23.3 DIFFERENCES IN EMOTION REGULATION AND SOCIAL NEURAL PROCESSING IN ANXIOUS YOUTH AT HIGH FAMILIAL RISK FOR BIPOLAR DISORDER

2020 ◽  
Vol 59 (10) ◽  
pp. S197-S198
Author(s):  
Ewelina A. Migut ◽  
Rose-Marie T. Larios ◽  
Blake Novy ◽  
Crystal Franklin ◽  
Amy S. Garrett ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Emotion Regulation ◽  
Familial Risk ◽  
Neural Processing ◽  
Anxious Youth

Altered Social Cognitive Neural Processing During Social Exclusion in Anxious Youth at High Familial Risk for Bipolar Disorder

2020 ◽  
Vol 87 (9) ◽  
pp. S141-S142
Author(s):  
Blake Novy ◽  
Rose Marie Larios ◽  
Crystal Franklin ◽  
Ewelina Migut ◽  
Amy Garrett ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Social Exclusion ◽  
Social Cognitive ◽  
Familial Risk ◽  
Neural Processing ◽  
Anxious Youth

scholarly journals Network-level functional topological changes after mindfulness-based cognitive therapy in mood dysregulated adolescents at familial risk for bipolar disorder: a pilot study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kun Qin ◽  
Du Lei ◽  
Jing Yang ◽  
Wenbin Li ◽  
Maxwell J. Tallman ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Emotion Regulation ◽  
Cognitive Therapy ◽  
Path Length ◽  
Small Sample Size ◽  
Functional Integration ◽  
Familial Risk ◽  
Small Sample ◽  
Adverse Outcomes ◽  
Characteristic Path Length

Abstract Background Given that psychopharmacological approaches routinely used to treat mood-related problems may result in adverse outcomes in mood dysregulated adolescents at familial risk for bipolar disorder (BD), Mindfulness-Based Cognitive Therapy for Children (MBCT-C) provides an alternative effective and safe option. However, little is known about the brain mechanisms of beneficial outcomes from this intervention. Herein, we aimed to investigate the network-level neurofunctional effects of MBCT-C in mood dysregulated adolescents. Methods Ten mood dysregulated adolescents at familial risk for BD underwent a 12-week MBCT-C intervention. Resting-state functional magnetic resonance imaging (fMRI) was performed prior to and following MBCT-C. Topological metrics of three intrinsic functional networks (default mode network (DMN), fronto-parietal network (FPN) and cingulo-opercular network (CON)) were investigated respectively using graph theory analysis. Results Following MBCT-C, mood dysregulated adolescents showed increased global efficiency and decreased characteristic path length within both CON and FPN. Enhanced functional connectivity strength of frontal and limbic areas were identified within the DMN and CON. Moreover, change in characteristic path length within the CON was suggested to be significantly related to change in the Emotion Regulation Checklist score. Conclusions 12-week MBCT-C treatment in mood dysregulated adolescents at familial risk for BD yield network-level neurofunctional effects within the FPN and CON, suggesting enhanced functional integration of the dual-network. Decreased characteristic path length of the CON may be associated with the improvement of emotion regulation following mindfulness training. However, current findings derived from small sample size should be interpreted with caution. Future randomized controlled trials including larger samples are critical to validate our findings.

scholarly journals Deficits in explicit emotion regulation in bipolar disorder: a systematic review

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Marcel Kurtz ◽  
Pia Mohring ◽  
Katharina Förster ◽  
Michael Bauer ◽  
Philipp Kanske
Keyword(s):  
At Risk ◽  
Bipolar Disorder ◽  
Emotion Regulation ◽  
Mood State ◽  
Bipolar Disorders ◽  
Protective Measure ◽  
Behavioral Measures ◽  
Increased Risk ◽  
Regulation Strategies ◽  
Depressive Episodes

Abstract Background This study aimed to compile and synthesize studies investigating explicit emotion regulation in patients with bipolar disorder and individuals at risk of developing bipolar disorder. The importance of explicit emotion regulation arises from its potential role as a marker for bipolar disorders in individuals at risk and its potent role in therapy for bipolar disorder patients. Methods To obtain an exhaustive compilation of studies dealing specifically with explicit emotion regulation in bipolar disorder, we conducted a systematic literature search in four databases. In the 15 studies we included in our review, the emotion-regulation strategies maintenance, distraction, and reappraisal (self-focused and situation-focused) were investigated partly on a purely behavioral level and partly in conjunction with neural measures. The samples used in the identified studies included individuals at increased risk of bipolar disorder, patients with current affective episodes, and patients with euthymic mood state. Results In summary, the reviewed studies' results indicate impairments in explicit emotion regulation in individuals at risk for bipolar disorder, patients with manic and depressive episodes, and euthymic patients. These deficits manifest in subjective behavioral measures as well as in neural aberrations. Further, our review reveals a discrepancy between behavioral and neural findings regarding explicit emotion regulation in individuals at risk for bipolar disorders and euthymic patients. While these groups often do not differ significantly in behavioral measures from healthy and low-risk individuals, neural differences are mainly found in frontostriatal networks. Conclusion We conclude that these neural aberrations are a potentially sensitive measure of the probability of occurrence and recurrence of symptoms of bipolar disorders and that strengthening this frontostriatal route is a potentially protective measure for individuals at risk and patients who have bipolar disorders.

Emotion regulation in pediatric bipolar disorder: A meta-analysis of published studies

2021 ◽  
Vol 285 ◽  
pp. 86-96
Author(s):  
Tatiana Cohab Khafif ◽  
Luisa de Siqueira Rotenberg ◽  
Camila Nascimento ◽  
Gabriel Henrique Beraldi ◽  
Beny Lafer
Keyword(s):  
Bipolar Disorder ◽  
Emotion Regulation ◽  
Meta Analysis ◽  
Pediatric Bipolar Disorder

Emotion regulation in bipolar disorder: Profile and utility in predicting trait mania and depression propensity

2015 ◽  
Vol 225 (3) ◽  
pp. 425-432 ◽  
Author(s):  
Tamsyn E. Van Rheenen ◽  
Greg Murray ◽  
Susan L. Rossell
Keyword(s):  
Bipolar Disorder ◽  
Emotion Regulation

scholarly journals Lack of cortico-limbic coupling in bipolar disorder and schizophrenia during emotion regulation

2012 ◽  
Vol 2 (3) ◽  
pp. e90-e90 ◽  
Author(s):  
R W Morris ◽  
A Sparks ◽  
P B Mitchell ◽  
C S Weickert ◽  
M J Green
Keyword(s):  
Bipolar Disorder ◽  
Emotion Regulation

scholarly journals Multiple sclerosis and psychiatric disorders: Comorbidity and sibling risk in a nationwide Swedish cohort

2014 ◽  
Vol 20 (14) ◽  
pp. 1881-1891 ◽  
Author(s):  
Viktoria Johansson ◽  
Cecilia Lundholm ◽  
Jan Hillert ◽  
Thomas Masterman ◽  
Paul Lichtenstein ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Bipolar Disorder ◽  
Psychiatric Disorders ◽  
Psychiatric Patients ◽  
Familial Risk ◽  
Positive Association ◽  
Protective Mechanisms ◽  
Genetic Liability ◽  
Sibling Comparison ◽  
National Patient

Background: Psychiatric disorders are known to be prevalent in multiple sclerosis (MS). Objective: The objective of this paper is to study comorbidity between MS and bipolar disorder, schizophrenia and depression in a nationwide cohort and to determine whether shared genetic liability underlies the putative association. Methods: We identified ICD-diagnosed patients with MS ( n = 16,467), bipolar disorder ( n = 30,761), schizophrenia ( n = 22,781) and depression ( n = 172,479) in the Swedish National Patient Register and identified their siblings in the Multi-Generation Register. The risk of MS was compared in psychiatric patients and in matched unexposed individuals. Shared familial risk between MS and psychiatric disorders was estimated by sibling comparison. Results: The risk of MS was increased in patients with bipolar disorder (hazard ratio (HR) 1.8, 95% confidence interval (CI) 1.6–2.2, p < 0.0001) and depression (HR 1.9, 95% CI 1.7–2.0, p < 0.0001). MS risk in schizophrenia was decreased (HR 0.6, 95% CI 0.4–0.9, p = 0.005). The association between having a sibling with a psychiatric disorder and developing MS was not significant. Conclusion: We found a strong positive association between MS and bipolar disorder and depression that could not be explained by genetic liability. The unexpected negative association between MS and schizophrenia might be spurious or indicate possible protective mechanisms that warrant further exploration.

scholarly journals 208. Behavioral and Neural Sustained Attention Deficits in Bipolar Disorder and Familial Risk of Bipolar Disorder

2018 ◽  
Vol 83 (9) ◽  
pp. S84 ◽  
Author(s):  
David Pagliaccio ◽  
Jillian Wiggins ◽  
Nancy Adleman ◽  
Elizabeth Harkins ◽  
Alexa Curhan ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Sustained Attention ◽  
Familial Risk ◽  
Attention Deficits

Neural responses during down-regulation of negative emotion in patients with recently diagnosed bipolar disorder and their unaffected relatives

2021 ◽  
pp. 1-12
Author(s):  
Hanne Lie Kjærstad ◽  
Julian Macoveanu ◽  
Gitte Moos Knudsen ◽  
Sophia Frangou ◽  
K. Luan Phan ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Emotion Regulation ◽  
Functional Connectivity ◽  
Neural Activity ◽  
Negative Emotion ◽  
Negative Emotions ◽  
Imaging Study ◽  
Neural Responses ◽  
Functional Magnetic Resonance ◽  
Down Regulation

Abstract Background Aberrant emotion regulation has been posited as a putative endophenotype of bipolar disorder (BD). We therefore aimed to compare the neural responses during voluntary down-regulation of negative emotions in a large functional magnetic resonance imaging study of BD, patients' unaffected first-degree relatives (URs), and healthy controls (HCs). Methods We compared neural activity and fronto-limbic functional connectivity during emotion regulation in response to aversive v. neutral pictures in patients recently diagnosed with BD (n = 78) in full/partial remission, their URs (n = 35), and HCs (n = 56). Results Patients showed hypo-activity in the left dorsomedial, dorsolateral, and ventrolateral prefrontal cortex (DMPFC and DLPFC) during emotion regulation while viewing aversive pictures compared to HCs, with URs displaying intermediate neural activity in these regions. There were no significant differences between patients with BD and HCs in functional connectivity from the amygdala during emotion regulation. However, exploratory analysis indicated that URs displayed more negative amygdala–DMPFC coupling compared with HCs and more negative amygdala-cingulate DLPFC coupling compared to patients with BD. At a behavioral level, patients and their URs were less able to dampen negative emotions in response aversive pictures. Conclusions The findings point to deficient recruitment of prefrontal resources and more negative fronto-amygdala coupling as neural markers of impaired emotion regulation in recently diagnosed remitted patients with BD and their URs, respectively.

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