Study of Common NOD2 Gene Polymorphisms as a Risk Factor for Development of Complications in Indian Patients of Liver Cirrhosis

2016 ◽  
Vol 6 ◽  
pp. S49
Author(s):  
Manish Tiwari ◽  
Mohd T. Noor ◽  
Nivesh Seehra ◽  
Sunil Jain ◽  
Ravindra Kumar ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Risk Factor ◽  
Gene Polymorphisms ◽  
Indian Patients

scholarly journals Association between apolipoprotein gene polymorphisms and hyperlipidemia: a meta-analysis

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xiao-Ning Zhao ◽  
Quan Sun ◽  
You-Qin Cao ◽  
Xiao Ran ◽  
Yu Cao
Keyword(s):  
Risk Factor ◽  
Cerebrovascular Disease ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Control Group ◽  
Case Group ◽  
Healthy Controls ◽  
Ε4 Allele ◽  
Different Populations ◽  
The Impact

Abstract Background Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Over recent years, a number of studies have explored the impact of apolipoprotein genetic polymorphisms in hyperlipidemia, but considerable differences and uncertainty have been found in their association with different populations from different regions. Results A total of 59 articles were included, containing in total 13,843 hyperlipidemia patients in the case group and 15,398 healthy controls in the control group. Meta-analysis of the data indicated that APOA5–1131 T > C, APOA1 -75 bp, APOB XbaI, and APOE gene polymorphisms were significantly associated with hyperlipidemia, with OR values of 1.996, 1.228, 1.444, and 1.710, respectively. All P-values were less than 0.05. Conclusions Meta-analysis of the data indicated that the C allele of APOA5 1131 T > C, the A allele at APOA1-75 bp, the APOB XbaI T allele, and the ε2 and ε4 allele of APOE were each a risk factor for susceptibility for hyperlipidemia.

scholarly journals Association of Cystathionine β-Synthase Gene Polymorphisms With Preeclampsia

2018 ◽  
Vol 24 (9_suppl) ◽  
pp. 285S-293S ◽  
Author(s):  
Mercedes Piedad de León Bautista ◽  
Mirza Romero-Valdovinos ◽  
Beatriz Zavaleta-Villa ◽  
Arony Martínez-Flores ◽  
Angélica Olivo-Díaz
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Base Pair ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
High Plasma ◽  
Case Control ◽  
Related Factor ◽  
Mexican Women ◽  
Control Study

Preeclampsia (PE) is a pregnancy disorder that increases maternal and fetal morbidity and mortality worldwide. High plasma levels of homocysteine (Hcy) are a risk factor for several cardiovascular diseases. Cystathionine β-synthase (CBS) plays an important role in Hcy homeostasis catalyzing the irreversible degradation of Hcy to cystathionine, protecting the endothelium from injury caused by hypoxia. Several mutations and polymorphisms may alter the expression of the CBS gene, resulting in variable levels of Hcy. The purpose of this study was to investigate the association of CBS gene polymorphisms with PE in Mexican women. A case–control study consisting of 129 pregnant women with PE (37 severe and 92 mild) and 173 women with uncomplicated pregnancies was performed. Polymorphisms, such as G797A, C785T, T833C, G919A, T959C, C1105T, and 844ins68 base pair, in the CBS gene were genotyped. The polymorphism G797A was monomorphic in cases with the presence of only G797A-G allele. Allele C785T-T and genotype C785T-C/T were associated with susceptibility in severe and mild PE. Alleles G797A-G and T959C-T were associated with susceptibility only in severe PE. Haplotype TGTWGTC was of susceptibility for severe PE and of protection for mild PE. Haplotypes CGTWGCC and CATWGTC seem to be protective for severe PE, but the latter is related to susceptibility in mild PE. The results suggest that C785T, G797A, and T959C mutations are contributing in different ways in severe and mild PE in our population and could be count as another related factor for this disease.

scholarly journals Maternal gene polymorphisms of folate metabolism as genetic risk factor for Down syndrome in North Indian population

2014 ◽  
Vol 7 (Suppl 1) ◽  
pp. P120
Author(s):  
Sushil Kumar Jaiswal ◽  
Ashok Kumar ◽  
Vineeta Gupta ◽  
Anjali Rani ◽  
Amit Kumar Rai
Keyword(s):  
Down Syndrome ◽  
Risk Factor ◽  
Genetic Risk ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
Folate Metabolism ◽  
Genetic Risk Factor ◽  
North Indian Population ◽  
Maternal Gene

[763] CRITICAL EVALUATION OF CANDIDATE GENE POLYMORPHISMS IN THE DEVELOPMENT OF ALCOHOLIC LIVER CIRRHOSIS

2007 ◽  
Vol 46 ◽  
pp. S286
Author(s):  
F. Stickel ◽  
C. Oesterreicher ◽  
V. Schneider ◽  
J. Halangk ◽  
T. Berg ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Candidate Gene ◽  
Gene Polymorphisms ◽  
Critical Evaluation ◽  
Alcoholic Liver Cirrhosis

Cryptogenic Stroke in the Young: Role of Candidate Gene Polymorphisms in Indian Patients with Ischemic Etiology

2021 ◽  
Vol 69 (6) ◽  
pp. 1655
Author(s):  
ChristhunesaS Christudass ◽  
BoddaS B Salomi ◽  
Raja Solomon ◽  
VijayPrakash Turaka ◽  
Sanjith Aaron
Keyword(s):  
Candidate Gene ◽  
Gene Polymorphisms ◽  
Cryptogenic Stroke ◽  
Indian Patients ◽  
Stroke In The Young

Hepatocellular carcinoma in the non-cirrhotic liver

2021 ◽  
pp. 1-14
Author(s):  
Dong Yi ◽  
Wang Wen-Ping ◽  
Won Jae Lee ◽  
Maria Franca Meloni ◽  
Dirk-Andre Clevert ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Risk Factor ◽  
High Risk ◽  
Current Knowledge ◽  
Cirrhotic Liver ◽  
Imaging Features ◽  
Advanced Stage ◽  
High Risk Factor ◽  
Cirrhotic Patients

Liver cirrhosis is an established high-risk factor for HCC and the majority of patients diagnosed with HCC have cirrhosis. However, HCC also arises in non-cirrhotic livers in approximately 20 %of all cases. HCC in non-cirrhotic patients is often clinically silent and surveillance is usually not recommended. HCC is often diagnosed at an advanced stage in these patients. Current information about HCC in patients with non-cirrhotic liver is limited. Here we review the current knowledge on epidemiology, clinical features and imaging features of those patiens.

Sign in / Sign up

Export Citation Format

Share Document