Rational design of process parameters for carbon-neutral and sulfur-free motor fuel production from second-generation biomass generated syngas

2021 ◽  
Vol 279 ◽  
pp. 123559 ◽  
Author(s):  
Shashank Bahri ◽  
Uttaran Basak ◽  
Sreedevi Upadhyayula
Keyword(s):  
Process Parameters ◽  
Rational Design ◽  
Second Generation ◽  
Motor Fuel ◽  
Fuel Production ◽  
Carbon Neutral

scholarly journals WASTEWATER TREATMENT WITH BIOCONVERSION FOR MOTOR FUEL PRODUCTION

ScienceRise ◽  
2020 ◽  
pp. 66-72
Author(s):  
Sergii Shamanskyi ◽  
Sergii Boichenko ◽  
Lesia Pavliukh
Keyword(s):  
Wastewater Treatment ◽  
Culture Medium ◽  
Motor Fuel ◽  
Biofuel Production ◽  
Phosphorus Compounds ◽  
Biogenic Elements ◽  
Fuel Production ◽  
Nitrogen And Phosphorus ◽  
Phosphorous Compounds ◽  
Technological Product

The object of research: the process of wastewater treatment using bioconversion for subsequent motor fuel production. Investigated problem: improving the efficiency of bioconversion process for biofuel production with simultaneous wastewater treatment by removing nitrogen and phosphorous compounds. The main scientific results: providing the possibility of biofuel production with energy and economic inefficiency. It is done by combining the process of motor biofuel production with the process of treating wastewater from biogenic elements makes it perspective for commercial use. Traditional technology for the production of motor biofuels from microalgae includes cultivation, harvesting, dehydration and drying of biomass, extraction of oils from them and subsequent production of methyl esters and glycerol. Such technology is often not economically effective. It requires significant amount of energy for carrying out all necessary processes. In addition, it requires significant expenditures of water and nutrients. The use of nutrient-rich wastewater as a culture medium for the cultivation of microalgae allows not only to reduce costs, but also to purify wastewater from nitrogen and phosphorus compounds, which makes this process economically effective. The area of practical use of the research results: Sewage and gray water treatment plants. Industrial and agricultural effluents treatment plants. Different types of enterprises, which have wastewater enriched with nitrogen and phosphorous compounds. Innovative technological product: The technology of microalgae cultivation using wastewater as a culture medium. The technology allows effectively purifying used wastewaters from nitrogen and phosphorous compounds with no waste at the end. Scope of the innovative technological product: Improved technology of motor biofuel production with simultaneous wastewater purification, which is economically effective and environmentally safe.

scholarly journals The Binding Mode of Second-Generation Sulfonamide Inhibitors of MurD: Clues for Rational Design of Potent MurD Inhibitors

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52817 ◽  
Author(s):  
Mihael Simčič ◽  
Izidor Sosič ◽  
Milan Hodošček ◽  
Hélène Barreteau ◽  
Didier Blanot ◽  
...  
Keyword(s):  
Rational Design ◽  
Second Generation ◽  
Binding Mode

scholarly journals Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases

2020 ◽  
pp. jbc.RA120.015735
Author(s):  
Catherine A Hurd ◽  
Paul Brear ◽  
Jefferson Revell ◽  
Sarah Ross ◽  
Helen R Mott ◽  
...  
Keyword(s):  
Rational Design ◽  
First Generation ◽  
Second Generation ◽  
Affinity Maturation ◽  
Peptide Inhibitors ◽  
Binding Domain ◽  
Stapled Peptides ◽  
Stapled Peptide ◽  
Protein Protein Interaction ◽  
Ral Gtpases

Ral GTPases have been implicated as critical drivers of cell growth and metastasis in numerous Ras-driven cancers. We have previously reported stapled peptides, based on the Ral effector RLIP76, that can disrupt Ral signaling. Stapled peptides are short peptides that are locked into their bioactive form using a synthetic brace. Here, using an affinity maturation of the RLIP76 Ral-binding domain, we identified several sequence substitutions that together improve binding to Ral proteins by more than 20-fold. Hits from the selection were rigorously analyzed to determine the contributions of individual residues and two 1.5 Å co-crystal structures of the tightest-binding mutants in complex with RalB revealed key interactions. Insights gained from this maturation were used to design second-generation stapled peptides based on RLIP76 that exhibited vastly improved selectivity for Ral GTPases when compared to the first-generation lead peptide. The binding of second-generation peptides to Ral proteins was quantified and the binding site of the lead peptide on RalB was determined by NMR. Stapled peptides successfully competed with multiple Ral-effector interactions in cellular lysates.  Our findings demonstrate how manipulation of a native binding partner can assist in the rational design of stapled peptide inhibitors targeting a protein–protein interaction.

scholarly journals Thermochemical CO2 splitting using double perovskite-type Ba2Ca0.66Nb1.34−xFexO6−δ

2017 ◽  
Vol 5 (15) ◽  
pp. 6874-6883 ◽  
Author(s):  
Suresh Mulmi ◽  
Haomin Chen ◽  
Azfar Hassan ◽  
Jose F. Marco ◽  
Frank J. Berry ◽  
...  
Keyword(s):  
Double Perovskite ◽  
Fuel Production ◽  
Perovskite Materials ◽  
Carbon Neutral ◽  
Current Systems ◽  
Perovskite Type

Fe-doped double perovskite materials show promise for renewable-derived carbon-neutral fuel production at significantly lower temperatures than current systems.

scholarly journals Second-Generation Androgen Receptor Antagonists as Hormonal Therapeutics for Three Forms of Prostate Cancer

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2448
Author(s):  
Pravien Rajaram ◽  
Alyssa Rivera ◽  
Kevin Muthima ◽  
Nicholas Olveda ◽  
Hubert Muchalski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Survival Time ◽  
Rational Design ◽  
Second Generation ◽  
Interdisciplinary Collaboration ◽  
Castration Resistant Prostate Cancer ◽  
Free Survival ◽  
Castration Resistant ◽  
Fda Approval

Enzalutamide is the first second-generation nonsteroidal androgen receptor (AR) antagonist with a strong binding affinity to AR. Most significantly, enzalutamide can prolong not only overall survival time and metastatic free survival time for patients with lethal castration-resistant prostate cancer (CRPC), but also castration-resistant free survival time for patients with castration-sensitive prostate cancer (CSPC). Enzalutamide has thus been approved by the US Food and Drug Administration (FDA) for the treatment of both metastatic (in 2012) and non-metastatic (in 2018) CRPC, as well as CSPC (2019). This is an inspiring drug discovery story created by an amazing interdisciplinary collaboration. Equally important, the successful clinical use of enzalutamide proves the notion that the second-generation AR antagonists can serve as hormonal therapeutics for three forms of advanced prostate cancer. This has been further verified by the recent FDA approval of the other two second-generation AR antagonists, apalutamide and darolutamide, for the treatment of prostate cancer. This review focuses on the rational design and discovery of these three second-generation AR antagonists, and then highlights their syntheses, clinical studies, and use. Strategies to overcome the resistance to the second-generation AR antagonists are also reviewed.

Biomass derived feedstock co-processing with vacuum gas oil for second-generation fuel production in FCC units

2010 ◽  
Vol 96 (3-4) ◽  
pp. 476-485 ◽  
Author(s):  
Gabriella Fogassy ◽  
Nicolas Thegarid ◽  
Guy Toussaint ◽  
Andre C. van Veen ◽  
Yves Schuurman ◽  
...  
Keyword(s):  
Second Generation ◽  
Vacuum Gas Oil ◽  
Gas Oil ◽  
Fuel Production

scholarly journals Development opportunities of biomass-based ethanol production in relation to starch- and cellulosebased bioethanol production

2013 ◽  
pp. 71-75
Author(s):  
Zoltán Balla
Keyword(s):  
Ethanol Production ◽  
Life Cycle Analysis ◽  
Liquid Fuel ◽  
First Generation ◽  
Second Generation ◽  
Point Of View ◽  
Raw Material ◽  
Bioethanol Production ◽  
Fuel Production ◽  
Second Generation Bioethanol

The biomass is such a row material that is available in large quantities and it can be utilizied by the biotechnology in the future. Nowadays the technology which can process ligno cellulose and break down into fermentable sugars is being researched. One possible field of use of biomass is the liquid fuel production such as ethanol production. Based on the literary life cycle analysis, I compared the starch-based (first generation) to cellulose-based (second generation) bioethanol production in my study considering into account various environmental factors (land use, raw material production, energy balance). After my examination I came to the conclusion that the use of bioethanol, independent of its production technology, is favorable from environmental point of view but the application of second generation bioethanol has greater environmentally benefits.

scholarly journals Fast pyrolysis oil from pinewood chips co-processing with vacuum gas oil in an FCC unit for second generation fuel production

Fuel ◽  
2017 ◽  
Vol 188 ◽  
pp. 462-473 ◽  
Author(s):  
Andrea de Rezende Pinho ◽  
Marlon B.B. de Almeida ◽  
Fabio Leal Mendes ◽  
Luiz Carlos Casavechia ◽  
Michael S. Talmadge ◽  
...  
Keyword(s):  
Second Generation ◽  
Fast Pyrolysis ◽  
Vacuum Gas Oil ◽  
Pyrolysis Oil ◽  
Gas Oil ◽  
Fuel Production
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