Exosomes derived from mesenchymal stem cells attenuate inflammation and demyelination of the central nervous system in EAE rats by regulating the polarization of microglia

Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system. Umbilical cord derived mesenchymal stem cells are immunosuppressive. We transplanted mesenchymal stem cells in a patient with refractory progressive MS, and the disease course was stabilized after the transplantation. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.

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Transplantation of mesenchymal stem cells promotes the functional recovery of the central nervous system following cerebral ischemia by inhibiting myelin-associated inhibitor expression and neural apoptosis

Experimental and Therapeutic Medicine ◽

10.3892/etm.2016.3089 ◽

2016 ◽

Vol 11 (5) ◽

pp. 1595-1600 ◽

Cited By ~ 11

Author(s):

NIANPING FENG ◽

GUANG HAO ◽

FENGGANG YANG ◽

FUJUN QU ◽

HAIHONG ZHENG ◽

...

Keyword(s):

Stem Cells ◽

Central Nervous System ◽

Nervous System ◽

Mesenchymal Stem Cells ◽

Cerebral Ischemia ◽

Functional Recovery ◽

The Central Nervous System ◽

Neural Apoptosis

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Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways

International Journal of Molecular Sciences ◽

10.3390/ijms20236039 ◽

2019 ◽

Vol 20 (23) ◽

pp. 6039 ◽

Cited By ~ 4

Author(s):

Luigi Chiricosta ◽

Serena Silvestro ◽

Jacopo Pizzicannella ◽

Francesca Diomede ◽

Placido Bramanti ◽

...

Keyword(s):

Stem Cells ◽

Central Nervous System ◽

Nervous System ◽

Mesenchymal Stem Cells ◽

Tnf Α ◽

The Central Nervous System ◽

Anti Inflammatory ◽

Next Generation Sequencing Ngs ◽

Generation Sequencing ◽

Stat Pathway

Inflammation is a common feature of many neurodegenerative diseases. The treatment of stem cells as a therapeutic approach to repair damage in the central nervous system represents a valid alternative. In this study, using Next-Generation Sequencing (NGS) technology, we analyzed the transcriptomic profile of human Gingival Mesenchymal Stem Cells (hGMSCs) treated with Moringin [4-(α-l-ramanosyloxy)-benzyl isothiocyanate] (hGMSCs-MOR) or with Cannabidiol (hGMSCs-CBD) at dose of 0.5 or 5 µM, respectively. Moreover, we compared their transcriptomic profiles in order to evaluate analogies and differences in pro- and anti-inflammatory pathways. The hGMSCs-MOR selectively downregulate TNF-α signaling from the beginning, reducing the expression of TNF-α receptor while hGMSCs-CBD limit its activity after the process started. The treatment with CBD downregulates the pro-inflammatory pathway mediated by the IL-1 family, including its receptor while MOR is less efficient. Furthermore, both the treatments are efficient in the IL-6 signaling. In particular, CBD reduces the effect of the pro-inflammatory JAK/STAT pathway while MOR enhances the pro-survival PI3K/AKT/mTOR. In addition, both hGMSCs-MOR and hGMSCs-CBD improve the anti-inflammatory activity enhancing the TGF-β pathway.

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