A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery

2009 ◽  
Vol 134 (3) ◽  
pp. 207-213 ◽  
Author(s):  
Xu-Li Wang ◽  
Rongzuo Xu ◽  
Zheng-Rong Lu
Keyword(s):  
Cell Membrane ◽  
Delivery System ◽  
Targeted Delivery ◽  
Sirna Delivery ◽  
Ph Sensitive ◽  
Membrane Disruption ◽  
Cell Membrane Disruption ◽  
Targeted Delivery System

Cell membrane-coated nanocarriers: the emerging targeted delivery system for cancer theranostics

2018 ◽  
Vol 23 (4) ◽  
pp. 891-899 ◽  
Author(s):  
Rajendran JC Bose ◽  
Ramasamy Paulmurugan ◽  
James Moon ◽  
Soo-Hong Lee ◽  
Hansoo Park
Keyword(s):  
Cell Membrane ◽  
Delivery System ◽  
Targeted Delivery ◽  
Cancer Theranostics ◽  
Targeted Delivery System

Targeted Delivery of siRNA Therapeutics using Ligand Mediated Biodegradable Polymeric Nanocarriers

2018 ◽  
Vol 24 (16) ◽  
pp. 1788-1800 ◽  
Author(s):  
Kye-Soo Cho ◽  
Seo-Jin Hong ◽  
Min-Hye Ahn ◽  
Sukdeb Pal ◽  
Pill-Hoon Choung ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Delivery System ◽  
Targeted Delivery ◽  
Sirna Delivery ◽  
Public Health Issue ◽  
Magic Bullet ◽  
Bodily Fluids ◽  
Low Cytotoxicity ◽  
Genetic And Environmental Factors ◽  
Sirna Delivery System

Background: Cancer poses a major public health issue, is linked with high mortality rates across the world, and shows a strong interplay between genetic and environmental factors. To date, common therapeutics, including chemotherapy, immunotherapy, and radiotherapy, have made significant contributions to cancer treatment, although diverse obstacles for achieving the permanent “magic bullet” cure have remained. Recently, various anticancer therapeutic agents designed to overcome the limitations of these conventional cancer treatments have received considerable attention. One of these promising and novel agents is the siRNA delivery system; however, poor cellular uptake and altered siRNA stability in physiological environments have limited its use in clinical trials. Therefore, developing the ideal siRNA delivery system with low cytotoxicity, improved siRNA stability in the body’s circulation, and prevention of its rapid clearance from bodily fluids, is rapidly emerging as an innovative therapeutic strategy to combat cancer. Moreover, active targeting using ligand moieties which bind to over-expressed receptors on the surface of cancer cells would enhance the therapeutic efficiency of siRNA. Conclusion: In this review, we provide 1) an overview of the non-viral carrier associated with siRNA delivery for cancer treatment, and 2) a description of the five major cancer-targeting ligands.

Targeted delivery system using silica nanoparticles coated with chitosan and AS1411 for combination therapy of doxorubicin and antimiR-21

2021 ◽  
pp. 118111
Author(s):  
Fatemeh Khatami ◽  
Maryam M. Matin ◽  
Noor Mohammad Danesh ◽  
Ahmad Reza Bahrami ◽  
Khalil Abnous ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Silica Nanoparticles ◽  
Delivery System ◽  
Targeted Delivery ◽  
Targeted Delivery System

Targeted Delivery System Based on Gemcitabine-Loaded Silk Fibroin Nanoparticles for Lung Cancer Therapy

2017 ◽  
Vol 9 (37) ◽  
pp. 31600-31611 ◽  
Author(s):  
Fatemeh Mottaghitalab ◽  
Melika Kiani ◽  
Mehdi Farokhi ◽  
Subhas C. Kundu ◽  
Rui L. Reis ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Silk Fibroin ◽  
Delivery System ◽  
Targeted Delivery ◽  
Silk Fibroin Nanoparticles ◽  
Lung Cancer Therapy ◽  
Targeted Delivery System

Melanoma-targeted delivery system (part 1): Design, synthesis and evaluation of releasable disulfide drug by glutathione

2015 ◽  
Vol 101 ◽  
pp. 668-680 ◽  
Author(s):  
Radhia El Aissi ◽  
Jean-Michel Chezal ◽  
Sébastien Tarrit ◽  
Olivier Chavignon ◽  
Emmanuel Moreau
Keyword(s):  
Delivery System ◽  
Targeted Delivery ◽  
Design Synthesis ◽  
System Part ◽  
Targeted Delivery System
Sign in / Sign up

Export Citation Format

Share Document