Effect of sustained release of rhBMP-2 from dried and wet hyaluronic acid hydrogel carriers compared with direct dip coating of rhBMP-2 on peri-implant osteogenesis of dental implants in canine mandibles

2016 ◽  
Vol 44 (2) ◽  
pp. 116-125 ◽  
Author(s):  
Hui Pan ◽  
Jeong Joon Han ◽  
Yong-Doo Park ◽  
Tae Hyung Cho ◽  
Soon Jung Hwang
Keyword(s):  
Hyaluronic Acid ◽  
Sustained Release ◽  
Dental Implants ◽  
Dip Coating ◽  
Hyaluronic Acid Hydrogel

Preparation and characterization of injectable chitosan–hyaluronic acid hydrogels for nerve growth factor sustained release

2016 ◽  
Vol 32 (2) ◽  
pp. 146-162 ◽  
Author(s):  
Haixing Xu ◽  
Lingxi Zhang ◽  
Yun Bao ◽  
Xiumei Yan ◽  
Yixia Yin ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Sustained Release ◽  
Peripheral Nerve Regeneration ◽  
Nerve Growth ◽  
Nerve Conduits ◽  
Hyaluronic Acid Hydrogel

The usage of hollow nerve conduits shows inferior recovery effect on the repair of peripheral nerve defects. In this study, a biocompatible and biodegradable pH-induced injectable chitosan–hyaluronic acid hydrogel for nerve growth factor encapsulation and sustained release was developed as the fillers in the lumen of hollow nerve conduit to reform its microenvironment for peripheral nerve regeneration. The physicochemical properties of hydrogel were characterized by gelation time, Fourier transform infrared spectroscopy, scanning electron microscopy, compressive modulus, porosity, swelling ratio, and in vitro degradation. The in vitro nerve growth factor release profiles and cell evaluation were also investigated. The results show that the structure of chitosan–hyaluronic acid hydrogel is composed of interconnected channels with a controllable pore diameter ranging from 20 to 100 µm. The hydrogel can be degraded more than 70% within 8 weeks in vitro and is available for nerve growth factor sustained release. The chitosan–hyaluronic acid/nerve growth factor hydrogel is non-toxic and suitable for adhesion and proliferation of nerve cells and capable of maintaining nerve growth factor activity. Therefore, it could be a promising intraluminal filler of nerve conduits for peripheral nerve regeneration in neural tissue engineering.

scholarly journals Drug-loaded hyaluronic acid hydrogel as a sustained-release regimen with dual effects in early intervention of tendinopathy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ming-Yen Hsiao ◽  
An-Ci Lin ◽  
Wei-Hao Liao ◽  
Tyng-Guey Wang ◽  
Chia-Hsien Hsu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Early Intervention ◽  
Sustained Release ◽  
Hyaluronic Acid Hydrogel

scholarly journals Subcutaneously Injectable Hyaluronic Acid Hydrogel for Sustained Release of Donepezil with Reduced Initial Burst Release: Effect of Hybridization of Microstructured Lipid Carriers and Albumin

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 864
Author(s):  
Nae-Won Kang ◽  
So-Yeon Yoon ◽  
Sungho Kim ◽  
Na-Young Yu ◽  
Ju-Hwan Park ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hyaluronic Acid ◽  
Sustained Release ◽  
Subcutaneous Administration ◽  
Burst Release ◽  
Initial Burst ◽  
Initial Burst Release ◽  
Ache Inhibitors ◽  
Hyaluronic Acid Hydrogel

The daily oral administration of acetylcholinesterase (AChE) inhibitors for Alzheimer’s disease features low patient compliance and can lead to low efficacy or high toxicity owing to irregular intake. Herein, we developed a subcutaneously injectable hyaluronic acid hydrogel (MLC/HSA hydrogel) hybridized with microstructured lipid carriers (MLCs) and human serum albumin (HSA) for the sustained release of donepezil (DNP) with reduced initial burst release. The lipid carrier was designed to have a microsized mean diameter (32.6 ± 12.8 µm) to be well-localized in the hydrogel. The hybridization of MLCs and HSA enhanced the structural integrity of the HA hydrogel, as demonstrated by the measurements of storage modulus (G′), loss modulus (G″), and viscosity. In the pharmacokinetic study, subcutaneous administration of MLC/HSA hydrogel in rats prolonged the release of DNP for up to seven days and reduced the initial plasma concentration, where the Cmax value was 0.3-fold lower than that of the control hydrogel without a significant change in the AUClast value. Histological analyses of the hydrogels supported their biocompatibility for subcutaneous injection. These results suggest that a new hybrid MLC/HSA hydrogel could be promising as a subcutaneously injectable controlled drug delivery system for the treatment of Alzheimer’s disease.

Synergistic regenerative effects of functionalized endometrial stromal cells with hyaluronic acid hydrogel in a murine model of uterine damage

2019 ◽  
Vol 89 ◽  
pp. 139-151 ◽  
Author(s):  
Yoon Young Kim ◽  
Kyu-Hyung Park ◽  
Yong Jin Kim ◽  
Moon Suk Kim ◽  
Hung Ching Liu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Murine Model ◽  
Stromal Cells ◽  
Endometrial Stromal Cells ◽  
Hyaluronic Acid Hydrogel

A chondrogenesis induction system based on a functionalized hyaluronic acid hydrogel sequentially promoting hMSC proliferation, condensation, differentiation, and matrix deposition

2021 ◽  
Vol 122 ◽  
pp. 145-159
Author(s):  
Binhong Teng ◽  
Siqi Zhang ◽  
Jijia Pan ◽  
Ziqian Zeng ◽  
Yang Chen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Matrix Deposition ◽  
Induction System ◽  
Hyaluronic Acid Hydrogel

An in vitro hyaluronic acid hydrogel based platform to model dormancy in brain metastatic breast cancer cells

2020 ◽  
Vol 107 ◽  
pp. 65-77 ◽  
Author(s):  
Akshay A. Narkhede ◽  
James H. Crenshaw ◽  
David K. Crossman ◽  
Lalita A. Shevde ◽  
Shreyas S. Rao
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Metastatic Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
Hyaluronic Acid Hydrogel

Morphological and morphometric analyses of crushed sciatic nerves after application of a purified protein from natural latex and hyaluronic acid hydrogel

2014 ◽  
Vol 32 (5) ◽  
pp. 164-170 ◽  
Author(s):  
Vanessa Cristina Pereira Barreiros ◽  
Fernando José Dias ◽  
Mamie Mizusaki Iyomasa ◽  
Joaquim Coutinho-Netto ◽  
Luiz Gustavo de Sousa ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Morphometric Analyses ◽  
Sciatic Nerves ◽  
Hyaluronic Acid Hydrogel

Self-Crosslinked Hyaluronic Acid Hydrogel (PureRegen Gel Sinus) in Ethmoidectomy: A Randomized, Controlled Trial

2014 ◽  
Vol 151 (1_suppl) ◽  
pp. P127-P127 ◽  
Author(s):  
Keith E. Matheny ◽  
Ewen Tseng ◽  
Kenny B. Carter ◽  
William B. Cobb ◽  
Karen J. Fong
Keyword(s):  
Randomized Controlled Trial ◽  
Hyaluronic Acid ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Hyaluronic Acid Hydrogel

scholarly journals Design of cell–matrix interactions in hyaluronic acid hydrogel scaffolds

2014 ◽  
Vol 10 (4) ◽  
pp. 1571-1580 ◽  
Author(s):  
Jonathan Lam ◽  
Norman F. Truong ◽  
Tatiana Segura
Keyword(s):  
Hyaluronic Acid ◽  
Hydrogel Scaffolds ◽  
Cell Matrix ◽  
Matrix Interactions ◽  
Cell Matrix Interactions ◽  
Hyaluronic Acid Hydrogel

A novel one-step mechanically strengthened hyaluronic acid hydrogel assisted by a small molecular agent

2021 ◽  
Author(s):  
Shan Yu ◽  
Zhiwen Zeng ◽  
Cuiping Guo ◽  
Jiu Jiang ◽  
Dating Pei ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
One Step ◽  
Hyaluronic Acid Hydrogel
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