P3-229: Cognitive difficulties as a patient-reported outcome for older adults with normal cognition, MCI or mild Alzheimer's disease

2013 ◽  
Vol 9 ◽  
pp. P639-P639
Author(s):  
Jason Karlawish ◽  
Elizabeth Sullo ◽  
Jonathan D. Rubright ◽  
Stephanie Cosentino ◽  
Mark Cary
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Patient Reported Outcome ◽  
Cognitive Difficulties ◽  
Patient Reported ◽  
Normal Cognition

scholarly journals Cognitive Health in Massachusetts, New Hampshire, and Rhode Island: Findings From the Healthy Aging Data Reports

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 93-93
Author(s):  
Richard Chunga ◽  
Taylor Jansen ◽  
Chae Man Lee ◽  
Shuangshuang Wang ◽  
Haowei Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
New England ◽  
Rhode Island ◽  
Healthy Aging ◽  
Living Alone ◽  
Policy And Practice ◽  
Cognitive Difficulties ◽  
Cognitive Difficulty

Abstract Over time persons with Alzheimer’s disease (AD) have impaired health, lower quality of life, and increased mortality compared to those without AD. This study describes state and community rates of Alzheimer’s disease, self-rated cognitive difficulty, and the % of the population age 85+ in three New England states (MA, NH, RI). Data sources were the American Community Survey (2009-2013 RI, 2012-2016 MA/NH) and the CMS Medicare Current Beneficiary Summary File (2012-2013 RI, 2015 MA/NH). Small area estimation techniques were used to calculate age-sex adjusted community rates for Alzheimer’s disease and related dementias (ADRD), self-reported cognitive difficulties, percentage of older adults 85 years or older, and the percentage of adults age 65+ living alone. State rates (range) were: AD: RI 14.4% (8-23%), MA 13.6% (6-19.31%), and NH 12% (5.49-33.51%). Self-reported cognitive difficulty: MA 8.3% (0-25.16%), RI 7.8% (2-18%), and NH were 6.9% (0-34.21%). Adults 85 years and older: RI 17.6% (6-24%), MA 15.2% (0-32.23%), and NH 12.9% (0-27.91%). Living alone: RI 30.4% (12-45%), MA 30.2% (6.25-50%), and NH 26.1% (6.13-72.55%). While there was significant variation across states, Rhode Island had the highest state rate of ADRD, older adults 85 and older, and percentage of older adults living alone. Within-state disparities among AD rates, cognitive difficulties, and living alone was highest in NH, but MA had the largest variation for community rates of adults 85+. Understanding the prevalence of brain health is important to policy and practice efforts to promote age-friendly communities. This research was supported by the Tufts Health Plan Foundation.

scholarly journals AFFECTIVE NEUROPSYCHIATRIC SYMPTOMS MAY BE EARLY SIGNS OF ALZHEIMER'S DISEASE IN NON-DEMENTED OLDER ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S971-S971
Author(s):  
Jung Y Jang ◽  
Daniel A Nation
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Latent Class ◽  
Neuropsychiatric Symptoms ◽  
Csf Biomarkers ◽  
Carrier Status ◽  
Risk Of Progression ◽  
The Brain ◽  
Normal Cognition

Abstract The current study sought to investigate the association between affective neuropsychiatric symptoms (aNPS: depression, anxiety, apathy, irritability), Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers profiles, and the risk of progression to dementia in non-demented older adults. Participants consisted of 763 individuals with normal cognition (CN) (mean age = 73.73 ± 6.68) and 617 with mild cognitive impairment (MCI) (mean age = 73.19 ± 7.40) at baseline, who were enrolled in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Latent class analyses (LCA) identified three subgroups of older adults within CN and MCI, respectively, showing distinct patterns of the neuropsychiatric inventory (NPI) domains. Results indicated that the subgroup with higher probabilities of aNPS had elevated risk of progression to dementia (HR = 3.18, 95% CI [1.70, 5.94] in CN, HR = 1.79, 95% CI [1.01, 3.16] in MCI), adjusting for age, sex, and Apolipoprotein E e4 (APOE4) carrier status. Subgroups did not differ in their profiles of AD CSF biomarkers. Findings suggest that aNPS might be symptoms of secondary disease processes in the brain, lowering the threshold for AD pathophysiology to manifest clinically in CN and MCI. The current study highlights the importance of assessment and interventions for emotional and behavioral symptoms in non-demented older adults.

Cognitive control constrains memory attributions

2019 ◽  
Vol 42 ◽  
Author(s):  
Colleen M. Kelley ◽  
Larry L. Jacoby
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

Partner-Specific Communication Deficits in Individuals With Alzheimer's Disease

2020 ◽  
pp. 1-15
Author(s):  
Eun Jin Paek ◽  
Si On Yoon
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Referential Communication ◽  
Sorting Task ◽  
Audience Design ◽  
Healthy Older Adults ◽  
Communication Task ◽  
Design Skills ◽  
Referential Expressions

Purpose Speakers adjust referential expressions to the listeners' knowledge while communicating, a phenomenon called “audience design.” While individuals with Alzheimer's disease (AD) show difficulties in discourse production, it is unclear whether they exhibit preserved partner-specific audience design. The current study examined if individuals with AD demonstrate partner-specific audience design skills. Method Ten adults with mild-to-moderate AD and 12 healthy older adults performed a referential communication task with two experimenters (E1 and E2). At first, E1 and participants completed an image-sorting task, allowing them to establish shared labels. Then, during testing, both experimenters were present in the room, and participants described images to either E1 or E2 (randomly alternating). Analyses focused on the number of words participants used to describe each image and whether they reused shared labels. Results During testing, participants in both groups produced shorter descriptions when describing familiar images versus new images, demonstrating their ability to learn novel knowledge. When they described familiar images, healthy older adults modified their expressions depending on the current partner's knowledge, producing shorter expressions and more established labels for the knowledgeable partner (E1) versus the naïve partner (E2), but individuals with AD were less likely to do so. Conclusions The current study revealed that both individuals with AD and the control participants were able to acquire novel knowledge, but individuals with AD tended not to flexibly adjust expressions depending on the partner's knowledge state. Conversational inefficiency and difficulties observed in AD may, in part, stem from disrupted audience design skills.

Auditory Dysfunction in Alzheimer's Disease

2010 ◽  
Vol 15 (1) ◽  
pp. 4-11 ◽  
Author(s):  
Sridhar Krishnamurti
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Health Care ◽  
Care Setting ◽  
Neurodegenerative Disorder ◽  
Disease Process ◽  
Clinical Protocols ◽  
Speech Language Pathologist ◽  
Auditory Dysfunction

Alzheimer's disease is neurodegenerative disorder which affects a growing number of older adults every year. With an understanding of auditory dysfunction in Alzheimer's disease, the speech-language pathologist working in the health care setting can provide better service to these individuals. The pathophysiology of the disease process in Alzheimer's disease increases the likelihood of specific types of auditory deficits as opposed to others. This article will discuss the auditory deficits in Alzheimer's disease, their implications, and the value of clinical protocols for individuals with this disease.

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