Time-range based sequential mining for survival prediction in prostate cancer

Long noncoding RNAs (lncRNAs) have an important role in various life processes of the body, especially cancer. The analysis of disease prognosis is ignored in current prediction on lncRNA–disease associations. In this study, a multiple linear regression model was constructed for lncRNA–disease association prediction based on clinical prognosis data (MlrLDAcp), which integrated the cancer data of clinical prognosis and the expression quantity of lncRNA transcript. MlrLDAcp could realize not only cancer survival prediction but also lncRNA–disease association prediction. Ultimately, 60 lncRNAs most closely related to prostate cancer survival were selected from 481 alternative lncRNAs. Then, the multiple linear regression relationship between the prognosis survival of 176 patients with prostate cancer and 60 lncRNAs was also given. Compared with previous studies, MlrLDAcp had a predominant survival predictive ability and could effectively predict lncRNA–disease associations. MlrLDAcp had an area under the curve (AUC) value of 0.875 for survival prediction and an AUC value of 0.872 for lncRNA–disease association prediction. It could be an effective biological method for biomedical research.

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A Novel Nomogram for Survival Prediction of Patients with Spinal Metastasis from Prostate Cancer

Spine ◽

10.1097/brs.0000000000003888 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Yujie Liu ◽

Lin Li ◽

Dongjie Jiang ◽

Minglei Yang ◽

Xin Gao ◽

...

Keyword(s):

Prostate Cancer ◽

Spinal Metastasis ◽

Survival Prediction

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Discussing personalized prognosis in amyotrophic lateral sclerosis: development of a communication guide

BMC Neurology ◽

10.1186/s12883-020-02004-8 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Remko M. van Eenennaam ◽

Willeke J. Kruithof ◽

Michael A. van Es ◽

Esther T. Kruitwagen-van Reenen ◽

Henk-Jan Westeneng ◽

...

Keyword(s):

Systematic Review ◽

Amyotrophic Lateral Sclerosis ◽

Information Needs ◽

Time Range ◽

Advisory Panel ◽

Survival Prediction ◽

Decisional Capacity ◽

Individual Needs ◽

The Impact ◽

Lateral Sclerosis

Abstract Background Personalized ENCALS survival prediction model reliably estimates the personalized prognosis of patients with amyotrophic lateral sclerosis. Concerns were raised on discussing personalized prognosis without causing anxiety and destroying hope. Tailoring communication to patient readiness and patient needs mediates the impact of prognostic disclosure. We developed a communication guide to support physicians in discussing personalized prognosis tailored to individual needs and preferences of people with ALS and their families. Methods A multidisciplinary working group of neurologists, rehabilitation physicians, and healthcare researchers A) identified relevant topics for guidance, B) conducted a systematic review on needs of patients regarding prognostic discussion in life-limiting disease, C) drafted recommendations based on evidence and expert opinion, and refined and finalized these recommendations in consensus rounds, based on feedback of an expert advisory panel (patients, family member, ethicist, and spiritual counsellor). Results A) Topics identified for guidance were 1) filling in the ENCALS survival model, and interpreting outcomes and uncertainty, and 2) tailoring discussion to individual needs and preferences of patients (information needs, role and needs of family, severe cognitive impairment or frontotemporal dementia, and non-western patients). B) 17 studies were included in the systematic review. C) Consensus procedures on drafted recommendations focused on selection of outcomes, uncertainty about estimated survival, culturally sensitive communication, and lack of decisional capacity. Recommendations for discussing the prognosis include the following: discuss prognosis based on the prognostic groups and their median survival, or, if more precise information is desired, on the interquartile range of the survival probability. Investigate needs and preferences of the patients and their families for prognostic disclosure, regardless of cultural background. If the patient does not want to know their prognosis, with patient permission discuss the prognosis with their family. If the patient is judged to lack decisional capacity, ask the family if they want to discuss the prognosis. Tailor prognostic disclosure step by step, discuss it in terms of time range, and emphasize uncertainty of individual survival time. Conclusion This communication guide supports physicians in tailoring discussion of personalized prognosis to the individual needs and preferences of people with ALS and their families.

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Claims-Based Approach to Predict Cause-Specific Survival in Men With Prostate Cancer

JCO Clinical Cancer Informatics ◽

10.1200/cci.18.00111 ◽

2019 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Paul Riviere ◽

Christopher Tokeshi ◽

Jiayi Hou ◽

Vinit Nalawade ◽

Reith Sarkar ◽

...

Keyword(s):

Prostate Cancer ◽

Claims Data ◽

Prediction Models ◽

Survival Model ◽

Localized Prostate Cancer ◽

Survival Models ◽

Accurate Estimation ◽

Survival Prediction ◽

Data Set ◽

Comorbidity Index

PURPOSE Treatment decisions about localized prostate cancer depend on accurate estimation of the patient’s life expectancy. Current cancer and noncancer survival models use a limited number of predefined variables, which could restrict their predictive capability. We explored a technique to create more comprehensive survival prediction models using insurance claims data from a large administrative data set. These data contain substantial information about medical diagnoses and procedures, and thus may provide a broader reflection of each patient’s health. METHODS We identified 57,011 Medicare beneficiaries with localized prostate cancer diagnosed between 2004 and 2009. We constructed separate cancer survival and noncancer survival prediction models using a training data set and assessed performance on a test data set. Potential model inputs included clinical and demographic covariates, and 8,971 distinct insurance claim codes describing comorbid diseases, procedures, surgeries, and diagnostic tests. We used a least absolute shrinkage and selection operator technique to identify predictive variables in the final survival models. Each model’s predictive capacity was compared with existing survival models with a metric of explained randomness (ρ2) ranging from 0 to 1, with 1 indicating an ideal prediction. RESULTS Our noncancer survival model included 143 covariates and had improved survival prediction (ρ2 = 0.60) compared with the Charlson comorbidity index (ρ2 = 0.26) and Elixhauser comorbidity index (ρ2 = 0.26). Our cancer-specific survival model included nine covariates, and had similar survival predictions (ρ2 = 0.71) to the Memorial Sloan Kettering prediction model (ρ2 = 0.68). CONCLUSION Survival prediction models using high-dimensional variable selection techniques applied to claims data show promise, particularly with noncancer survival prediction. After further validation, these analyses could inform clinical decisions for men with prostate cancer.

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Editorial Comment: Overall survival prediction in metastatic castration-resistant prostate cancer treated with radium-223

International braz j urol ◽

10.1590/s1677-5538.0343.1 ◽

2020 ◽

Vol 46 (4) ◽

pp. 612-613

Author(s):

Rodolfo Borges dos Reis ◽

Valdair Muglia ◽

Eliney F. Faria

Keyword(s):

Prostate Cancer ◽

Overall Survival ◽

Editorial Comment ◽

Survival Prediction ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant ◽

Radium 223 ◽

Overall Survival Prediction

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Discussing Personalized Prognosis in Amyotrophic Lateral Sclerosis: Development of a Communication Guide

10.21203/rs.3.rs-61584/v2 ◽

2020 ◽

Author(s):

Remko M. van Eenennaam ◽

Willeke J. Kruithof ◽

Michael A. van Es ◽

Esther T. Kruitwagen-van Reenen ◽

Henk-Jan Westeneng ◽

...

Keyword(s):

Systematic Review ◽

Amyotrophic Lateral Sclerosis ◽

Information Needs ◽

Time Range ◽

Advisory Panel ◽

Survival Prediction ◽

Individual Needs ◽

The Individual ◽

The Impact ◽

Lateral Sclerosis

Abstract Background: Personalized ENCALS survival prediction model reliably estimates the personalized prognosis of patients with amyotrophic lateral sclerosis. Concerns were raised on discussing personalized prognosis without causing anxiety and destroying hope. Tailoring communication to patient readiness and patient needs mediates the impact of prognostic disclosure. We developed a communication guide to support physicians in discussing personalized prognosis tailored to individual needs and preferences of people with ALS and their families.Methods: A multidisciplinary working group of neurologists, rehabilitation physicians, and healthcare researchers A) identified relevant topics for guidance, B) conducted a systematic review on needs of patients regarding prognostic discussion in life-limiting disease, C) drafted recommendations based on evidence and expert opinion, and refined and finalized these recommendations in consensus rounds, based on feedback of an expert advisory panel (patients, family member, ethicist and spiritual counsellor).Results: A) Topics identified for guidance were 1) filling in the ENCALS survival model, and interpreting outcomes and uncertainty, and 2) tailoring discussion to individual needs and preferences of patients (information needs, role and needs of family, severe cognitive impairment or frontotemporal dementia, and non-western patients). B) 17 studies were included in the systematic review. C) Consensus procedures on drafted recommendations focused on selection of outcomes, uncertainty about estimated survival, culturally sensitive communication, and lack of decisional capacity.Recommendations for discussing the prognosis include the following: discuss prognosis based on the prognostic groups and their median survival, or, if more precise information is desired, on the interquartile range of the survival probability. Investigate needs and preferences of the patients and their families for prognostic disclosure, regardless of cultural background. If the patient does not want to know their prognosis, with patient permission discuss the prognosis with their family. If the patient is judged to lack decisional capacity, ask the family if they want to discuss the prognosis. Tailor prognostic disclosure step by step, discuss it in terms of time range, and emphasize uncertainty of individual survival time.Conclusion: This communication guide supports physicians in tailoring discussion of personalized prognosis to the individual needs and preferences of people with ALS and their families.

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Discussing Personalized Prognosis in Amyotrophic Lateral Sclerosis: Development of a Communication Guide

10.21203/rs.3.rs-61584/v1 ◽

2020 ◽

Author(s):

Remko M. van Eenennaam ◽

Willeke J. Kruithof ◽

Michael A. van Es ◽

Esther T. Kruitwagen-van Reenen ◽

Henk-Jan Westeneng ◽

...

Keyword(s):

Systematic Review ◽

Amyotrophic Lateral Sclerosis ◽

Information Needs ◽

Time Range ◽

Advisory Panel ◽

Survival Prediction ◽

Decisional Capacity ◽

Individual Needs ◽

The Impact ◽

Lateral Sclerosis

Abstract Background: Personalized ENCALS survival prediction model reliably estimates the personalized prognosis of patients with amyotrophic lateral sclerosis. Concerns were raised on discussing personalized prognosis without causing anxiety and destroying hope. Tailoring communication to patient readiness and patient needs mediates the impact of prognostic disclosure. We developed a communication guide to support physicians in discussing personalized prognosis tailored to individual needs and preferences of people with ALS and their families.Methods: A multidisciplinary working group of neurologists, rehabilitation physicians, and healthcare researchers A) identified relevant topics for guidance, B) conducted a systematic review on needs of patients regarding prognostic discussion in life-limiting disease, C) drafted recommendations based on evidence and expert opinion, and refined and finalized these recommendations in consensus rounds, based on feedback of an expert advisory panel (patients, family member, ethicist and spiritual counsellor).Results: A) Topics identified for guidance were 1) filling in the ENCALS survival model, and interpreting outcomes and uncertainty, and 2) tailoring discussion to individual needs and preferences of patients (information needs, role and needs of family, severe cognitive impairment or frontotemporal dementia, and non-western patients). B) 17 studies were included in the systematic review. C) Consensus procedures on drafted recommendations focused on selection of outcomes, uncertainty about estimated survival, culturally sensitive communication, and lack of decisional capacity.Communication guide: We recommend discussing prognosis based on the prognostic groups and their median survival, or, if more precise information is desired, on the interquartile range of the survival probability. Regardless of cultural background, investigate needs and preferences of the patients and their families regarding prognostic disclosure. If the patient does not want to know their prognosis, with patient permission this can be discussed with their family. If the patient is judged to lack decisional capacity, ask the family if they want to discuss the prognosis. Tailor prognostic disclosure step by step, discuss it in terms of time range, and emphasize uncertainty of individual survival time.Conclusion: This communication guide supports physicians in tailoring discussion of personalized prognosis to the individual needs and preferences of people with ALS and their families.

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