P2-067: WHAT WOULD BE THE LIKELY IMPACT OF AN INTERVENTION THAT SUCCESSFULLY PREVENTED NEOCORTICAL ACCUMULATION OF NEURITIC AMYLOID PLAQUES AND A HIGH BRAAK STAGE? THOUGHT EXPERIMENTS USING DATA FROM THE NUN STUDY (NS) AND THE HONOLULU-ASIA AGING STUDY

2006 ◽  
Vol 14 (7S_Part_12) ◽  
pp. P692-P692
Author(s):  
Lon R. White ◽  
Steven D. Edland ◽  
Laura S. Hemmy ◽  
Margaret E. Flanagan ◽  
Catherine Liu ◽  
...  
Keyword(s):  
Thought Experiments ◽  
Amyloid Plaques ◽  
Braak Stage ◽  
Aging Study ◽  
Using Data ◽  
Nun Study

scholarly journals USING MOBILE TECHNOLOGY TO ELUCIDATE PSYCHOSOCIAL AND COGNITIVE FUNCTION IN OLDER ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S809-S810
Author(s):  
Nelson A Roque ◽  
Jinshil Hyun ◽  
Stacey B Scott
Keyword(s):  
Older Adults ◽  
Cognitive Aging ◽  
Ecological Validity ◽  
Risk Groups ◽  
Cognitive Status ◽  
Cognitive Assessments ◽  
Longitudinal Data Collection ◽  
Aging Study ◽  
Physical Touch ◽  
Using Data

Abstract Ambulatory methods (AM) improve the reliability and ecological validity of cognitive assessments, and help to elucidate psychological influences through concurrent reports of pain, stress, and other psychosocial outcomes. Ecological momentary assessment (EMA) involves sampling of daily experiences in natural settings, including completing cognitive assessments, and answering questions related to, for example, social interactions and sleep. The purpose of this symposium is to present innovative methods and results, exploring questions at the intersection of intensive longitudinal data collection, cognition, and psychosocial influences, using data from two EMA studies, the Einstein Aging Study (EAS) and the Effects of Stress on Cognitive Aging, Physiology, and Emotion (ESCAPE) Study. The EAS (ages >= 70) and ESCAPE (ages 25 - 65) protocols, ask participants to complete an annual 14-day EMA measurement burst. A unique value of these methods is the ability to explore effects from moment-to-moment (or day-to-day; within-person effects) as we will present. We will also contrast these with conventional analyses of between-person differences, typical of clinic and in-person studies. Dickens (using ESCAPE data) examines end-of-day perceived stress and anticipation of next-day stress in predicting sleep quality. Hyun and colleagues (using EAS data) discuss the effects of affectionate physical touch on mitigating pain and emotional distress. Using a model-based cluster analysis approach (with EAS data), Roque unpacks differences in psychosocial factors, as a function of cognitive status risk groups. Stacey Scott will discuss these papers in the context of using ambulatory methods to improve the characterization of risk status in older adults.

scholarly journals O2-05-05: Factors associated with cognitive impairment in persons with autopsy Braak stage 4 or greater: Results from the Honolulu-Asia Aging Study (HAAS)

2010 ◽  
Vol 6 ◽  
pp. S108-S108
Author(s):  
Lon White ◽  
Helen Petrovitch ◽  
Webster Ross ◽  
Kamal Masaki ◽  
Jane Uyehara-Lock ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Braak Stage ◽  
Factors Associated ◽  
Stage 4 ◽  
Aging Study

scholarly journals Land Use Mix and Physical Activity in Older Adults: A Longitudinal Study Examining Changes in Land Use Mix in Two Dutch Cohorts

2020 ◽  
Author(s):  
J. Mark Noordzij ◽  
M.A. Beenackers ◽  
J. Oude Groeniger ◽  
E.J. Timmermans ◽  
I. Motoc ◽  
...  
Keyword(s):  
Land Use ◽  
Sensitivity Analyses ◽  
Buffer Size ◽  
Land Use Mix ◽  
Aging Populations ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study ◽  
Using Data

Abstract BACKGROUNDWith urbanization and aging increasing in coming decades, societies face the challenge of keeping aging populations active. Land use mix (LUM) has been associated with cycling and walking, but whether changes in LUM relate to changes in cycling/walking is less known. OBJECTIVESOur objective was to study the effect of LUM on cycling/walking in two Dutch aging cohorts using data with 10 years of follow-up. METHODSData from 1,114 respondents from the Longitudinal Aging Study Amsterdam (LASA) and 1,561 respondents from the Health and Living Conditions of the Population of Eindhoven and Surroundings (GLOBE) study were linked to LUM in 1000-meter sausage network buffers at three time-points. Cycling/walking outcomes were harmonized to include average minutes spent cycling/walking per week. Data was pooled and limited to respondents that did not relocate between follow-up waves. Associations between LUM and cycling/walking were estimated using a Random Effects Within-Between (REWB) model that allows for the estimation of both within and between effects. Sensitivity analyses were performed on smaller (500-meter) and larger (1600-meter) buffers. RESULTSWe found evidence of between-individual associations of LUM in 1000-meter buffers and walking (β: 11.10, 95% CI: 0.08 ; 21.12), but no evidence of within-associations in 1000-meter buffers. Sensitivity analyses using 500-meter buffers showed similar between-associations, but negative within-associations (β: -35.67, 95% CI: -68.85 ; -2.49). We did not find evidence of between-individual associations of LUM in any buffer size and cycling, but did find evidence of negative within-associations between LUM in 1600-meter buffers and cycling (β: -7.49, 95% CI: -14.31 ; -0.66). DISCUSSIONOur study found evidence of positive associations between LUM and average walking time, but also some evidence of negative associations between a change in LUM and cycling/walking. LUM appears to be related to cycling/walking, but the effect of changes in LUM on cycling/walking is unclear.

Relations Between Health-Related Quality of Life and Well-Being: The Gerontologist's New Clothes?

2000 ◽  
Vol 50 (4) ◽  
pp. 297-318 ◽  
Author(s):  
Avron Spiro ◽  
Raymond Bossé
Keyword(s):  
Quality Of Life ◽  
Life Satisfaction ◽  
Well Being ◽  
Health Related Quality ◽  
Moderate Amount ◽  
Aging Study ◽  
Related Quality ◽  
Health Related ◽  
Using Data

Is the recent construct of health-related quality of life (HQL) distinct from what gerontologists have long referred to as “well-being” or “life satisfaction?” We addressed this question using data from men in the VA Normative Aging Study to examine relations among twelve scales assessing HQL and seven scales of well-being (WB). We hypothesized that these two constructs would be distinct factorially, and that the derived factors would have different correlates. Correlations between scales of HQL and WB were moderate. When the nineteen scales were factored, four factors were extracted with HQL and WB scales generally loading on separate factors. The factors had distinct patterns of relations with general quality of life, personality, and the presence of a health problem, controlling for sociodemographics. These results suggest that HQL is distinct from the older construct of well-being. Although the two constructs are conceptually related, there is only a moderate amount of statistical overlap between them. Gerontologists should readily adopt health-related quality of life, which maintains continuity with such classics as well-being. This new construct, although needing slight alterations to broaden its assessment of well-being and life satisfaction, holds promise as more than an accessory in the study of health and well-being among older persons.

scholarly journals The harmonisation of longitudinal data: a case study using data from cohort studies in The Netherlands and the United Kingdom

2010 ◽  
Vol 30 (8) ◽  
pp. 1419-1437 ◽  
Author(s):  
PETER A. BATH ◽  
DORLY DEEG ◽  
JAN POPPELAARS
Keyword(s):  
United Kingdom ◽  
The Netherlands ◽  
Religious Attendance ◽  
Measurement Instruments ◽  
Data Set ◽  
The United Kingdom ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Using Data

ABSTRACTThis paper presents a case study of the challenges and requirements associated with harmonising data from two independently-conceived datasets from The Netherlands and the United Kingdom: the Longitudinal Aging Study Amsterdam (LASA) and the Nottingham Longitudinal Study of Activity and Ageing (NLSAA). The objectives were to create equivalent samples and variables, and to identify the methodological differences that affect the comparability of the samples. Data are available from the two studies' 1992–93 surveys for respondents born during 1908–20, and the common data set had 1,768 records and enabled the creation of 26 harmonised variables in the following domains: demographic composition and personal finances, physical health, mental health and loneliness, contacts with health services, physical activity, religious attendance and pet ownership. The ways in which the methodological differences between the two studies and their different selective attrition might lead to sample differences were carefully considered. It was concluded that the challenges of conducting cross-national comparative research using independent datasets include differences in sampling, study design, measurement instruments, response rates and selective attrition. To reach conclusions from any comparative study about substantive socio-cultural differences, these challenges must first be identified and addressed.

scholarly journals Vision and Cognition: Findings from the Longitudinal Aging Study in India—Diagnostic Assessment of Dementia

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 660-660
Author(s):  
Joshua Ehrlich ◽  
Sandy Chien ◽  
Jinkook Lee
Keyword(s):  
Cognitive Decline ◽  
Cognitive Aging ◽  
Linear Models ◽  
Diagnostic Assessment ◽  
Cognitive Measures ◽  
Poor Vision ◽  
Cognitive Domains ◽  
Aging Study ◽  
Longitudinal Aging Study ◽  
Using Data

Abstract Vision impairment (VI) is associated with cognitive decline and dementia, however little research has been conducted in India. Using data from LASI-DAD, linear models tested the association of VI (better-seeing eye <20/60) with cognitive domains including orientation, learning/memory, language, attention, and total cognition. Models were adjusted for age, sex, geographic, and socioeconomic characteristics. VI was significantly associated with lower orientation (β=-0.47, p<.01), learning/memory (β=-4.6, p<.01), attention (β=-1.6, p<.01), and total cognition (β=-8.4, p<.01), but not language (β=-0.14, p<.1) scores. The association of VI with cognitive measures did not vary by sex. For each measure, VI was equivalent to 5-13 years of cognitive aging. In summary, VI is associated with poorer performance in most cognitive domains among older Indian adults. Longitudinal data are needed to determine directionality and causality. Since >80% of VI in India is treatable, poor vision may represent a modifiable risk factor for cognitive decline and dementia.

scholarly journals Comprehensive Profiling of Plasma Exosomes Using Data-Independent Acquisitions – New Tools for Aging Cohort Studies

2021 ◽  
Author(s):  
Sandip K. Patel ◽  
Roland Bruderer ◽  
Nathan Basisty ◽  
Joanna Bons ◽  
Pierre-Yves Desprez ◽  
...  
Keyword(s):  
Reversed Phase ◽  
The Body ◽  
Size Exclusion ◽  
Biomarkers Of Aging ◽  
Age Related ◽  
Complex Biological Process ◽  
High Throughput Method ◽  
Aging Study ◽  
Exclusion Chromatography ◽  
Using Data

AbstractAging is a complex biological process associated with progressive loss of physiological function and susceptibility to several diseases, such as cancer and neurodegeneration. Exosomes are involved in many cellular signaling pathways, and their cargo may serve as promising disease or aging biomarkers. These membrane-bound extracellular vesicles facilitate the transport of intracellular contents to proximal and distal cells in the body. Here, we investigated two omics approaches for exosome analysis. To overcome the challenges of plasma exosome contamination with abundant soluble plasma proteins, we developed a high-throughput method to isolate highly purified exosomes from human plasma by sequential size-exclusion chromatography and ultrafiltration. First, we used data-dependent acquisitions from offline high-pH reversed-phase fractions of exosome lysate to generate a deep spectral library comprising ∼2,300 exosome proteins. Second, in a pilot aging study, we used comprehensive data-independent acquisitions to compare plasma exosomes from young (20–26 yrs) and old (60–66 yrs) individuals. We quantified 1,318 exosome proteins, and levels of 144 proteins were significantly different in young and old plasma groups (Q<0.05 and >1.5-fold change). We also analyzed exosome miRNA cargo and detected 331 miRNAs. Levels of several were significantly different in young and old individuals. In addition, 88 and 17 miRNAs were unique to old and young individuals, respectively. Plasma exosome biomarkers have great potential for translational studies investigating biomarkers of aging and age-related diseases and to monitor therapeutic aging interventions.

scholarly journals TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study

2018 ◽  
Vol 66 (4) ◽  
pp. 1549-1558 ◽  
Author(s):  
Margaret E. Flanagan ◽  
Brenna Cholerton ◽  
Caitlin S. Latimer ◽  
Laura S. Hemmy ◽  
Steven D. Edland ◽  
...  
Keyword(s):  
Aging Study ◽  
Nun Study

scholarly journals Expansion of disability across successive Mexican birth cohorts: a longitudinal modelling analysis of birth cohorts born 10 years apart

2019 ◽  
Vol 73 (10) ◽  
pp. 900-905 ◽  
Author(s):  
Collin F Payne ◽  
Rebeca Wong
Keyword(s):  
Daily Living ◽  
Adult Health ◽  
Birth Cohorts ◽  
Middle Income ◽  
Item Questionnaire ◽  
Modelling Analysis ◽  
Aging Study ◽  
Physical Limitations ◽  
Mexican Adults ◽  
Using Data

BackgroundLife expectancy (LE) in Mexico has risen rapidly since the 1950s. In high-income contexts, these increases have coincided with a compression of disability to later ages. However, little evidence on trends in disability-free LE (DFLE) exist from Mexico or elsewhere in Latin America.MethodsUsing data from the Mexican Health and Aging Study, we compare changes in LE and DFLE in ages 50–59, 60–69 and 70–79 using birth-cohort-specific multistate lifetable models across successive 10-year birth cohorts. Disability was measured using the Katz activities of daily living (ADL) index, and limitation was measured using a seven-item questionnaire on physical functioning.ResultsOverall, Mexican adults born in 1953–1962 lived 0.87 (p<0.001) fewer active years between ages 50 and 59 than individuals born in 1942–1951, a difference comprised of a 0.54-year (p<0.001) increase in physically limited LE and a 0.27-year (p<0.001) increase in ADL-disabled LE. Active LE declined by 1.13 (p<0.001) years in ages 60–69, and by 0.93 (p<0.001) years in ages 70–79, across successive 10-year birth cohorts. No substantial changes in total LE were seen in any age group, and the magnitude of the expansion of disability was larger in females than in males.ConclusionsOur results indicate that more recently born cohorts of Mexican adults are spending more years of life with physical limitations and disabilities. These results foreshadow a need to closely monitor adult health in middle-income contexts, as the epidemiological conditions under which disability has expanded in Mexico are similar to those seen in many other countries.

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