RSV-induced cytokine response patterns in cord blood and clinical manifestations of RSV infections in the first year of life*1

Cord blood 25-hydroxyvitamin D (25OHD) has been reported in association with risk of early life recurrent wheeze. In a subset of infants who participated in the Vitamin D Antenatal Asthma Reduction Trial, we demonstrated that higher cord blood 25OHD at birth (>31 ng/mL) was associated with a reduced risk of recurrent wheeze in the first year of life. We then identified a module of co-expressed genes associated with cord blood 25OHD levels >31 ng/mL. Genes in this module are involved in biological and immune pathways related to development and progression of asthma pathogenesis including the Notch1 and transforming growth factor-beta signalling pathways.

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Leptin levels at birth and infant growth: the EPOCH study

Journal of Developmental Origins of Health and Disease ◽

10.1017/s204017441400021x ◽

2014 ◽

Vol 5 (3) ◽

pp. 214-218 ◽

Cited By ~ 16

Author(s):

J. L. Kaar ◽

J. T. Brinton ◽

T. Crume ◽

R. F. Hamman ◽

D. H. Glueck ◽

...

Keyword(s):

Cord Blood ◽

Perinatal Outcomes ◽

Epidemiological Studies ◽

In Utero ◽

Feedback Mechanism ◽

Infant Growth ◽

Sufficient Evidence ◽

First Year ◽

First Year Of Life ◽

Maternal Overweight

Objective: To examine the association of cord blood leptin with body mass index (BMI) growth velocity from birth to 12 months of age among infants exposed and not exposed to over-nutrition in utero (defined as maternal overweight/obesity or presence of gestational diabetes). Methods: 185 infants enrolled in the Exploring Perinatal Outcomes among Children study (76 exposed and 109 not exposed) had leptin and insulin measured in cord blood. Longitudinal weight and length measures in the first 12 months of life (average 4 per participant) obtained from medical records were used to compute BMI growth rates. Mixed models were used to examine associations of cord blood leptin with growth. Results: Compared with unexposed infants, those exposed had significantly higher cord blood insulin (8.64 v. 6.97 uU/ml, P<0.01) and leptin levels (8.89 v. 5.92 ng/ml, P=0.05) as well as increased birth weights (3438.04 v. 3306.89 g, P=0.04). There was an inverse relationship between cord leptin levels and BMI growth from birth to 12 months of age (P=0.005); however, exposure to over-nutrition in utero did not significantly modify this association (P=0.59). Conclusion: We provide support of a possible operational feedback mechanism by which lower cord blood leptin levels are associated with faster infant growth in the first year of life. Our data do not tend to support the hypothesis that this mechanism is altered in infants exposed to over-nutrition in utero; however our sample is too small to provide sufficient evidence. Larger epidemiological studies are needed to elucidate the mechanisms responsible for increased propensity for obesity in exposed offspring.

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Unrelated Cord Blood Transplantation for Acute Leukemia Diagnosed in the First Year of Life: Outcomes and Risk Factor Analysis

Biology of Blood and Marrow Transplantation ◽

10.1016/j.bbmt.2016.10.014 ◽

2017 ◽

Vol 23 (1) ◽

pp. 96-102 ◽

Cited By ~ 2

Author(s):

Annalisa Ruggeri ◽

Fernanda Volt ◽

Franco Locatelli ◽

Gerard Michel ◽

Cristina Diaz de Heredia ◽

...

Keyword(s):

Factor Analysis ◽

Risk Factor ◽

Acute Leukemia ◽

Cord Blood ◽

Cord Blood Transplantation ◽

First Year ◽

Life Outcomes ◽

Blood Transplantation ◽

Unrelated Cord Blood ◽

First Year Of Life

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Three-Year Clinical Follow-Up of Children Intrauterine Exposed to Zika Virus

Viruses ◽

10.3390/v13030523 ◽

2021 ◽

Vol 13 (3) ◽

pp. 523

Author(s):

Rosa Estela Gazeta ◽

Ana Paula Antunes Pascalicchio Bertozzi ◽

Rita de Cássia de Aguirre Bernardes Dezena ◽

Andrea Cristina Botelho Silva ◽

Thamirys Cosmo Gillo Fajardo ◽

...

Keyword(s):

Zika Virus ◽

Clinical Manifestations ◽

Laboratory Diagnosis ◽

Autism Spectrum ◽

First Year ◽

Cognitive Delay ◽

Long Term Follow Up ◽

Simplex Virus ◽

First Year Of Life

Congenital Zika virus (ZIKV) infection may present with a broad spectrum of clinical manifestations. Some sequelae, particularly neurodevelopmental problems, may have a later onset. We conducted a prospective cohort study of 799 high-risk pregnant women who were followed up until delivery. Eighty-three women and/or newborns were considered ZIKV exposed and/or infected. Laboratory diagnosis was made by polymerase chain reaction in the pregnant mothers and their respective newborns, as well as Dengue virus, Chikungunya virus, and ZIKV serology. Serology for toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus, and syphilis infections were also performed in microcephalic newborns. The newborns included in the study were followed up until their third birthday. Developmental delay was observed in nine patients (13.2%): mild cognitive delay in three patients, speech delay in three patients, autism spectrum disorder in two patients, and severe neurological abnormalities in one microcephalic patient; sensorineural hearing loss, three patients and dysphagia, six patients. Microcephaly due to ZIKV occurred in three patients (3.6%). Clinical manifestations can appear after the first year of life in children infected/exposed to ZIKV, emphasizing the need for long-term follow-up.

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Prediction of atopy in the first year of life using cord blood IgE levels and family history

European Journal of Medical Research ◽

10.1186/2047-783x-14-s4-227 ◽

2009 ◽

Vol 14 (Suppl 4) ◽

pp. 227 ◽

Cited By ~ 5

Author(s):

AJ Sybilski ◽

A Doboszynska ◽

B Samolinski

Keyword(s):

Family History ◽

Cord Blood ◽

First Year ◽

First Year Of Life

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Clinical manifestations of familial exudative vitreoretinopathy in the first year of life

Russian Ophthalmological Journal ◽

10.21516/2072-0076-2021-14-3-8-13 ◽

2021 ◽

Vol 14 (3) ◽

pp. 8-13

Author(s):

L. A. Katargina ◽

E. V. Denisova ◽

E. A. Geraskina

Keyword(s):

Clinical Manifestations ◽

First Year ◽

Familial Exudative Vitreoretinopathy ◽

First Year Of Life

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Investigation of the possible effectiveness of osteopathic correction in the complex treatment of children in the first year of life with hip dysplasia

Russian Osteopathic Journal ◽

10.32885/2220-0975-2021-4-39-49 ◽

2021 ◽

pp. 39-49

Author(s):

N. A. Fabristova ◽

I. R. Gainullin

Keyword(s):

Hip Dysplasia ◽

Standard Treatment ◽

Clinical Manifestations ◽

Standards Of Care ◽

First Year ◽

Complex Treatment ◽

Hip Joints ◽

Congenital Diseases ◽

Detection Frequency ◽

First Year Of Life

Introduction. Congenital dysplasia of the hip joints is one of the main among congenital diseases of the musculoskeletal system in children and requires a long period of treatment, including in a hospital settings. Standard methods of treatment contain the orthopedic and rehabilitation measures: the use of abduction splints, a complex of physiotherapy exercises, general massage, the use of various physiotherapeutic procedures. Osteopathic correction is not included in the standards of care for this category of patients. At the same time, these standard treatment methods do not always give a desired result, and sometimes even lead to the development of complications. All this facts determines the need to search for additional therapeutic techniques.The aim of the study is to research the possible effectiveness of osteopathic correction as part of the complex treatment of children in the first year of life with hip dysplasia.Materials and methods. The study included 34 children with a diagnosis of hip dysplasia (ICD code-10 — Q65.8). The patients were randomly divided into 2 equivalent groups: study and control. Participants in both groups received standard treatment; the participants of the main group additionally underwent osteopathic correction of the revealed somatic dysfunctions. Before and after the course of treatment, the patients' osteopathic status, the disease clinical manifestations, and the X-ray data of the hip joints were assessed.Results. The inclusion of osteopathic correction in the complex with standard treatment procedures for children of the first year of life with hip dysplasia is accompanied by a statistically significant decrease in the detection frequency of the somatic dysfunctions at the regional and local levels. The median duration of standard orthopedic treatment also decreases (p<0,05).Conclusion. The obtained results demonstrate that the inclusion of osteopathic correction in the complex treatment of children in the first year of life with hip dysplasia shortens the treatment time for patients. It is recommended to continue research in this direction with a larger sample size.

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Cord blood Interleukin-13 and IFN-Gamma levels As Biomarkers of Ever-Wheezing in the First Year of Life

10.1183/13993003.congress-2020.1215 ◽

2020 ◽

Author(s):

Özge Yılmaz ◽

Adem Yaşar ◽

Pınar Ay ◽

Arzu Çalışkan Polat ◽

Ferhan Odabaşı Cingöz ◽

...

Keyword(s):

Cord Blood ◽

First Year ◽

Ifn Gamma ◽

Interleukin 13 ◽

First Year Of Life

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