Expression network analysis reveals cord blood vitamin D-associated genes affecting risk of early life wheeze
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Cord blood 25-hydroxyvitamin D (25OHD) has been reported in association with risk of early life recurrent wheeze. In a subset of infants who participated in the Vitamin D Antenatal Asthma Reduction Trial, we demonstrated that higher cord blood 25OHD at birth (>31 ng/mL) was associated with a reduced risk of recurrent wheeze in the first year of life. We then identified a module of co-expressed genes associated with cord blood 25OHD levels >31 ng/mL. Genes in this module are involved in biological and immune pathways related to development and progression of asthma pathogenesis including the Notch1 and transforming growth factor-beta signalling pathways.
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2018 ◽
Vol 104
(2)
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pp. 397-407
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2013 ◽
Vol 110
(10)
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pp. 1895-1902
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2019 ◽
Vol 7
(1)
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pp. 65-67
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1974 ◽
Vol 84
(5)
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pp. 742-749
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