Irritability and mental health profiles among children and adolescents: A result of latent profile analysis

Author(s):  
Kohei Kishida ◽  
Masami Tsuda ◽  
Fumito Takahashi ◽  
Shin-ichi Ishikawa
2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 637-637
Author(s):  
Hyunyup Lee ◽  
Carolyn Aldwin ◽  
Sungrok Kang ◽  
Xyle Ku

Abstract We investigated the dimensional structure of mental health among aging Korean Veterans using latent profile analysis (LPA) on posttraumatic stress disorder symptoms (PTSD), late onset stress symptomology (LOSS), and psychosocial well-being (PWB). The Korean Vietnam War Veterans Study consists of 367 men (Mage=72, SD=2.66). LPA identified five classes of mental health as best fitting the data. Most men were in the normal (38%) and moderate distress (31%) groups, while smaller proportions were in the low affect (13%) and severe distress (7%) groups. The resilient group (12%) had low PTSD, medium LOSS, and high PWB, and were highest on optimism, positive appraisals of military service, and social support. Negative and positive aspects of mental health outcomes were on separate dimensions rather than on a single bipolar dimension. Service providers should attempt to both reduce Veterans’ negative psychological symptoms and increase psychosocial well-being. Part of a symposium sponsored by the Aging Veterans: Effects of Military Service across the Life Course Interest Group.


2021 ◽  
Vol 12 ◽  
Author(s):  
Jasmina Mehulić ◽  
Željka Kamenov

The ongoing coronavirus disease-2019 (COVID-19) pandemic presents an acute stressor affecting mental health. In these stressful times, intimate relationships functioning could serve as a protective or a risk factor to the well-being of partners. Adult Croatian citizens engaged in intimate relationships (N = 727) reported their relationship characteristics and assessed symptoms of depression, anxiety, and stress during the state lockdown in May 2020. Three relationship profiles based on variations in key relationship characteristics were identified using latent profile analysis. Profiles represented distinct relationship types described as affectionate, ambivalent, and antagonistic relationships. These relationship types differed in their levels of love and perception of humility, responsiveness, and behavior of the partner. Relationship type was associated with mental health symptoms such as depression, anxiety, and stress during the COVID-19 pandemic and state lockdown. Being in an affectionate relationship was associated with the lowest levels of depression, anxiety, and stress, while in an antagonistic relationship these are in the highest levels. Ambivalent relationships were characterized by moderate levels on all measured mental health indicators with no difference in anxiety compared with affectionate relationships. The results emphasized the link between relationship functioning and successful coping with mental health hazards such as the fear of disease or restrictive measures put in place to contain the COVID-19 pandemic.


2016 ◽  
Vol 33 (S1) ◽  
pp. S19-S19
Author(s):  
M. Nobile

ObjectivesAssociation studies have implicated the N-methyl-D-aspartate receptor 2B subunit gene (GRIN2B) as candidate for different brain illnesses, also including both internalizing and externalizing disorders. Here, we explored the association between selected SNPs of GRIN2B (rs5796555-/A; rs1012586C/G; rs2268119A/T; rs2216128A/G; rs11609779C/T; rs2192973G/A) and attention problems in children an adolescents as assessed by CBCL 6/18 (Achenbach and Rescorla, 2001).MethodsIn a large cohort of 320 Italian nuclear families selected from an ongoing comprehensive project on child and adolescent psychopathology performed at two sites of our Institutes (BP and UD), we performed a family-based association study to determine whether the GRIN2B gene influence and/or mediates susceptibility to attention problems through time. Genetic association was investigated by the quantitative transmission disequilibrium test (QTDT, version 2.5.1; Abecasis et al., 2000). Quantitative traits were analyzed using the ‘-wega’ and the ‘-ao’ options. Empirical P-values were computed from 10,000 Monte-Carlo permutations, and the significance levels were adjusted by the false discovery rate method (Storey, 2002) applied to the tests performed for each marker (i.e., 8 phenotypes) at two different point times. Latent profile analysis was performed to assess the effect of gene on different trajectories over time. The effect of environmental determinants was also evaluated.ResultsEvidence for significant association of GRIN2B-rs5796555-/A was found with attention problems both at first and second evaluation. Latent profile analysis suggested significant association with specific trajectories and specific environmental factors.ConclusionsThese results provide preliminary evidence of an association between the GRIN2B polymorphism and continuity of attention problems throughout adolescence within an Italian population of referred children and adolescents, suggesting that the GRIN2B genes could play a role in susceptibility to attention problems during developmental age.Disclosure of interestThe author has not supplied his declaration of competing interest.


2021 ◽  
Vol 18 (6) ◽  
pp. 580-588
Author(s):  
Yue Wang ◽  
Fenfen Ge ◽  
Mentong Wan ◽  
Jun Zhang

Objective Depression and resilience are different psychological outcomes caused by experiencing traumatic events. We aimed to 1) explore heterogeneity patterns of co-occurrence between depression symptoms and resilience among children and adolescents exposed to an earthquake and 2) assess covariates (trauma exposure, sex, age, ethnicity, and sleep quality) in identifying the best fitting solution. Methods Latent profile analysis (LPA) was used to examine patterns of self-reported depression and resilience in an epidemiological sample of 2,887 Chinese youth survivors 1 year after the Lushan earthquake. Results A suitable 3-class model were identified, which are mild depression/high resilience (65.0%), severe depression/high resilience (22.1%), and severe depression/low resilience (12.9%). Trauma exposure, demographic characteristics and sleep state can be used to identify the different latent classes. Conclusion Our results contribute to understanding the heterogeneous coexisting patterns of depression and resilience and provide suggestions for identifying high-risk youth survivors and offering effective interventions.


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