Use of cobalt blue light in grading cataract and estimating vision loss

Background. Droplet simulation often requires expensive and inaccessible equipment. Herein, we develop and assess a low-cost droplet simulation model using easily accessible materials, open-source software, and a smartphone-based cobalt blue light. Methods. The simulation model was developed using commercial-grade materials and fluorescein dye. A clear face shield was assessed ten times following a simulated cough using fluorescein dye. A conventional ultraviolet Woods lamp was compared to a smartphone-based cobalt blue light to detect fluorescein illumination. Results. The simulation platform and smartphone-based cobalt blue light cost $20.18. A Wilcoxon signed rank test revealed that the median droplet area of fluorescence under the UV Wood’s lamp was not significantly different than that of the smartphone-based cobalt blue light (2.89 vs 2.94, P = .386). Conclusions. This simulation model is inexpensive and easily reproducible. The smartphone application may be a convenient alternative to standard ultraviolet lights. This model has great potential for use in financially restricted academic centers during the COVID-19 pandemic and beyond.

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Expression of Pro-Angiogenic Markers Is Enhanced by Blue Light in Human RPE Cells

Antioxidants ◽

10.3390/antiox9111154 ◽

2020 ◽

Vol 9 (11) ◽

pp. 1154 ◽

Cited By ~ 4

Author(s):

Concetta Scimone ◽

Simona Alibrandi ◽

Sergio Zaccaria Scalinci ◽

Edoardo Trovato Battagliola ◽

Rosalia D’Angelo ◽

...

Keyword(s):

Blue Light ◽

Vision Loss ◽

Pigment Epithelium ◽

Retinal Pigment ◽

R Package ◽

Rpe Cells ◽

Inherited Retinal Dystrophies ◽

Retinal Dystrophies ◽

Increased Risk ◽

Angiogenic Markers

Inherited retinal dystrophies are characterized by photoreceptor death. Oxidative stress usually occurs, increasing vision loss, and oxidative damage is often reported in retinitis pigmentosa (RP). More than 300 genes have been reported as RP causing. In contrast, choroidal neovascularization (CNV) only occasionally develops in the late stages of RP. We herein study the regulation of RP causative genes that are likely linked to CNV onset under oxidative conditions. We studied how the endogenous adduct N-retinylidene-N-retinylethanolamine (A2E) affects the expression of angiogenic markers in human retinal pigment epithelium (H-RPE) cells and a possible correlation with RP-causing genes. H-RPE cells were exposed to A2E and blue light for 3 and 6h. By transcriptome analysis, genes differentially expressed between A2E-treated cells and untreated ones were detected. The quantification of differential gene expression was performed by the Limma R package. Enrichment pathway analysis by the FunRich tool and gene prioritization by ToppGene allowed us to identify dysregulated genes involved in angiogenesis and linked to RP development. Two RP causative genes, AHR and ROM1, can be associated with an increased risk of CNV development. Genetic analysis of RP patients affected by CNV will confirm this hypothesis.

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Comparison of scotopic pupil measurement with slitlamp-based cobalt blue light and infrared video-based system

Journal of Cataract & Refractive Surgery ◽

10.1016/s0886-3350(02)01383-4 ◽

2002 ◽

Vol 28 (11) ◽

pp. 1952-1956 ◽

Cited By ~ 11

Author(s):

Tomy Starck ◽

Yun Liu ◽

Amy L. Prewett ◽

Lettie G. Curup

Keyword(s):

Blue Light ◽

Infrared Video ◽

Cobalt Blue

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Manufacturing Multicolor LED-Based Phototherapy Device with a Novel 3D Design

Journal of Intelligent Systems with Applications ◽

10.54856/jiswa.202112174 ◽

2021 ◽

pp. 120-124

Author(s):

Busra Yasar ◽

Yalcin Isler ◽

Nermin Topaloglu Avsar

Keyword(s):

Light Intensity ◽

Brain Damage ◽

Blue Light ◽

High Voltage ◽

Automatic System ◽

Vision Loss ◽

Target Area ◽

Kidney Dysfunction ◽

3D Design ◽

Lung And Kidney

Jaundice is a condition that results from an increase in bilirubin level in the blood. Its prevalence in newborns is around 60-70%. When this temporary jaundice becomes pathological and left untreated, significant damages may occur such as brain damage, vision loss, lung and kidney dysfunction, and even death. One of the methods used for the treatment of jaundice is phototherapy. In this study, a design has been made with 3 foldable LED panels to increase the target area. In addition, high-voltage LEDs with blue-green white wavelengths were used. Thus, it was aimed to minimize the risks of nausea and dizziness caused by intense blue light. An automatic system has been achieved by using temperature and light intensity sensors. The system will warn the user at temperatures and light intensity that are harmful to the baby.

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Can we measure mesopic pupil size with the cobalt blue light slit-lamp biomicroscopy method?

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-011-1909-0 ◽

2012 ◽

Vol 250 (11) ◽

pp. 1637-1647 ◽

Cited By ~ 2

Author(s):

Miguel J. Maldonado ◽

Alberto López-Miguel ◽

David P. Piñero ◽

José R. Juberías ◽

Juan C. Nieto ◽

...

Keyword(s):

Blue Light ◽

Pupil Size ◽

Slit Lamp ◽

Slit Lamp Biomicroscopy ◽

Cobalt Blue

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Cobalt blue light unit filter - A smartphone attachment for blue light photography

Indian Journal of Ophthalmology ◽

10.4103/ijo.ijo_3697_20 ◽

2021 ◽

Vol 69 (10) ◽

pp. 2841

Author(s):

AthulS Puthalath ◽

Neeti Gupta ◽

Ramanuj Samanta ◽

Anupam Singh ◽

Devesh Kumawat ◽

...

Keyword(s):

Blue Light ◽

Cobalt Blue

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Plasma Rich in Growth Factors Promotes Autophagy in ARPE19 Cells in Response to Oxidative Stress Induced by Blue Light

Biomolecules ◽

10.3390/biom11070954 ◽

2021 ◽

Vol 11 (7) ◽

pp. 954

Author(s):

Carlota Suárez-Barrio ◽

Susana del Olmo-Aguado ◽

Eva García-Pérez ◽

Luis Fernández-Vega-Cueto ◽

Andrés Fernández-Vega Cueto ◽

...

Keyword(s):

Oxidative Stress ◽

Growth Factors ◽

Blue Light ◽

Vision Loss ◽

Age Related Macular Degeneration ◽

Response To Treatment ◽

Retinal Cell ◽

Cell Renewal ◽

Age Related ◽

Cellular Components

Age-related macular degeneration (AMD) causes the degeneration of photoreceptors and retinal cells leading to vision loss in older subjects. Among possible exogenous risk factors, it has been recently proposed that long-term exposure to blue light could aggravate the course of AMD. In the search for therapeutic options, plasma rich in growth factors (PRGF) has been shown to enhance cell antioxidant pathways and protect photoreceptors against the harm produced by blue light, although its mechanism of action remains unknown. One possible mechanism, autophagy, is one of the most conservative cell renewal systems used in eukaryotes to destroy cellular components that have been damaged by some kind of insult. The oxidative stress of exposure to blue light is known to induce cell autophagy. In this study, we examined the combined effects on autophagy of blue light and PRGF in a retinal cell line, ARPE19. In response to treatment with both PRGF and blue light, we detected the modulated expression of autophagy markers such as NF-kB, p62/sqstm1, Atg5, LC3 and Beclin1, and inflammatory markers such as IL1B and IL18. Our findings suggest that PRGF promotes cell autophagy in response to exposure to blue light.

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