IC-P1-042: The impact of memory test scores and neuroimaging on the clinical diagnosis of Alzheimer's dementia

2008 ◽  
Vol 4 ◽  
pp. T25-T26
Author(s):  
Anne Rita H. Oksengard ◽  
Rimma Axelsson ◽  
Lena Cavallin ◽  
Christin Andersson ◽  
Katarina Nägga ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Test Scores ◽  
Alzheimer’S Dementia ◽  
Memory Test ◽  
Alzheimer's Dementia ◽  
The Impact

P3-036: The impact of memory test scores and neuroimaging on the clinical diagnosis of Alzheimer's dementia

2008 ◽  
Vol 4 ◽  
pp. T527-T527
Author(s):  
Anne Rita H. Oksengard ◽  
Rimma Axelsson ◽  
Lena Cavallin ◽  
Christin Andresson ◽  
Katarina Nägga ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Test Scores ◽  
Alzheimer’S Dementia ◽  
Memory Test ◽  
Alzheimer's Dementia ◽  
The Impact

scholarly journals The impact of bilingualism on brain reserve and metabolic connectivity in Alzheimer's dementia

2017 ◽  
Vol 114 (7) ◽  
pp. 1690-1695 ◽  
Author(s):  
Daniela Perani ◽  
Mohsen Farsad ◽  
Tommaso Ballarini ◽  
Francesca Lubian ◽  
Maura Malpetti ◽  
...  
Keyword(s):  
Neuroprotective Effect ◽  
Alzheimer’S Dementia ◽  
Synaptic Function ◽  
Compensatory Mechanisms ◽  
Neuroprotective Effects ◽  
Alzheimer's Dementia ◽  
Bilingual Speakers ◽  
Metabolic Connectivity ◽  
The Impact

Cognitive reserve (CR) prevents cognitive decline and delays neurodegeneration. Recent epidemiological evidence suggests that lifelong bilingualism may act as CR delaying the onset of dementia by ∼4.5 y. Much controversy surrounds the issue of bilingualism and its putative neuroprotective effects. We studied brain metabolism, a direct index of synaptic function and density, and neural connectivity to shed light on the effects of bilingualism in vivo in Alzheimer’s dementia (AD). Eighty-five patients with probable AD and matched for disease duration (45 German-Italian bilingual speakers and 40 monolingual speakers) were included. Notably, bilingual individuals were on average 5 y older than their monolingual peers. In agreement with our predictions and with models of CR, cerebral hypometabolism was more severe in the group of bilingual individuals with AD. The metabolic connectivity analyses crucially supported the neuroprotective effect of bilingualism by showing an increased connectivity in the executive control and the default mode networks in the bilingual, compared with the monolingual, AD patients. Furthermore, the degree of lifelong bilingualism (i.e., high, moderate, or low use) was significantly correlated to functional modulations in crucial neural networks, suggesting both neural reserve and compensatory mechanisms. These findings indicate that lifelong bilingualism acts as a powerful CR proxy in dementia and exerts neuroprotective effects against neurodegeneration. Delaying the onset of dementia is a top priority of modern societies, and the present in vivo neurobiological evidence should stimulate social programs and interventions to support bilingual or multilingual education and the maintenance of the second language among senior citizens.

Setting the Scene: The Evidence for Pre-clinical Change, Projections of the Impact of Intervention, and Implications for Public Health

2017 ◽  
Vol 41 (S1) ◽  
pp. S12-S12
Author(s):  
T.C. Russ ◽  
K. Ritchie ◽  
G.M. Terrera ◽  
C.W. Ritchie
Keyword(s):  
Public Health ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Alzheimer’S Dementia ◽  
Prevention Measures ◽  
Risk Models ◽  
Clinical Change ◽  
Alzheimer's Dementia ◽  
The Impact ◽  
Statistical Risk

Alzheimer's disease has long been considered a neurodegenerative disorder of late life for which there is currently no disease-modifying treatment. This view is now being revised as increasing evidence suggests a long pre-clinical phase extending back into mid-life during which there is exposure to multiple potentially reversible risk factors. Further thought is now being given to the possibility of both early life intervention programs and development of new drug treatments focusing on the pre-dementia period. But how can the impact of such treatments be measured at this early stage since overt dementia may not be diagnosed for decades? In the four talks in this symposium, we will discuss evidence for pre-clinical change, theoretical models which have been used to project the possible impact of risk factor modification in mid-life and their integration into a future public health strategies. The development of new statistical risk models to determine the impact of such prevention measures will be outlined. We will consider the possibilities for drug development targeting the pre-clinical period before presenting the PREVENT Project and EPAD (http://ep-ad.org/), a multi-million euro IMI-Horizon 2020 funded project for the development of pre-clinical proof of concept trials. Titles of the four presentations: 1. Setting the scene: the evidence for pre-clinical change, projections of the impact of intervention, and implications for public health (TCR) 2. New statistical risk models for determining the impact of prevention measures in the pre-dementia period (GMT) 3. The PREVENT Study: a prospective cohort study to identify mid-life biomarkers of late-onset Alzheimer's disease (KR) 4. The European Prevention of Alzheimer's Dementia (EPAD) Project: developing interventions for the secondary prevention of Alzheimer's dementia (CWR)Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals The impact of anticholinergic burden in Alzheimer's Dementia-the Laser-AD study

2011 ◽  
Vol 40 (6) ◽  
pp. 730-735 ◽  
Author(s):  
C. Fox ◽  
G. Livingston ◽  
I. D. Maidment ◽  
S. Coulton ◽  
D. G. Smithard ◽  
...  
Keyword(s):  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia ◽  
The Impact ◽  
Anticholinergic Burden

P1-306: APOE4 NON-CARRIERS WITH THE CLINICAL DIAGNOSIS OF ALZHEIMER'S DEMENTIA AND MINIMAL AMYLOID HISTOPATHOLOGY

2014 ◽  
Vol 10 ◽  
pp. P423-P423
Author(s):  
Sarah E. Monsell ◽  
Richard J. Caselli ◽  
Walter A. Kukull ◽  
Thomas G. Beach ◽  
Thomas J. Montine ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia

scholarly journals Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes

2019 ◽  
Author(s):  
Eric M. Reiman ◽  
Joseph F. Arboleda-Velasquez ◽  
Yakeel T. Quiroz ◽  
Matthew J. Huentelman ◽  
Thomas G. Beach ◽  
...  
Keyword(s):  
High Risk ◽  
Lower Risk ◽  
Alzheimer’S Dementia ◽  
Low Risk ◽  
Odds Ratios ◽  
Alzheimer's Dementia ◽  
Gene Dose ◽  
Apoe4 Allele ◽  
Treatment And Prevention ◽  
The Impact

ABSTRACTEach additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer’s dementia, such that APOE4 homozygotes have a particularly high risk. While the APOE2 allele is associated with a lower risk of Alzheimer’s dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. We generated Alzheimer’s dementia odds ratios and other findings in more than 5,000 clinically characterized and neuropathologically characterized Alzheimer’s dementia cases and controls. APOE2/2 was associated with exceptionally low Alzheimer’s dementia odds ratios compared to APOE2/3, 3/3 and 4/4, and the impact of APOE2 and APOE4 gene dose was significantly greater in the neuropathologically confirmed group than in more than 24,000 neuropathologically unconfirmed cases and controls. Finding and targeting the factors by which APOE and its variants influence Alzheimer’s disease could have a major impact on the understanding, treatment and prevention of this terrible disease.

scholarly journals Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer’s Dementia

2021 ◽  
Vol 11 ◽  
Author(s):  
Md. Sahab Uddin ◽  
Md. Motiar Rahman ◽  
Mohammad Abu Sufian ◽  
Philippe Jeandet ◽  
Ghulam Md. Ashraf ◽  
...  
Keyword(s):  
Insulin Signaling ◽  
Brain Metabolism ◽  
Alzheimer’S Dementia ◽  
Daily Activities ◽  
Alzheimer's Dementia ◽  
Impaired Insulin ◽  
Common Risk Factors ◽  
The Common ◽  
The Impact ◽  
Over Time

Alzheimer’s disease (AD) is the most common form of dementia, which causes abnormalities in learning, thinking, memory, as well as behavior. Generally, symptoms of AD develop gradually and aggravate over time, and consequently severely interfere with daily activities. Furthermore, obesity is one of the common risk factors for dementia. Dysregulation of adipokine and adipocyte dysfunction are assumed to be accountable for the high risk of obesity in people that develop many related disorders such as AD. Moreover, it has been observed that the dysfunction of adipose is connected with changes in brain metabolism, brain atrophy, cognitive decline, impaired mood, neuroinflammation, impaired insulin signaling, and neuronal dysfunction in people with obesity. Conversely, the pathological mechanisms, as well as the molecular players which are involved in this association, have been unclear until now. In this article, we discuss the impact of adiponectin (AdipoQ) on obesity-related Alzheimer’s dementia.

Executive Dysfunctions Predict Self-Restricted Driving Habits in Elderly People with or without Alzheimer’s Dementia

2017 ◽  
Vol 50 (05) ◽  
pp. 203-210 ◽  
Author(s):  
Ilsemarie Kurzthaler ◽  
Georg Kemmler ◽  
Michaela Defrancesco ◽  
Bernadette Moser ◽  
Wolfgang Fleischhacker ◽  
...  
Keyword(s):  
Executive Functions ◽  
Alzheimer’S Dementia ◽  
Entire Group ◽  
Alzheimer's Dementia ◽  
Elderly Drivers ◽  
Healthy Elderly ◽  
Ordinal Regression Analysis ◽  
Study Population ◽  
The Impact ◽  
Executive Dysfunctions

Abstract Introduction The purpose of this study was to elucidate the impact of specific cognitive functions on self-restricted driving habits in healthy elderly drivers and patients suffering from mild cognitive impairment (MCI) and Alzheimer’s dementia (AD). Method Our study population included 35 cognitively healthy controls, 10 MCI patients, and 16 patients with AD. All participants completed a neuropsychological examination and a self-reported questionnaire assessing driving habits and patterns. Results In challenging driving conditions, patients with MCI or AD showed significantly more driving self-restriction than healthy subjects (effect size d=1.06, p=0.007). Ordinal regression analysis across the entire group revealed that deficits in executive functions and reaction had a higher impact on driving restriction (p=0.002) than deficits in memory functions (p=0.570). Additionally, our data showed that 40% of patients with mild to moderate AD still drive in challenging conditions. Discussion Our results illustrate that elderly individuals use self-imposed driving restrictions as compensatory strategies. These restrictions increase with cognitive decline mainly in the field of executive functions, but they do not change once patients convert from MCI to AD.

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