scholarly journals Current use was established and Cochrane guidance on selection of social theories for systematic reviews of complex interventions was developed

2016 ◽  
Vol 75 ◽  
pp. 78-92 ◽  
Author(s):  
Jane Noyes ◽  
Maggie Hendry ◽  
Andrew Booth ◽  
Jackie Chandler ◽  
Simon Lewin ◽  
...  
Keyword(s):  
Systematic Reviews ◽  
Complex Interventions ◽  
Social Theories ◽  
Selection Of

scholarly journals Patient-Reported Outcomes in Inflammatory Bowel Disease: A Measurement of Effect in Research and Clinical Care

2021 ◽  
Vol 12 (2) ◽  
pp. 225-237
Author(s):  
Jane Fletcher ◽  
Sheldon C. Cooper ◽  
Amelia Swift
Keyword(s):  
Inflammatory Bowel Disease ◽  
Systematic Reviews ◽  
Bowel Disease ◽  
Core Outcome Set ◽  
Core Outcome ◽  
Health Measurement ◽  
Outcome Set ◽  
Patient Reported ◽  
Inflammatory Bowel ◽  
Selection Of

The measurement of outcomes is key in evaluating healthcare or research interventions in inflammatory bowel disease (IBD). In patient-centred care, patient-reported outcome measures (PROMs) are central to this evaluation. In this review, we provide an overview of validated, adult disease-specific PROMs developed for use in IBD. Our aim is to assist clinicians and researchers in selection of PROMs to measure outcomes in their patient cohort. The Consensus-based Standards for the Selection of Health Measurement Instruments database of systematic reviews was the primary resource used to identify PROMs used in IBD. Search terms were ‘Crohn’s disease’, ‘ulcerative colitis’, and ‘IBD’. Seven systematic reviews were identified from this search. In addition, the publication by the IBD Core Outcome Set Working Group was used to identify further PROMs. Three systematic reviews were excluded as they did not meet the inclusion criteria. From the five included systematic reviews, we identified 21 PROMs and their shortened versions. In conclusion, it does not appear that any one PROM is entirely suitable for both research and clinical practice. Overall, the IBDQ-32 is most widely used in research but has the limitation of cost, whereas the IBD-Control has been recommended in the clinical core outcome set.

Complex interventions and their implications for systematic reviews: A pragmatic approach

2015 ◽  
Vol 52 (7) ◽  
pp. 1211-1216 ◽  
Author(s):  
Mark Petticrew ◽  
Laurie Anderson ◽  
Randy Elder ◽  
Jeremy Grimshaw ◽  
David Hopkins ◽  
...  
Keyword(s):  
Systematic Reviews ◽  
Complex Interventions ◽  
Pragmatic Approach

scholarly journals The Reporting Quality Assessment of Complex Interventions’ Articles in Traditional Chinese Medicine

2013 ◽  
Vol 2013 ◽  
pp. 1-8
Author(s):  
Meng Wu ◽  
Jingqing Hu ◽  
Biaoyan Liu
Keyword(s):  
Quality Control ◽  
Clinical Trials ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Complex Interventions ◽  
Reporting Quality ◽  
Chinese Journal ◽  
Inform Consent ◽  
Ethical Approval ◽  
Selection Of

Objective.To realize the current situation and problems of complex interventions’ clinical trials.Methods.Searching at Chinese Journal Integrated Traditional and Western Medicine and Journal of Traditional Chinese Medicine from 2007 to 2012 by hand, we identified complex interventions’ articles, and then we used the proposed criteria of complex interventions and CONSORT FOR TCM to evaluate.Results.All data is presented as counts with percentages and details in tables.Conclusion.Our evaluation presented that complex interventions have many defects: the selection of the intervention’s components lacks rationale, complex interventions were short of fundamental researches, components’ interactions were ambiguous, and the advantages of complex interventions were not mentioned. Furthermore, explanation of sample size, blind, quality control, ethical approval, and inform consent were neglected in different degrees.

scholarly journals Qualitative evidence synthesis for complex interventions and guideline development: clarification of the purpose, designs and relevant methods

2019 ◽  
Vol 4 (Suppl 1) ◽  
pp. e000882 ◽  
Author(s):  
Kate Flemming ◽  
Andrew Booth ◽  
Ruth Garside ◽  
Özge Tunçalp ◽  
Jane Noyes
Keyword(s):  
Qualitative Research ◽  
Systematic Reviews ◽  
Guideline Development ◽  
Evidence Synthesis ◽  
Complex Interventions ◽  
Real Life ◽  
Synthesis Methods ◽  
Qualitative Evidence Synthesis ◽  
Qualitative Evidence ◽  
Broad Term

This paper is one of a series exploring the implications of complexity for systematic reviews and guideline development, commissioned by the WHO. The paper specifically explores the role of qualitative evidence synthesis. Qualitative evidence synthesis is the broad term for the group of methods used to undertake systematic reviews of qualitative research evidence. As an approach, qualitative evidence synthesis is increasingly recognised as having a key role to play in addressing questions relating to intervention or system complexity, and guideline development processes. This is due to the unique role qualitative research can play in establishing the relative importance of outcomes, the acceptability, fidelity and reach of interventions, their feasibility in different settings and potential consequences on equity across populations. This paper outlines the purpose of qualitative evidence synthesis, provides detail of how qualitative evidence syntheses can help establish understanding and explanation of the complexity that can occur in relation to both interventions and systems, and how qualitative evidence syntheses can contribute to evidence to decision frameworks. It provides guidance for the choice of qualitative evidence synthesis methods in the context of guideline development for complex interventions, giving ‘real life’ examples of where this has occurred. Information to support decision-making around choice qualitative evidence synthesis methods in the context of guideline development is provided. Approaches for reporting qualitative evidence syntheses are discussed alongside mechanisms for assessing confidence in the findings of a review.

scholarly journals Why and How Should We Integrate Biomarkers into Complex Trials? A Discussion on Paradigms and Clinical Research Strategies

2019 ◽  
Vol 26 (5) ◽  
pp. 343-352
Author(s):  
Frauke Musial ◽  
Scott Mist  ◽  
Sara Warber ◽  
Mary Jo Kreitzer ◽  
Cheryl Ritenbaugh ◽  
...  
Keyword(s):  
Expert Panel ◽  
Complex Interventions ◽  
Research Approach ◽  
Research Strategies ◽  
Disease Condition ◽  
Nonspecific Factors ◽  
Multiple Symptoms ◽  
The Relationship ◽  
Selection Of ◽  
Complementary And Alternative

Background: Research in complementary and alternative medicine (CAM) encounters a variety of challenges, such as potentially synergistic, multimodal, and complex interventions which are often dependent on the relationship between practitioner and patient, on specific settings, and on patients’ individual preferences, expectations, beliefs, and motivations. Moreover, patients seeking CAM care often suffer from chronic disease conditions, and multiple symptoms and/or pathologies. On the other hand, CAM interventions are often challenged as being solely dependent on subjective and nonspecific factors without biologically based mechanisms of action. If we agree that biomarkers as outcomes are important for the understanding of CAM interventions, a hypothesis- and strategy-driven process for the selection of the most appropriate biomarkers is needed. Methods: This paper presents the results of an expert panel on how to integrate biomarkers in whole system research of an interdisciplinary workshop on research methodology in CAM held in November 2012. Results: The following main CAM research challenges were identified: (a) finding appropriate biomarkers, which are able to picture the complex pathophysiological pathways and likewise complex interventions under study; (b) integrating these biomarkers into clinical trials in CAM; and (c) identifying the biomarkers specific to the particular CAM intervention being applied. Conclusion: The paper provides a disease/condition/symptom- and intervention-driven strategy regarding how to identify the outcomes of interest and possible related biomarkers. The research approach presented here allows the selected biomarkers to be grounded in conventional physiology/pathophysiology as well as complementary and alternative concepts, including traditional systems of medicine. The goal is to provide researchers in the field with a framework on how to integrate biomarkers into complex trials.

scholarly journals Interventions for Addressing Anemia Among Children and Adolescents: An Overview of Systematic Reviews

2021 ◽  
Vol 8 ◽  
Author(s):  
Prasanna Mithra ◽  
Mahalaqua Nazli Khatib ◽  
Anju Pradhan Sinha ◽  
Nithin Kumar ◽  
Ramesh Holla ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Systematic Reviews ◽  
Age Groups ◽  
Public Health Problem ◽  
Decision Makers ◽  
Current Evidence ◽  
Motor Impairments ◽  
Overview Of Systematic Reviews ◽  
Inclusion Results ◽  
Selection Of

Context: Anemia is a public health problem that can lead to growth, cognitive, and motor impairments.Objective: To collate evidence on interventions for addressing childhood and adolescent anemia.Methods: In this overview of systematic reviews, we included Cochrane as well as non-Cochrane systematic reviews (SRs) irrespective of language and publication status. Two sets of review authors independently screened articles for eligibility and extracted data from relevant SRs. We present data in a tabular format and summarize results based on outcome reported, age of participants, and type of interventions. We also adopt a “measurement for change” approach to assess the utility of measurement for development of interventions in childhood and adolescent anemia.Results: Our search yielded 2,601 records of which 31 SRs were found eligible for inclusion. Results were favorable for fortification and supplementation with clear reduction in the risk of anemia and increase in hemoglobin levels across all age groups. Other interventions reported by the SRs were inconclusive and suggest further research.Conclusions: Current evidence suggests that fortification or supplementation with iron and micronutrients leads to better reduction in the risk of anemia and improvements in hemoglobin levels among children and adolescents. Results of this overview can help decision makers in informing selection of interventions to address childhood and adolescent anemia.Review Registration: PROSPERO CRD42016053687.

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