Long sleep duration: a nonconventional indicator of arterial stiffness in Japanese at high risk of cardiovascular disease: the J-HOP study

Background: Recently, several studies have reported that long sleep duration was independently associated with increased aortic stiffness. On the other hand, high-sensitive C-reactive protein (hs-CRP) was associated with increased aortic stiffness. In this study, the relationships among self-reported sleep duration, hs-CRP and pulse wave velocity (PWV) were investigated in the Japanese at high-risk of cardiovascular disease. In addition, we investigated whether antihypertensive treatment moderated these relationships or not. Methods: Among 4310 patients with one or more cardiovascular risks recruited for the Japan Morning Surge-Home Blood Pressure Study, brachial-ankle PWV and hs-CRP measurement were performed in the 2304 patients (64.7 years old, male 49.6%). A self-administered questionnaire included items on daily sleep duration was used. Results: According to the sleep duration (6h or less,6h to 8h,8h or more per night), significant associations of sleep duration were observed with PWV (1594 vs 1644 vs 1763 cm/s, p<0.0001).In the multiple regression analysis adjustment for confounders including age body mass index, total cholesterol, HbA1c and clinic systolic blood pressure (SBP), long sleep duration (8h or more per night) (B: 29, 95%CI: 1.0-56, p<0.05) and log hs-CRP (B: 25, 95%CI: 3.1-48, p<0.05) were significantly positively associated with PWV. A significant interaction was found between long sleep duration and antihypertensive agent non-use for PWV (p<0.05). Especially, in the group without calcium channel blockers (CCBs), long sleep duration was significantly associated with PWV (p<0.01), while a marginal significant synergetic relationship was observed between long sleep duration and log hs-CRP for PWV (p=0.07). On the other hand, there were no significant interactions between long sleep duration and angiotensin receptor blockers non-use. Conclusions: Long sleep duration and hs-CRP were significant indicators of increased PVW in the high-risk Japanese population. In those without CCBs, long sleep duration served as a strong determinant for arterial stiffness, marginally interacted by low-grade inflammation. CCBs use might be important not to aggravate artery remodeling caused by long sleep duration.

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Long sleep duration and cardiovascular disease: Associations with arterial stiffness and blood pressure variability

Journal of Clinical Hypertension ◽

10.1111/jch.14163 ◽

2020 ◽

Author(s):

Hideaki Matsubayashi ◽

Michiaki Nagai ◽

Keigo Dote ◽

Yuda Turana ◽

Saulat Siddique ◽

...

Keyword(s):

Blood Pressure ◽

Cardiovascular Disease ◽

Arterial Stiffness ◽

Sleep Duration ◽

Blood Pressure Variability ◽

Long Sleep ◽

Disease Associations

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Long sleep duration and risk of increased arterial stiffness in a Chinese population

Medicine ◽

10.1097/md.0000000000022073 ◽

2020 ◽

Vol 99 (36) ◽

pp. e22073 ◽

Cited By ~ 1

Author(s):

Xiaoxue Liu ◽

Qiaofeng Song ◽

Shouling Wu ◽

Xizhu Wang

Keyword(s):

Arterial Stiffness ◽

Sleep Duration ◽

Chinese Population ◽

Long Sleep

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Abstract P072: Short Sleep Duration is Associated with Elevated Homocysteine Levels

Circulation ◽

10.1161/circ.131.suppl_1.p072 ◽

2015 ◽

Vol 131 (suppl_1) ◽

Author(s):

Megan E Petrov ◽

Michael A Grandner ◽

Carol M Baldwin ◽

Matthew P Buman ◽

Shawn D Youngstedt

Keyword(s):

Cardiovascular Disease ◽

Sleep Duration ◽

Multinomial Logistic Regression ◽

Menopausal Status ◽

Short Sleep Duration ◽

Dietary Folate ◽

Short Sleep ◽

Long Sleep ◽

History Of ◽

The Relationship

Introduction: Short and long sleep durations are associated with heightened risk for cardiovascular disease and vascular risk factors. Elevated homocysteine is also associated with greater risk for cardiovascular disease; however, studies have yet to investigate the relationship between sleep duration and homocysteine. Hypothesis: We hypothesized that short and long sleep duration would be associated with clinical levels of homocysteine. Methods: Adults (n=2,469; ≥20y) from the 2005-2006 National Health and Nutrition Examination Survey (NHANES) were assessed for habitual sleep duration (coded as <5, 5, 6, 7, 8, 9, and ≥10hrs) and fasting plasma homocysteine levels (<10 [normative], 10 to <15 [pre-clinical] and ≥15 [clinical] μmol/L). Participants were excluded if pregnant, lactating, missing data on the primary variables, or if they had a history of cardiovascular disease, cancer, diabetes, kidney disease, or diagnosed sleep disorder. Population weighted, multinomial logistic regression analyses assessed the relationship between sleep duration and homocysteine after adjustment for age, sex, race/ethnicity, marital and menopausal status, shift work, dietary folate, alcohol intake, cotinine levels, reported physical activity, hypertension, and reported frequency of cessation of breathing at night. Results: Pre-clinical and clinical levels of homocysteine were present in 13.7% and 2.5% of the sample, respectively. The mean sleep duration was 6.9 ± 1.4 hours. In adjusted analyses, sleep duration was significantly related to homocysteine ( p < 0.001). See Table. Very short sleepers (<5hrs) were more likely to have clinical levels of homocysteine (OR: 3.01, 95%CI: 1.38, 6.57) compared to 7-hr sleepers. Conclusions: In a U.S. representative sample of adults without cardiovascular disease or other major conditions, short sleepers were at greater odds for clinical levels of homocysteine Findings suggest that homocysteine may be one mechanism linking short sleep duration to cardiovascular disease.

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P4412Association of sleep duration with cardio-metabolic risk leading to development of atherosclerotic cardiovascular disease

European Heart Journal ◽

10.1093/eurheartj/ehz745.0816 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

R Matsuo ◽

S Tani ◽

W Atsumi ◽

N Matsumoto

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Relative Risk ◽

Waist Circumference ◽

Sleep Duration ◽

Atherosclerotic Cardiovascular Disease ◽

Metabolic Risk ◽

Model Assessment ◽

Long Sleep ◽

The Relationship

Abstract Background Sleep duration, mostly of short duration, has emerged as a potential factor in adverse cardio-metabolic risk. We investigated the relationship between sleep duration and cardio-metabolic risk leading to atherosclerotic cardiovascular disease (ASCVD). Purpose We examined the association between sleep duration and cardio-metabolic risk in Japanese men. Methods This cross-sectional study was conducted using a sample of 6,907 apparent healthy men who had undergone medical examinations at the Health Planning Center of Nihon University Hospital between April, 2015 and May, 2016. The relationship between waist circumference, homeostasis model assessment of insulin resistance (HOMA-IR), HbA1c, non-high-density lipoprotein cholesterol (non-HDL-C) level, and sleep duration was evaluated. Results Both unusually short and long sleep durations were associated with waist circumference, impaired glucose tolerance and high non-HDL-C level (Figure). Compared with men sleeping 7 to 8 hours, the relative risk of abdominal obesity (defined according to the Japanese criteria for metabolic syndrome as a waist circumference of 85cm≥) among men sleeping ≥8 h was 1.27 (95% Confidence interval (CI), 1.05–1.55, p<0.01); the relative risk of a high HOMA-IR (2.0≥) level among men sleeping <5 h was 1.43 (95% CI, 1.00–2.05, p<0.05); among men sleeping ≥8 h the relative risk was 1.38 (95% CI, 1.08–1.77, p=0.01); the relative risk of a HbA1c level of ≥5.6% (defined as “high” by a specialized life style checkup program for the detection of symptoms of metabolic syndrome in Japan) among men sleeping <5 h was 1.39 (95% CI, 1.01–1.65, p<0.05); the relative risk of a non-HDL-C level of ≥170 mg/dL (defined as “high” by the Japanese Arteriosclerosis Society based on a lipid control target value for the primary prevention of ASCVD) among men sleeping ≥8 was 1.40 (95% CI, 1.13–1.76, p<0.01). These analyses were adjusted for age, psychological stress, and the use of cholesterol-lowering, blood-pressure lowering, and anti-diabetic medications. Conclusion The results suggest that unusually short and long sleep durations may increase cardio-metabolic risk. To further reduce the risk of ASCVD, it may be of particular importance to emphasize adequate sleep duration.

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The Relationships Between the Arterial Stiffness Index Measured at the Radial Artery and Left Ventricular Diastolic Dysfunction in Asymptomatic High Risk Patients Without Atherosclerotic Cardiovascular Disease

International Heart Journal ◽

10.1536/ihj.15-225 ◽

2016 ◽

Vol 57 (1) ◽

pp. 73-79 ◽

Cited By ~ 3

Author(s):

GeeHee Kim ◽

Ji-Hoon Kim ◽

Keon-Woong Moon ◽

Ki-Dong Yoo ◽

Chul-Min Kim ◽

...

Keyword(s):

Cardiovascular Disease ◽

High Risk ◽

Arterial Stiffness ◽

Left Ventricular Diastolic Dysfunction ◽

Left Ventricular ◽

Stiffness Index ◽

Atherosclerotic Cardiovascular Disease ◽

Ventricular Diastolic Dysfunction ◽

Risk Patients ◽

Arterial Stiffness Index

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Increased arterial stiffness in remote Indigenous Australians with high risk of cardiovascular disease

Journal of Hypertension ◽

10.1097/hjh.0b013e328011f766 ◽

2007 ◽

Vol 25 (3) ◽

pp. 585-591 ◽

Cited By ~ 20

Author(s):

Louise J Maple-Brown ◽

Leonard S Piers ◽

Michael F OʼRourke ◽

David S Celermajer ◽

Kerin OʼDea

Keyword(s):

Cardiovascular Disease ◽

High Risk ◽

Arterial Stiffness ◽

Indigenous Australians

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Long Sleep Duration Associated With a Higher Risk of Increased Arterial Stiffness in Males

SLEEP ◽

10.5665/sleep.3920 ◽

2014 ◽

Vol 37 (8) ◽

pp. 1315-1320 ◽

Cited By ~ 27

Author(s):

Tsai-Chen Tsai ◽

Jin-Shang Wu ◽

Yi-Ching Yang ◽

Ying-Hsiang Huang ◽

Feng-Hwa Lu ◽

...

Keyword(s):

Arterial Stiffness ◽

Sleep Duration ◽

Long Sleep

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Sleep duration and risk of cardiovascular events: The SAVE study

International Journal of Stroke ◽

10.1177/1747493020904913 ◽

2020 ◽

Vol 15 (8) ◽

pp. 858-865 ◽

Cited By ~ 1

Author(s):

Jingwei Li ◽

Danni Zheng ◽

Kelly A Loffler ◽

Xia Wang ◽

R Doug McEvoy ◽

...

Keyword(s):

Cardiovascular Disease ◽

Confidence Interval ◽

Sleep Duration ◽

Obstructive Sleep Apnoea ◽

Transient Ischemic Attack ◽

Cardiovascular Events ◽

Sleep Apnoea ◽

Obstructive Sleep ◽

Long Sleep ◽

Ischemic Attack

Background and aim Controversy exists regarding cardiovascular risk in relation to sleep duration. We determined sleep duration and major recurrent cardiovascular event associations in patients with obstructive sleep apnoea and established cardiovascular disease. Methods Secondary analyses of the international, multicenter, Sleep Apnea Cardiovascular Endpoints trial. Sleep duration was estimated from overnight home oximetry (ApneaLink monitor) used for obstructive sleep apnoea diagnosis. Cox proportional hazards models were used to determine associations of categorized sleep duration (<6 h, 6–8 h (reference), and >8 h) and major cardiovascular outcomes: primary composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and any hospitalization for unstable angina, heart failure, or transient ischemic attack; secondary composite of cardiac and cerebral (stroke/transient ischemic attack) events. Results Oximetry-derived sleep duration estimates were available in 2687 participants (mean 61.2 years, 80.9% males) who experienced a total of 436 cardiovascular events over a mean follow-up of 3.7 years. Compared to the reference category, sleep duration was not associated with risk of the primary composite cardiovascular outcome (adjusted hazard ratio (HR) 1.00, 95% confidence interval 0.76–1.33, and HR 1.22, 95% confidence interval 0.98–1.52, for sleep duration <6 and >8 h, respectively). However, long sleep was associated with increased cerebral events (HR 1.67, 95% confidence interval 1.17–2.39; P = 0.005) and stroke alone (HR 1.79, 95% confidence interval 1.22–2.63; P = 0.003). Conclusions Long sleep duration is associated with an increased risk of stroke but not cardiac events in obstructive sleep apnoea patients with existing cardiovascular disease. Clinical trial registration The trial is registered at ClinicalTrials.gov (NCT00738179).

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