COLOR VISION IMPAIRMENT IN DEMENTIA WITH LEWY BODIES: A NOVEL AND HIGHLY SPECIFIC DISTINGUISHING FEATURE FROM ALZHEIMER DEMENTIA

2017 ◽  
Vol 13 (7) ◽  
pp. P1460 ◽  
Author(s):  
Patrick M. Flanigan ◽  
Mitra A. Khosravi ◽  
James B. Leverenz ◽  
Babak Tousi
2018 ◽  
Vol 31 (2) ◽  
pp. 97-102 ◽  
Author(s):  
Patrick M. Flanigan ◽  
Mitra A. Khosravi ◽  
James B. Leverenz ◽  
Babak Tousi

Objective: Dementia with Lewy bodies (DLB) is frequently misdiagnosed for Alzheimer dementia (AD), especially in its earlier stages. We characterized color vision impairment (CVI) in patients with DLB versus patients with AD to determine its usefulness in improving accuracy of early diagnosis. Methods: We retrospectively reviewed charts of patients with AD, DLB, and patients with mild cognitive impairment suspected to be in the prodromal phase of DLB (pro-DLB) or prodromal phase of AD (pro-AD). All patients underwent an online 15-hue color vision arrangement test. Results: Fifty-two patients were included in this study with a median age of 77 years, of which 44% were female. No significant differences in gender, age, or Montreal Cognitive Assessment existed among patients with AD (n = 15), pro-AD (n = 5), pro-DLB (n = 8), and DLB (n = 24). Of the 52 patients, 4 (2 AD, 1 DLB, and 1 pro-AD) had CVI history from a young age and were excluded from final analyses. New-onset CVI prevalence differed significantly based on diagnosis: patients with pro-AD (20%), patients with AD (15%), patients with pro-DLB (38%), and patients with DLB (78%, P < .001). In a stepwise multivariate logistic regression analysis to determine factors associated with CVI, “diagnosis type” as a binary variable (DLB or pro-DLB vs AD or pro-AD) was the only variable retained in the model (odds ratio = 9.8 [95% CI: 2.3-42.1], P < .001). Conclusions: Color vision impairment in patients with DLB showed a prevalence similar to the core features of DLB (∼80%) and can be supportive to a diagnosis of DLB versus AD. Pending prospective confirmation of our findings, simple online color vision testing could be incorporated into multivariate diagnostic tools to possibly improve accuracy of early diagnosis of DLB.


2006 ◽  
Vol 14 (7S_Part_15) ◽  
pp. P800-P801
Author(s):  
Patrick M. Flanigan ◽  
Mitra A. Khosravi ◽  
Babak Tousi

2018 ◽  
Vol 66 ◽  
pp. 179-184 ◽  
Author(s):  
Claudia Feitosa-Santana ◽  
Givago da Silva Souza ◽  
Esaú Ventura Pupo Sirius ◽  
Anderson Raiol Rodrigues ◽  
Maria Izabel Tentes Cortes ◽  
...  

2008 ◽  
Vol 83 (1) ◽  
pp. 148-149
Author(s):  
Marcelo Fernandes Costa ◽  
Andre Gustavo Fernandes Oliveira ◽  
Claudia Feitosa-Santana ◽  
Mayana Zatz ◽  
Dora Fix Ventura

2018 ◽  
Vol 32 (6) ◽  
pp. 601-606
Author(s):  
Sonia Wagner ◽  
Miguel Rioseco ◽  
Duniel Ortuño ◽  
María F. Cortés ◽  
Carolina Costa

2019 ◽  
Vol 90 (e7) ◽  
pp. A19.3-A20
Author(s):  
Elie Matar ◽  
Joseph R Phillips ◽  
Kaylena A Ehgoetz Martens ◽  
Glenda M Halliday ◽  
Simon JG Lewis

IntroductionEmerging evidence indicates that color discrimination impairments can predict the development of dementia across a range of prodromal Lewy body conditions. However, color vision deficits are not seen uniformly in patients with Dementia with Lewy Bodies (DLB), suggesting a more nuanced association. Visual hallucinations(VH) represent a discriminating feature of DLB, and recent evidence implicates visual pathway dysfunction as a significant contributor to this phenomenon. We therefore hypothesized that color impairment will more closely associate with VH in DLB rather than general cognition.MethodsIn this study, we examined the relationship between color vision impairment and VH, along with other clinical and neuropsychological features in 24 patients with DLB alongside 25 age-matched controls. Color discrimination was assessed using the Farnsworth-Munsell-100 Hue (FM-100) test.ResultsColor discrimination impairment was seen in 16/24 DLB participants (67%) with a higher error score relative to controls(p=0.001). We demonstrate for the first time a strong association between color discrimination errors and both the presence and severity of VH in DLB based on clinician-derived(p=0.008) and questionnaire-derived(p=0.03) measures. Correlation with clinical and neuropsychological variables revealed that color discrimination is significantly related to visuospatial impairment(p=0.02) but not to global measures of cognition, motor severity, age or disease duration. Factor analysis confirmed a unique relationship between color discrimination, visual hallucinations and visuospatial function.ConclusionOur results suggest that color impairments may be a specific biomarker of visual hallucinations and associated visuoperceptual deficits in evolving Lewy body disorders rather than dementia per se and thus providing insight into a shared pathophysiological substrate.


2015 ◽  
Vol 262 (11) ◽  
pp. 2491-2497 ◽  
Author(s):  
E. J. Lampert ◽  
M. Andorra ◽  
R. Torres-Torres ◽  
S. Ortiz-Pérez ◽  
S. Llufriu ◽  
...  

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