Risk Factors Associated with Primary Liver Cancer in Severely Obese Subjects and the Impact of Metabolic Surgery as a Measure of Primary Prevention: A Nationwide Case-Control Analysis

7068 Background: Bevacizumab (BV) added to chemotherapy prolongs survival in non-squamous NSCLC, but was uncommonly associated with serious pulmonary hemorrhage (PH) (Sandler A, et al, ASCO 2005). A retrospective study was conducted to potentially identify clinical or radiographic (CT) risk factors associated with early onset (<150 days from initial treatment) PH. Methods: A broad search of the E4599 database for selected bleeding terms among BV-treated patients was conducted. Cases of PH were identified and adjudicated. Associations between baseline clinical factors and incidence of PH were evaluated in the full cohort of E4599 patients. In addition, a separate case-control analysis, using controls matched on age and sex, was conducted to evaluate baseline CT variables. Chest CTs were evaluated by blinded independent assessment of lesion location, cavitation, size of largest tumor or nodal mass, vascular involvement, presence of an endobronchial tumor, and total number of intra-thoracic lesions. Additional analyses were also conducted including cases of late-onset PH, post-baseline variables such as unconfirmed tumor response at 6 weeks (RECIST) and cavitation, and combined CT data from E4599 and an earlier Ph II trial. Results: Of 425 BV-treated pts, 10 cases of PH were identified. Of these, 7 were PH without additional complicating factors, and 6 were of early-onset. The cohort analysis of these 6 early-onset cases is presented ( table ). The case-control analysis on CT risk factors is ongoing. Conclusion: PH was an uncommon event, and based on this, no evidence was observed for an association between the baseline clinical variables and the incidence of early-onset events of PH without additional complicating factors. Conclusions for the CT variables evaluated will be presented. [Table: see text] [Table: see text]

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Rapid Weight Loss after Metabolic Surgery Decreases Hospitalizations for Systolic Heart Failure in High Risk Severely Obese Subjects. Case Control Analysis of the U.S. National Inpatient Sample (NIS) Database

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2021.08.024 ◽

2021 ◽

Vol 233 (5) ◽

pp. e8

Author(s):

David Romero Funes ◽

David Gutierrez ◽

Lisandro Montorfano ◽

Emanuele Lo Menzo ◽

Samuel Szomstein ◽

...

Keyword(s):

Heart Failure ◽

Systolic Heart Failure ◽

Case Control ◽

Control Analysis ◽

Rapid Weight Loss ◽

National Inpatient Sample ◽

Severely Obese ◽

Obese Subjects ◽

Case Control Analysis ◽

The U.S

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Epidemiology and factors associated with candidaemia following Clostridium difficile infection in adults within metropolitan Atlanta, 2009–2013

Epidemiology and Infection ◽

10.1017/s0950268815003027 ◽

2015 ◽

Vol 144 (7) ◽

pp. 1440-1444 ◽

Cited By ~ 7

Author(s):

S. VALLABHANENI ◽

O. ALMENDARES ◽

M. M. FARLEY ◽

J. RENO ◽

Z. T. SMITH ◽

...

Keyword(s):

Risk Factors ◽

Clostridium Difficile ◽

Clostridium Difficile Infection ◽

Population Based ◽

Case Control ◽

Control Analysis ◽

Factors Associated ◽

Matched Case ◽

Case Control Analysis

SUMMARYWe assessed prevalence of and risk factors for candidaemia following Clostridium difficile infection (CDI) using longitudinal population-based surveillance. Of 13 615 adults with CDI, 113 (0·8%) developed candidaemia in the 120 days following CDI. In a matched case-control analysis, severe CDI and CDI treatment with vancomycin + metronidazole were associated with development of candidaemia following CDI.

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A case control analysis investigating risk factors and outcomes for nephrocalcinosis and renal calculi in neonates

Journal of Pediatric Urology ◽

10.1016/j.jpurol.2017.06.018 ◽

2017 ◽

Vol 13 (4) ◽

pp. 356.e1-356.e5 ◽

Cited By ~ 3

Author(s):

Melissa Huynh ◽

Roderick Clark ◽

Jenny Li ◽

Guido Filler ◽

Sumit Dave

Keyword(s):

Risk Factors ◽

Renal Calculi ◽

Case Control ◽

Control Analysis ◽

Case Control Analysis

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Prevalence and Risk Factors Associated with Vancomycin-Resistant Staphylococcus aureus Precursor Organism Colonization among Patients with Chronic Lower-Extremity Wounds in Southeastern Michigan

Infection Control and Hospital Epidemiology ◽

10.1086/671735 ◽

2013 ◽

Vol 34 (9) ◽

pp. 954-960 ◽

Cited By ~ 13

Author(s):

Pritish K. Tosh ◽

Simon Agolory ◽

Bethany L. Strong ◽

Kerrie VerLee ◽

Jennie Finks ◽

...

Keyword(s):

Risk Factors ◽

Staphylococcus Aureus ◽

Lower Extremity ◽

Chronic Wounds ◽

Cohort Analysis ◽

Case Control ◽

Control Analysis ◽

Vancomycin Resistant ◽

Clinical Records ◽

Case Control Analysis

Background.Of the 13 US vancomycin-resistant Staphylococcus aureus (VRSA) cases, 8 were identified in southeastern Michigan, primarily in patients with chronic lower-extremity wounds. VRSA infections develop when the vanA gene from vancomycin-resistant enterococcus (VRE) transfers to S. aureus. Incl8-like plasmids in VRE and pSK41-like plasmids in S. aureus appear to be important precursors to this transfer.Objective.Identify the prevalence of VRSA precursor organisms.Design.Prospective cohort with embedded case-control study.Participants.Southeastern Michigan adults with chronic lower-extremity wounds.Methods.Adults presenting to 3 southeastern Michigan medical centers during the period February 15 through March 4, 2011, with chronic lower-extremity wounds had wound, nares, and perirectal swab specimens cultured for S. aureus and VRE, which were tested for pSK41-like and Incl8-like plasmids by polymerase chain reaction. We interviewed participants and reviewed clinical records. Risk factors for pSK41-positive S. aureus were assessed among all study participants (cohort analysis) and among only S. aureus-colonized participants (case-control analysis).Results.Of 179 participants with wound cultures, 26% were colonized with methicillin-susceptible S. aureus, 27% were colonized with methicillin-resistant S. aureus, and 4% were colonized with VRE, although only 17% consented to perirectal culture. Six participants (3%) had pSK41-positive S. aureus, and none had Incl8-positive VRE. Having chronic wounds for over 2 years was associated with pSK41-positive S. aureus colonization in both analyses.Conclusions.Colonization with VRSA precursor organisms was rare. Having long-standing chronic wounds was a risk factor for pSK41-positive S. aureus colonization. Additional investigation into the prevalence of VRSA precursors among a larger cohort of patients is warranted.

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Outcomes of Carbapenem-Resistant Klebsiella pneumoniae Infection and the Impact of Antimicrobial and Adjunctive Therapies

Infection Control and Hospital Epidemiology ◽

10.1086/592412 ◽

2008 ◽

Vol 29 (12) ◽

pp. 1099-1106 ◽

Cited By ~ 528

Author(s):

Gopi Patel ◽

Shirish Huprikar ◽

Stephanie H. Factor ◽

Stephen G. Jenkins ◽

David P. Calfee

Keyword(s):

Risk Factors ◽

Klebsiella Pneumoniae ◽

Case Control Study ◽

Patient Survival ◽

Case Control ◽

Factors Associated ◽

Carbapenem Resistant ◽

Matched Case ◽

The Impact ◽

Control Study

Background.Carbapenem-resistant Klebsiella pneumoniae is an emerging healthcare-associated pathogen.Objective.To describe the epidemiology of and clinical outcomes associated with carbapenem-resistant K. pneumoniae infection and to identify risk factors associated with mortality among patients with this type of infection.Setting.Mount Sinai Hospital, a 1,171-bed tertiary care teaching hospital in New York City.Design.Two matched case-control studies.Methods.In the first matched case-control study, case patients with carbapenem-resistant K. pneumoniae infection were compared with control patients with carbapenem-susceptible K. pneumoniae infection. In the second case-control study, patients who survived carbapenem-resistant K. pneumoniae infection were compared with those who did not survive, to identify risk factors associated with mortality among patients with carbapenem-resistant K. pneumoniae infection.Results.There were 99 case patients and 99 control patients identified. Carbapenem-resistant K. pneumoniae infection was independently associated with recent organ or stem-cell transplantation (P = .008), receipt of mechanical ventilation (P = .04), longer length of stay before infection (P = .01), and exposure to cephalosporins (P = .02) and carbapenems (P < .001). Case patients were more likely than control patients to die during hospitalization (48% vs 20%; P < .001) and to die from infection (38% vs 12%; P < .001). Removal of the focus of infection (ie, debridement) was independently associated with patient survival (P = .002). The timely administration of antibiotics with in vitro activity against carbapenem-resistant K. pneumoniae was not associated with patient survival.Conclusions.Carbapenem-resistant K. pneumoniae infection is associated with numerous healthcare-related risk factors and with high mortality. The mortality rate associated with carbapenem-resistant K. pneumoniae infection and the limited antimicrobial options for treatment of carbapenem-resistant K. pneumoniae infection highlight the need for improved detection of carbapenem-resistant K. pneumoniae infection, identification of effective preventive measures, and development of novel agents with reliable clinical efficacy against carbapenem-resistant K. pneumoniae.

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