Long-Term Follow Up of Bi-Weekly Lipoprotein Apheresis in A patient with Elevated Lipoprotein-(a) Shows Regression in Carotid Intima-Media Thickness

IntroductionAccelerated atherosclerosis is a major complication of systemic lupus erythematosus (SLE), and it leads to increased cardiovascular morbidity and mortality in patients with SLE. This study aimed to investigate the natural progression of carotid intima-media thickness (CIMT), and to examine the risk factors for progression of CIMT and atherosclerotic plaques based on a Chinese SLE cohort.Methods and analysisParticipants were continuously enrolled as outpatients of the Department of Rheumatology in Peking Union Medical College Hospital (PUMCH) from October 2013 to December 2016. Inclusion criteria were as follows: (1) age ≥18 years, (2) fulfilment of clinical classification criteria of SLE and (3) provision of signed written informed consent. Patients with clinically overt coronary artery disease, a history of cardiovascular disease (previous stroke, heart failure, myocardial infarction, angina or symptomatic peripheral artery disease) and malignancy, and pregnant/lactating women were excluded. The primary outcome is progression of CIMT from baseline. A total of 440 patients with SLE will be enrolled. Participants will receive follow-up surveys ~5 years after their baseline visit. A standard structural survey form, including demographic data, medical history, clinical and laboratory assessments and CIMT measurement, is planned for data collection at baseline and follow-up. The risk prediction model for progression of CIMT will be created by using a mixed effect model.Ethics and disseminationThe study protocol was approved by the institutional review board of PUMCH (S-599). Informed consent was obtained from all participants according to the Declaration of Helsinki on Biomedical Research Involving Human Studies. All data will be managed confidentially according to guidelines and legislation. Dissemination will include publication of scientific papers and/or presentations of the study findings at international conferences.

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Lipoprotein-A and carotid intima media thickness as cardiovascular risk factors in patients of chronic kidney disease

Renal Failure ◽

10.3109/0886022x.2010.486097 ◽

2010 ◽

Vol 32 (6) ◽

pp. 647-652 ◽

Cited By ~ 10

Author(s):

Hari Krishan Aggarwal ◽

Deepak Jain ◽

Mohit Lathar ◽

R.K. Yadav ◽

Amrish Sawhney

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Cardiovascular Risk ◽

Kidney Disease ◽

Cardiovascular Risk Factors ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Lipoprotein A ◽

Media Thickness

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Coronary Artery Calcification Is Related to Inflammation in Rheumatoid Arthritis: A Long-Term Follow-Up Study

BioMed Research International ◽

10.1155/2016/1261582 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 10

Author(s):

Bengt Wahlin ◽

Thomas Meedt ◽

Fredrik Jonsson ◽

Michael Y. Henein ◽

Solveig Wållberg-Jonsson

Keyword(s):

Rheumatoid Arthritis ◽

Coronary Artery ◽

Coronary Artery Calcification ◽

Intima Media Thickness ◽

Projection To Latent Structures ◽

Follow Up Study ◽

Long Term Follow Up ◽

Latent Structures

Objective. A long-term follow-up of patients with rheumatoid arthritis (RA) to evaluate factors related to coronary artery calcification (CAC).Methods. All 22 eligible patients (4 males/18 females, mean age 65 years, and RA-duration 30–36 years) from the original (baseline;n=39) study of atherosclerosis were included. Inflammation, cardiovascular risk factors, and biomarkers were measured at baseline. At follow-up 13 years later, CAC was assessed by computed tomography (CT) and the grade of inflammation was measured. Multivariate analysis of differences between patients with low (0–10) and high CAC (>10) was done by orthogonal projection to latent structures (OPLS).Results. Ten patients had CAC 0–10 and 12 had >10 (range 18–1700). Patients with high CAC had significantly higher ESR (24.3 versus 9.9 mm/h) and swollen joint count (2 versus 0). The OPLS models discriminated between patients having high or low CAC. With only baseline variables, the sensitivity was 73% and the specificity 82%. The model that also included inflammatory variables from follow-up had a sensitivity of 89% and a specificity of 85%. Exclusion of baseline intima media thickness and plaque from the latter model modestly reduced the accuracy (sensitivity 80% and specificity 83%).Conclusions. CAC is related to inflammation in patients with RA.

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Incense Smoke and Increasing Carotid Intima Media Thickness: A Cross-Sectional Study of the Thai-Vietnamese Community

Asia Pacific Journal of Public Health ◽

10.1177/1010539517753930 ◽

2018 ◽

Vol 30 (2) ◽

pp. 178-187 ◽

Cited By ~ 2

Author(s):

Rattanee Kammoolkon ◽

Nutta Taneepanichskul ◽

Nattaporn Pitaknoppakul ◽

Somrat Lertmaharit ◽

Vitool Lohsoonthorn

Keyword(s):

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Cross Sectional Study ◽

Exposed Group ◽

Mean Difference ◽

Sectional Study ◽

Cross Sectional ◽

Media Thickness ◽

Incense Burning

Incense burning, a source of household indoor air pollution, is possible to effect on cardiovascular system. Our study sought to examine the association of long-term exposure to household incense smoke with increased carotid intima-media thickness (CIMT). A cross-sectional study was conducted 132 adults aged ≥35 years. Participants were stratified into 3 groups by their long-term household incense use; nonexposed group, non–daily exposed group, and daily exposed group. A combined mean CIMT (mean difference = 0.04 mm; P < .01) and combined maximum CIMT (mean difference = 0.09 mm; P < .01) in the daily exposed group had greater than the nonexposed group. The mean CIMT and maximum CIMT of the left common carotid artery in the daily exposed group was significantly greater than the nonexposed group ( P < .01). These findings suggest that incense burning inside the house may be a risk factor for cardiovascular disease morbidity and mortality.

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The association between carotid intima-media thickness and new-onset hypertension in a Chinese community-based population

BMC Cardiovascular Disorders ◽

10.1186/s12872-019-1266-1 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Long Zhang ◽

Fangfang Fan ◽

Litong Qi ◽

Jia Jia ◽

Ying Yang ◽

...

Keyword(s):

Blood Pressure ◽

Strong Association ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Incidence Rates ◽

Community Based ◽

Media Thickness ◽

The Mean ◽

New Onset

Abstract Background Hypertension and arterial vasculopathy may be mutual causes and effects. It is unknown whether carotid intima-media thickness (cIMT) is reliably predictive of the presence of newly developed hypertension in the Chinese population. This study evaluated the impacts of cIMT on new-onset hypertension in a community-based population without hypertension at baseline in China. Methods A total of 672 Chinese subjects who had complete data for demographics, baseline and follow-up blood pressure measurements, and cIMT measurements at baseline were included in our study. Baseline cIMT was obtained under standardized procedures using the GE Vivid 7 ultrasound system equipped with an 8-MHz linear array vascular probe (GE Medical Systems, Milwaukee, Wl, USA). The outcome was the incidence of hypertension at follow-up. Multivariate regression models were used to access the association between baseline cIMT and the risk of new-onset hypertension. Results Subjects were 51.5 ± 4.7 years old, and 32.0% were male. The mean baseline systolic blood pressure (SBP) was 122.5 ± 10.0 mmHg. The mean baseline diastolic blood pressure (DBP) was 72.4 ± 7.5 mmHg. The number of subjects with thickened cIMT (maximum ≥0.9 mm) at baseline was 198 (29.5%). After 2.3 years of follow-up, the rate of new-onset hypertension was 12.6%. The incidence rates of hypertension in the groups with thickened cIMT and normal cIMT were 19.2 and 9.9%, respectively. In the multivariable logistic regression analyses, both the average (OR = 1.69, 95% CI: 1.30–2.19, P = 0.0001) and maximum (OR = 1.55, 95% CI: 1.23–1.95, P = 0.0002) cIMT were significantly associated with new-onset hypertension after adjustment for various confounders. The group with thickened cIMT showed a higher risk for the incidence of hypertension, with an OR of 1.82 (95% CI: 1.07–3.10, P = 0.0270), compared to the normal group. Conclusion Thickened cIMT has a strong association with incident hypertension risk in a community-based population without hypertension at baseline in China.

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