The effect of hemodialysis on accelerated atherosclerosis in diabetic patients: correlation of carotid artery intima-media thickness with oxidative stress

2009 ◽  
Vol 23 (4) ◽  
pp. 257-264 ◽  
Author(s):  
Belda Dursun ◽  
Evrim Dursun ◽  
Gultekin Suleymanlar ◽  
Beste Ozben ◽  
Irfan Capraz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carotid Artery ◽  
Intima Media Thickness ◽  
Diabetic Patients ◽  
Accelerated Atherosclerosis ◽  
Media Thickness

Are Uremia, Diabetes, and Atherosclerosis Linked With Impaired Antioxidant Mechanisms?

2008 ◽  
Vol 56 (2) ◽  
pp. 545-552 ◽  
Author(s):  
Belda Dursun ◽  
Evrim Dursun ◽  
Irfan Capraz ◽  
Tomris Ozben ◽  
Ali Apaydin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intima Media Thickness ◽  
Chronic Kidney Failure ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Carotid Imt ◽  
Accelerated Atherosclerosis ◽  
Media Thickness ◽  
Diabetes Status ◽  
Antioxidant Mechanisms

BackgroundOxidative stress is a new risk factor for atherosclerosis. Increased oxidative stress in hemodialysis (HD) patients may arise from uremia-associated metabolic/humoral abnormalities and bioincompatibility of dialysis. Patients with diabetes mellitus (DM) may be subject to an additional risk. Respective influences of uremia, diabetes, and HD duration in accelerated atherosclerosis and oxidative stress have not been clarified yet.MethodsThe study was performed on 24 nondiabetic HD patients, 23 diabetic HD patients, 20 stages 3 to 4 chronic kidney disease patients, and 21 diabetic patients without overt nephropathy. Carotid intima-media thickness, a surrogate of atherosclerosis, was measured by high-resolution B-mode ultrasonography. Oxidant status was determined by lipid peroxidation as expressed by malondialdehyde (MDA); antioxidant status was determined by superoxide dismutase, catalase, glutathione peroxidase, reduced intracellular glutathione, and plasma thiol.ResultsIntima-media thickness (IMT) was higher in patients undergoing HD but not different between nondiabetic HD patients and diabetic HD patients. No correlation was found between the duration of HD and intima-media thickness. Antioxidants were generally lower in HD patients. Intima-media thickness was positively correlated with MDA and negatively correlated with plasma thiol. Among other risk factors, only age was correlated with intima-media thickness.ConclusionsIncreased carotid IMT in HD patients is independent of duration of HD or diabetes status. Age and MDA are the significant predictors of carotid IMT. Increased oxidative stress due to impaired antioxidant mechanisms, particularly reduced plasma thiol redox potential, may account for accelerated atherosclerosis in high-risk patients with chronic kidney failure and/or DM.

THE EFFECT OF OXIDATIVE STRESS ON CAROTID ARTERY INTIMA-MEDIA THICKNESS IN DIABETIC PATIENTS

2008 ◽  
Vol 9 (1) ◽  
pp. 73
Author(s):  
E. Dursun ◽  
B. Dursun ◽  
G. Suleymanlar ◽  
B. Ozben ◽  
I. Capraz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carotid Artery ◽  
Intima Media Thickness ◽  
Diabetic Patients ◽  
Media Thickness

scholarly journals Coronary Artery Disease and Carotid Artery Intima-Media Thickness in Japanese Type 2 Diabetic Patients

Diabetes Care ◽  
2002 ◽  
Vol 25 (8) ◽  
pp. 1308-1312 ◽  
Author(s):  
N. Mitsuhashi ◽  
T. Onuma ◽  
S. Kubo ◽  
N. Takayanagi ◽  
M. Honda ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Carotid Artery ◽  
Intima Media Thickness ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Media Thickness ◽  
Artery Disease ◽  
Type 2 Diabetic

scholarly journals Common Carotid Artery Intima-Media Thickness Reflects the Cumulative Burden of Atherosclerosis and Predicted Well by Total-C/HDL-C Ratio in Type-II Diabetic Patients- A Case Control Study Based from Kolkata, India

2013 ◽  
Vol 5 (1) ◽  
pp. 9-14
Author(s):  
Tanmay Jyoti Sau ◽  
Sandip Kumar Dey ◽  
Arun Kumar ◽  
Utpal Kumar Biswas
Keyword(s):  
Carotid Artery ◽  
Common Carotid Artery ◽  
Case Control Study ◽  
Intima Media Thickness ◽  
Case Control ◽  
Diabetic Patients ◽  
Type Ii ◽  
Medical College ◽  
Media Thickness ◽  
Control Study

Background: Diabetes Mellitus (DM) is frequently associated with the development of premature atherosclerotic vascular disease and is the major cause of morbidity and mortality. Approximately 80% of all deaths and more than 75% of all hospitalizations are due to CAD. Individuals with DM are usually associated with accelerated atherosclerosis. Common Carotid artery intima-media thickness (CCAIMT) is now also considered as a surrogate marker of atherosclerosis. Materials and Methods: This case-control study was conducted from Jan, 2011 to June, 2012 among Type-II diabetes, aged between 30-80yrs. Patients with Type-I diabetes, aged <30yrs or >80yrs and other secondary causes of diabetes, hypertensive, smokers and patients under therapy with lipid lowering drugs were excluded from this study. The biochemical tests were done in the department of Biochemistry, Nilratan Sarkar Medical College and Hospital, using standardized reagent kits. CCAIMT was measured by high resolution imaging using 10MHz transducer in the department of Radiodiagnosis, Nilratan Sarkar Medical College and Hospital. Results: The results of our study indicate that dyslipidemic diabetic patients had significantly higher blood glucose at any phase along with glycated haemoglobin compared to controls. The lipid variables were also significantly higher in the diabetes patients with dyslipidemia compared to controls except HDL levels were significantly higher in control. CCAIMT was higher in the dyslipidemic group (1.71 ± 0.57mm) compared to the non-dyslipidemic group (0.77 ± 0.10) which was statistically significant (p value <0.001). Conclusion: CCAIMT reflects the cumulative burden of atherosclerosis and is highly correlated and predicted well by Total-C/HDL-C ratio in Type-II diabetic patients. So it is advised that a direct examination of the vessel wall is extremely essential for early detection of the affected individuals so that the cost burden in Intensive coronary care unit can be minimized and also the individual can be advised to control the extensive dyslipidemia through dietary restrictions and exercise. DOI: http://dx.doi.org/10.3126/ajms.v5i1.8450 Asian Journal of Medical Science Vol.5(1) 2014 pp.9-14

Contribution of Distensibility and Intima-Media Thickness to the Etiology of Stroke

2005 ◽  
Vol 18 (1) ◽  
pp. 78-81
Author(s):  
J. Chlumský ◽  
J. Charvát
Keyword(s):  
Atrial Fibrillation ◽  
Carotid Artery ◽  
Type Ii Diabetes ◽  
Intima Media Thickness ◽  
Diabetic Patients ◽  
Type Ii ◽  
Stroke Patients ◽  
Media Thickness ◽  
Atrial Fibrilation

We evaluated carotid artery distensibility (D) and intima-media thickness (IMT) in patients with stroke (S), and its relationship to diabetes and atrial fibrilation. We measured D and IMT in 89 stroke patients. 59 patients had type II diabetes and 64 patients had atrial fibrillation. D was determined using the Reneman formula (mm/100mm Hg). D was consistently lower in diabetic patients then in non-diabetic patients (0.14 v. 0.17, p=0.039) and showed a relation to IMT. In atrial fibrillation patients IMT was consistently lower (67 v.79 mm, p=0.033) and D was increased (0.19 v. 0.10, p=0.023). Type II diabetes is characterized by wall stiffening and thickening of the carotid artery. D and IMT can contribute to the differentiation of embolic and thrombotic etiology of stroke.

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