximetry values in elderly patients with hip fractures: A prospective observational study

Aim: This study was conducted to examine perioperative cerebral oximetry changes in elderly patients undergoing hip fracture repair and evaluate the correlation between regional oxygen saturation (rSO2) values, postoperative cognitive dysfunction (POCD) and hospital stay. Materials and Methods: This prospective observational study included 69 patients. Data recorded included demographic information, rSO2 values from baseline until the second postoperative hour and Mini Mental State Examination (MMSE) scores preoperatively and on postoperative day 7. MMSE score ≤23 was considered evidence of cognitive dysfunction. Postoperative confusion or agitation, medications administered for postoperative agitation, and hospital length of stay were also recorded. Data were analyzed with Student’s t-test, Pearson’s correlation or multiple regression analysis as appropriate. Results: Patient age was 74±13 years. Baseline left sided rSO2 values were 60±10 and increased significantly after intubation. Baseline rSO2 L<50 and <45 was observed in 11.6% and 10.1% of patients respectively. Perioperative cerebral desaturation occurred in 40% of patients. MMSE score was 26.23 ± 2.77 before surgery and 25.94 ± 2.52 on postoperative day 7 (p=0.326). MMSE scores ≤ 23 were observed preoperatively in 6 and postoperatively in 9 patients. Patients with cognitive dysfunction had lower preoperative hematocrit, hemoglobin, SpO2 and rSO2 values at all times, compared to patients who did not. There was no correlation between rSO2 or POCD and hospital stay. Patients with baseline rSO2 <5 required more medications for postoperative agitation. Conclusion: Cognitive dysfunction occurs preoperatively and postoperatively in elderly patients with hip fractures, and is associated with low cerebral rSO2 values.

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Cerebral oximetry during preoperative resuscitation in elderly patients with hip fracture: a prospective observational study

Journal of Clinical Monitoring and Computing ◽

10.1007/s10877-018-0107-6 ◽

2018 ◽

Vol 32 (6) ◽

pp. 1033-1040 ◽

Cited By ~ 5

Author(s):

C. G. Clemmesen ◽

L. M. Pedersen ◽

S. Hougaard ◽

M. L. Andersson ◽

V. Rosenkvist ◽

...

Keyword(s):

Hip Fracture ◽

Observational Study ◽

Elderly Patients ◽

Prospective Observational Study ◽

Cerebral Oximetry

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Safety of High-Dose Dabigatran in Elderly and Younger Patients with a Low Bleeding Risk: A Prospective Observational Study

Cardiology ◽

10.1159/000516368 ◽

2021 ◽

pp. 1-5

Author(s):

Aharon Erez ◽

Gregory Golovchiner ◽

Robert Klempfner ◽

Ehud Kadmon ◽

Gustavo Ruben Goldenberg ◽

...

Keyword(s):

Observational Study ◽

Elderly Patients ◽

Prospective Observational Study ◽

Bleeding Risk ◽

The Elderly ◽

High Dose ◽

World Population ◽

Younger Patients ◽

End Point

Introduction: In patients with atrial fibrillation (AF) at risk for stroke, dabigatran 150 mg twice a day (DE150) is superior to warfarin for stroke prevention. However, there is paucity of data with respect to bleeding risk at this dose in elderly patients (≥75 years). We aimed to evaluate the safety of DE150 in comparison to warfarin in a real-world population with AF and low bleeding risk (HAS-BLED score ≤2). Methods: In this prospective observational study, 754 consecutive patients with AF and HAS-BLED score ≤2 were included. We compared outcome of elderly patients (age ≥75 tears) to younger patients (age <75 years). The primary end point was the combined incidence of all-cause mortality, stroke, systemic emboli, and major bleeding event during a mean follow-up of 1 year. Results: There were 230 (30%) elderly patients, 151 patients were treated with warfarin, and 79 were treated with DE150. Fifty-two patients experienced the primary endpoint during the 1-year follow-up. Among the elderly, at 1-year of follow-up, the cumulative event rate of the combined endpoint in the DE150 and warfarin was 8.9 and 15.9% respectively (p = 0.14). After adjustment for age and gender, patients who were treated with DE150 had a nonsignificant difference in the risk for the combined end point as patients treated with warfarin both among the elderly and among the younger population (HR 0.58, 95% C.I = 0.25–1.39 and HR = 1.12, 95% C.I 0.62–2.00, respectively [p for age-group-by-treatment interaction = 0.83). Conclusions: Our results suggest that Dabigatran 150 mg twice a day can be safely used among elderly AF patients with low bleeding risk.

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The association between hypoglycemia and glycemic variability in elderly patients with type 2 diabetes: a prospective observational study

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-021-00656-1 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Takahisa Handa ◽

Akinobu Nakamura ◽

Aika Miya ◽

Hiroshi Nomoto ◽

Hiraku Kameda ◽

...

Keyword(s):

Type 2 Diabetes ◽

Logistic Regression ◽

Regression Analysis ◽

Observational Study ◽

Elderly Patients ◽

Prospective Observational Study ◽

Multivariate Logistic Regression Analysis ◽

Glycemic Variability ◽

Multivariate Logistic Regression

Abstract Background This study aimed to explore predictive factors of time below target glucose range (TBR) ≥ 1% among patients’ characteristics and glycemic variability (GV) indices using continuous glucose monitoring data in elderly patients with type 2 diabetes. Methods We conducted a prospective observational study on 179 (71 female) Japanese outpatients with type 2 diabetes aged ≥ 65 years. The characteristics of the participants with TBR ≥ 1% were evaluated by multivariate logistic regression analysis. Receiver-operating characteristic (ROC) curve analyses of GV indices, comprising coefficient of variation (CV), standard deviation, and mean amplitude of glycemic excursions, were performed to identify the optimal index for the identification of patients with TBR ≥ 1%. Results In the multivariate logistic regression analysis, none of the clinical characteristics, including HbA1c and C-peptide index, were independent markers for TBR ≥ 1%, while all three GV indices showed significant associations with TBR ≥ 1%. Among the three GV indices, CV showed the best performance based on the area under the curve in the ROC curve analyses. Conclusions Among elderly patients with type 2 diabetes, CV reflected TBR ≥ 1% most appropriately among the GV indices examined. Trial registration UMIN-CTR: UMIN000029993. Registered 16 November 2017

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Rapid, Accurate and Novel Diagnostic Technique for Respiratory Pathogen: the Clinical Application of Loop-Mediated Isothermal Amplification Assay in Elderly Patients with Pneumonia, a Multicenter Prospective Observational Study

SSRN Electronic Journal ◽

10.2139/ssrn.4005135 ◽

2022 ◽

Author(s):

Shanchen Wei ◽

Lina Wang ◽

Mingwei Shi ◽

Jun Li ◽

Chunping Sun ◽

...

Keyword(s):

Observational Study ◽

Elderly Patients ◽

Clinical Application ◽

Prospective Observational Study ◽

Diagnostic Technique ◽

Isothermal Amplification ◽

Respiratory Pathogen ◽

Loop Mediated Isothermal Amplification ◽

Amplification Assay ◽

Multicenter Prospective Observational Study

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Evaluation of the impact of cataract surgery on cognitive function in very elderly patients: a prospective, observational study

Aging Clinical and Experimental Research ◽

10.1007/s40520-021-01962-4 ◽

2021 ◽

Author(s):

Tommaso Verdina ◽

Fabio Stiro ◽

Francesco Bruni ◽

Giorgio Alfredo Spedicato ◽

Rodolfo Mastropasqua ◽

...

Keyword(s):

Cognitive Function ◽

Observational Study ◽

Elderly Patients ◽

Cataract Surgery ◽

Prospective Observational Study ◽

Very Elderly ◽

The Impact

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ASSESSMENT OF MEDICATION ADHERENCE AMONG ELDERLY PATIENTS IN MYSURU CITY

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2019v11i5.35701 ◽

2019 ◽

pp. 41-46

Author(s):

JAIDEV KUMAR ◽

MAHENDRAPPA ◽

PRAMOD KUMAR

Keyword(s):

Medication Adherence ◽

Observational Study ◽

Elderly Patients ◽

Prospective Observational Study ◽

Research Study ◽

Medical Condition ◽

Good Adherence ◽

Oral Feedback ◽

One Year ◽

Age Range

Objective: To assess medication adherence among patients with chronic diseases. Methods: This was a prospective observational study carried out over period of one year in mysuru city. The subjects who meet study criteria were enrolled in this research study. The enrolled subjects were administered with simplified medication adherence questionnaire. The criteria to establish adherent and non-adherent were calculated as per simplified medication adherence questionnaire directions. Results: The gender distribution of this research study was reflected with male accountable for 45.63 % followed by female 54.36%. Asper simplified medication adherence questionnaire88% were adherent and remaining 12% were non-adherent in this research study. Conclusion: Patients with good adherence in this research study showed that they have good literacy status as well as better awareness about the existing medical condition and more consciousness may be there among these patients, what will be going to happen if their medical condition is left untreated.46.29 % males and 59.58 % females were adherent in this research study followed by 59.24% were adherent in the age range of 60-70 y as they were more conscious and less forgetfulness about medications as per the directions given by patient consultant which was oral feedback taken by research investigators during medication review in subjects home.

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