Corrigendum to “Proteome-wide changes in primary skin keratinocytes exposed to diesel particulate extract – A role for antioxidants in skin health” [J. Dermatol. Sci. 91 (3) (2018) 239–249]

2019 ◽  
Vol 96 (2) ◽  
pp. 113
Keyword(s):  
Diesel Particulate ◽  
Skin Keratinocytes ◽  
Diesel Particulate Extract

scholarly journals Proteome-wide changes in primary skin keratinocytes exposed to diesel particulate extract—A role for antioxidants in skin health

2018 ◽  
Vol 91 (3) ◽  
pp. 239-249 ◽  
Author(s):  
Pavithra Rajagopalan ◽  
Ankit P. Jain ◽  
Vishalakshi Nanjappa ◽  
Krishna Patel ◽  
Kiran K. Mangalaparthi ◽  
...  
Keyword(s):  
Diesel Particulate ◽  
Skin Keratinocytes ◽  
Diesel Particulate Extract

scholarly journals Proteome-wide changes in primary skin keratinocytes exposed to diesel particulate extract—A role for antioxidants in skin health

2019 ◽  
Vol 96 (2) ◽  
pp. 114-124 ◽  
Author(s):  
Pavithra Rajagopalan ◽  
Ankit P. Jain ◽  
Vishalakshi Nanjappa ◽  
Krishna Patel ◽  
Kiran K. Mangalaparthi ◽  
...  
Keyword(s):  
Diesel Particulate ◽  
Skin Keratinocytes ◽  
Diesel Particulate Extract

scholarly journals NADPH Oxidase-Mediated Activation of Neutral Sphingomyelinase Is Responsible for Diesel Particulate Extract-Induced Keratinocyte Apoptosis

2020 ◽  
Vol 21 (3) ◽  
pp. 1001 ◽  
Author(s):  
Hyun-Seok Lee ◽  
Hye Yoon Park ◽  
Sung Pil Kwon ◽  
Bogyeong Kim ◽  
Yerin Lee ◽  
...  
Keyword(s):  
Cell Fate ◽  
Air Pollutants ◽  
Specific Inhibitor ◽  
Ros Generation ◽  
Cellular Functions ◽  
Diesel Particulate ◽  
Neutral Sphingomyelinase ◽  
Sphingosine 1 Phosphate ◽  
Pre Treatment ◽  
Diesel Particulate Extract

Human epidermis is positioned at the interface with the external environment, protecting our bodies against external challenges, including air pollutants. Emerging evidence suggests that diesel particulate extract (DPE), a major component of air pollution, leads to impairment of diverse cellular functions in keratinocytes (KC). In this study, we investigated the cellular mechanism underlying DPE-induced KC apoptosis. We first addressed cell death occurring in KC exposed to DPE, paralleled by increased activation of NADPH oxidases (NOXs) and subsequent ROS generation. Blockade of NOX activation with a specific inhibitor attenuated the expected DPE-induced KC apoptosis. In contrast, pre-treatment with a specific inhibitor of reactive oxygen species (ROS) generation did not reverse DPE/NOX-mediated increase in KC apoptosis. We next noted that NOX-mediated KC apoptosis is mainly attributable to neutral sphingomyelinase (SMase)-mediated stimulation of ceramides, which is a well-known pro-apoptotic lipid. Moreover, we found that inhibition of NOX activation significantly attenuated DPE-mediated increase in the ratio of ceramide to its key metabolite sphingosine-1-phosphate (S1P), an important determinant of cell fate. Together, these results suggest that activation of neutral SMase serves as a key downstream signal for the DPE/NOX activation-mediated alteration in ceramide and S1P productions, and subsequent KC apoptosis.

scholarly journals Activated Toxicity of Diesel Particulate Extract by Ultraviolet A Radiation in Mammalian Cells: Role of Singlet Oxygen

2009 ◽  
Vol 117 (3) ◽  
pp. 436-441 ◽  
Author(s):  
Lingzhi Bao ◽  
An Xu ◽  
Liping Tong ◽  
Shaopeng Chen ◽  
Lingyan Zhu ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Mammalian Cells ◽  
Ultraviolet A ◽  
Diesel Particulate ◽  
Diesel Particulate Extract

The Morphology and Crystallography of Diesel Particulate Emissions

1981 ◽  
Vol 39 ◽  
pp. 148-149
Author(s):  
R. Stevenson
Keyword(s):  
Diffraction Pattern ◽  
Carbon Films ◽  
Particulate Emissions ◽  
Diesel Particulate ◽  
Amorphous Carbon Films ◽  
Turbostratic Carbon ◽  
Diesel Particles ◽  
Tem Mode ◽  
Exhaust Stream ◽  
Diffraction Patterns

A study has been made of the morphology and crystallography of particulate emissions from indirect injection diesel engines. This particulate matter consists substantially of carbon (although hydrocarbons can be extracted with solvents). Samples were collected in a diluted exhaust stream on amorphous carbon films and examined in a JEM-200C electron microscope operated in the TEM mode with an accelerating voltage of 200 KV.The morphology of the diesel particles, as shown in Fig. 1, markedly resembles carbon blacks and consists of an agglomeration of quasispherical subunits arranged in chains or clusters. Only limited changes in morphology were observed as the number of subunits in the particle increased (although larger particles tended to be more cluster-like than the extended chain shown in Fig. 1). However, a dramatic effect of the number of subunits was observed on the character of the diffraction pattern. Smaller particles yielded a diffraction pattern consisting of very diffuse rings typical of turbostratic carbon; the diffraction patterns from the larger particles, however, although qualitatively similar, exhibited much sharper and less diffuse ring patterns.

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