scholarly journals Asthma Diagnosis without Aerosol-Generating Procedures (Spirometry): Evidence for and Beyond the COVID-19 Pandemic

2021 ◽  
Vol 9 (12) ◽  
pp. 4252-4253
Author(s):  
Hannu Kankaanranta ◽  
Lauri Lehtimäki ◽  
Leena E. Tuomisto
Keyword(s):  
Nitric Oxide ◽  
2014 ◽  
Vol 40 ◽  
pp. 87-91 ◽  
Author(s):  
Joanna Jerzyńska ◽  
Paweł Majak ◽  
Anna Janas ◽  
Rafał Stelmach ◽  
Włodzimierz Stelmach ◽  
...  

2021 ◽  
pp. 108705472110201
Author(s):  
Douglas Teixeira Leffa ◽  
Bernardo Horta ◽  
Fernando C. Barros ◽  
Ana M. B. Menezes ◽  
Thais Martins-Silva ◽  
...  

Objective: Shared genetic mechanisms have been hypothesized to explain the comorbidity between ADHD and asthma. To evaluate their genetic overlap, we relied on data from the 1982 Pelotas birth cohort to test the association between polygenic risk scores (PRSs) for ADHD (ADHD-PRSs) and asthma, and PRSs for asthma (asthma-PRSs) and ADHD. Method: We analyzed data collected at birth, 2, 22, and 30 years from 3,574 individuals. Results: Subjects with ADHD had increased risk of having asthma (OR 1.92, 95% CI 1.01–3.66). The association was stronger for females. Our results showed no evidence of association between ADHD-PRSs and asthma or asthma-PRSs and ADHD. However, an exploratory analysis suggested that adult ADHD might be genetically associated with asthma. Conclusion: Our results do not support a shared genetic background between both conditions. Findings should be viewed in light of important limitations, particularly the sample size and the self-reported asthma diagnosis. Studies in larger datasets are required to better explore the genetic overlap between adult ADHD and asthma.


2021 ◽  
Vol 14 (10) ◽  
pp. e245233
Author(s):  
Diana Alexandra Pimenta ◽  
Filipa Lemos Aguiar ◽  
Beatriz Celeiros Fernandes ◽  
Rui Rolo

Pulmonary agenesis is defined as the complete absence of one or both lungs, including the bronchi, bronchioles, vasculature and lung parenchyma. Most of these malformations are detected in early childhood. A residual number remains asymptomatic and undiagnosed until adulthood. The clinical presentation is wide, ranging from asymptomatic to respiratory complaints like dyspnoea, respiratory distress and a history of recurrent lung infections. This case presents a 54-year-old woman with complaints of coughing, dyspnoea for medium exertion and wheezing for a couple of months. Based on the results of complementary diagnosis methods, right pulmonary agenesis was diagnosed without other malformations. Simultaneously, an asthma diagnosis was also performed. The treatment of pulmonary agenesis is symptomatic. Simultaneous cardiovascular malformations could require surgical interventions. This case demonstrates that pulmonary agenesis may remain undiagnosed, be identified incidentally, and have a good and long prognosis.


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