P3-156: Screening question on spatial navigation reflects performance in the real-space human analogue of the Morris Water Maze in people at risk of Alzheimer's disease

2013 ◽  
Vol 9 ◽  
pp. P610-P611
Author(s):  
Ivana Mokrišová ◽  
Jan Laczó ◽  
Ross Andel ◽  
Martin Vyhnalek ◽  
Ivana Gazova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Morris Water Maze ◽  
Water Maze ◽  
Spatial Navigation ◽  
Real Space ◽  
The Real ◽  
Screening Question

Human Analogue of the Morris Water Maze for Testing Subjects at Risk of Alzheimer’s Disease

2010 ◽  
Vol 7 (1-3) ◽  
pp. 148-152 ◽  
Author(s):  
J. Laczó ◽  
R. Andel ◽  
M. Vyhnalek ◽  
K. Vlcek ◽  
H. Magerova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Morris Water Maze ◽  
Water Maze

scholarly journals Musical Electroacupuncture May Be a Better Choice than Electroacupuncture in a Mouse Model of Alzheimer’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Jing Jiang ◽  
Gang Liu ◽  
Suhua Shi ◽  
Zhigang Li
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Frontal Lobe ◽  
Morris Water Maze ◽  
Water Maze ◽  
Morris Water Maze Test ◽  
Maze Test ◽  
Model Of Alzheimer’S Disease ◽  
Samp8 Mice

Objectives. To compare musical electroacupuncture and electroacupuncture in a mouse model of Alzheimer’s disease.Methods. In this study, 7.5-month-old male senescence-accelerated mouse prone 8 (SAMP8) mice were used as an Alzheimer’s disease animal model. In the normal control paradigm, 7.5-month-old male SAMR1 mice were used as the blank control group (N group). After 15 days of treatment, using Morris water maze test, micro-PET, and immunohistochemistry, the differences among the musical electroacupuncture (MEA), electroacupuncture (EA), Alzheimer’s disease (AD), and normal (N) groups were assessed.Results. The Morris water maze test, micro-PET, and immunohistochemistry revealed that MEA and EA therapies could improve spatial learning and memory ability, glucose metabolism level in the brain, and Aβamyloid content in the frontal lobe, compared with the AD group (P<0.05). Moreover, MEA therapy performed better than EA treatment in decreasing amyloid-beta levels in the frontal lobe of mice with AD.Conclusion. MEA therapy may be superior to EA in treating Alzheimer’s disease as demonstrated in SAMP8 mice.

EFRH–Phage Immunization of Alzheimer's Disease Animal Model Improves Behavioral Performance in Morris Water Maze Trials

2004 ◽  
Vol 24 (1) ◽  
pp. 105-114 ◽  
Author(s):  
Vered Lavie ◽  
Maria Becker ◽  
Rachel Cohen-Kupiec ◽  
Iftach Yacoby ◽  
Rela Koppel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Model ◽  
Morris Water Maze ◽  
Water Maze ◽  
Behavioral Performance

scholarly journals Unraveling Early Signs of Navigational Impairment in APPswe/PS1dE9 Mice Using Morris Water Maze

2020 ◽  
Vol 14 ◽  
Author(s):  
Smitha Karunakaran
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Morris Water Maze ◽  
Water Maze ◽  
Maze Learning ◽  
Wild Type ◽  
Behavioral Deficits ◽  
Model Of Alzheimer’S Disease ◽  
Error Learning ◽  
Early Indicators

Mild behavioral deficits, which are part of normal aging, can be early indicators of an impending Alzheimer's disease. Using the APPswe/PS1dE9 (APP/PS1) mouse model of Alzheimer's disease, we utilized the Morris water maze spatial learning paradigm to systematically evaluate mild behavioral deficits that occur during the early stages of disease pathogenesis. Conventional behavioral analysis using this model indicates that spatial memory is intact at 2 months of age. In this study, we used an alternative method to analyze the behavior of mice, aiming to gain a better understanding of the nature of cognitive deficits by focusing on the unsuccessful trials during water maze learning rather than on the successful ones. APP/PS1 mice displayed a higher number of unsuccessful trials during the initial days of training, unlike their wild-type counterparts. However, with repeated trial and error, learning in APP/PS1 reached levels comparable to that of the wild-type mice during the later days of training. Individual APP/PS1 mice preferred a non-cognitive search strategy called circling, which led to abrupt learning transitions and an increased number of unsuccessful trials. These findings indicate the significance of subtle intermediate readouts as early indicators of conditions such as Alzheimer's disease.

scholarly journals Test-retest reliability of spatial navigation in adults at-risk of Alzheimer’s disease

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0239077
Author(s):  
Gillian Coughlan ◽  
Vaisakh Puthusseryppady ◽  
Ellen Lowry ◽  
Rachel Gillings ◽  
Hugo Spiers ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Spatial Navigation ◽  
Retest Reliability ◽  
Test Retest Reliability
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