Are Uremia, Diabetes, and Atherosclerosis Linked With Impaired Antioxidant Mechanisms?

2008 ◽  
Vol 56 (2) ◽  
pp. 545-552 ◽  
Author(s):  
Belda Dursun ◽  
Evrim Dursun ◽  
Irfan Capraz ◽  
Tomris Ozben ◽  
Ali Apaydin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intima Media Thickness ◽  
Chronic Kidney Failure ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Carotid Imt ◽  
Accelerated Atherosclerosis ◽  
Media Thickness ◽  
Diabetes Status ◽  
Antioxidant Mechanisms

BackgroundOxidative stress is a new risk factor for atherosclerosis. Increased oxidative stress in hemodialysis (HD) patients may arise from uremia-associated metabolic/humoral abnormalities and bioincompatibility of dialysis. Patients with diabetes mellitus (DM) may be subject to an additional risk. Respective influences of uremia, diabetes, and HD duration in accelerated atherosclerosis and oxidative stress have not been clarified yet.MethodsThe study was performed on 24 nondiabetic HD patients, 23 diabetic HD patients, 20 stages 3 to 4 chronic kidney disease patients, and 21 diabetic patients without overt nephropathy. Carotid intima-media thickness, a surrogate of atherosclerosis, was measured by high-resolution B-mode ultrasonography. Oxidant status was determined by lipid peroxidation as expressed by malondialdehyde (MDA); antioxidant status was determined by superoxide dismutase, catalase, glutathione peroxidase, reduced intracellular glutathione, and plasma thiol.ResultsIntima-media thickness (IMT) was higher in patients undergoing HD but not different between nondiabetic HD patients and diabetic HD patients. No correlation was found between the duration of HD and intima-media thickness. Antioxidants were generally lower in HD patients. Intima-media thickness was positively correlated with MDA and negatively correlated with plasma thiol. Among other risk factors, only age was correlated with intima-media thickness.ConclusionsIncreased carotid IMT in HD patients is independent of duration of HD or diabetes status. Age and MDA are the significant predictors of carotid IMT. Increased oxidative stress due to impaired antioxidant mechanisms, particularly reduced plasma thiol redox potential, may account for accelerated atherosclerosis in high-risk patients with chronic kidney failure and/or DM.

scholarly journals Relationships between Serum Uric Acid, Malondialdehyde Levels, and Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Shun-Sheng Wu ◽  
Chew-Teng Kor ◽  
Ting-Yu Chen ◽  
Ko-Hung Liu ◽  
Kai-Lun Shih ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Serum Markers ◽  
Oxidative Stress Biomarkers ◽  
Cross Sectional ◽  
Carotid Imt ◽  
Media Thickness

Oxidative stress is the major cause of atherosclerosis and cardiovascular diseases. This cross-sectional study is aimed at determining if parallel serum markers of oxidative stress are related to carotid intima-media thickness (IMT). We enrolled 134 participants with varied metabolic syndrome (Met-S) scores (zero, n=21; one, n=19; two, n=27; three, n=26; four, n=25; five, n=16). Biochemical profiles and potential oxidative stress biomarkers malondialdehyde (MDA) and uric acid were measured in fasting plasma. We found that carotid IMT positively correlated with both MDA and uric acid levels. Multivariate analysis revealed that both MDA (p<0.05) and uric acid (p<0.01) levels were significantly associated with carotid IMT in participants whose Met-S scores were ≥1 or ≥2. However, only uric acid (p<0.01) levels were positively associated with carotid IMT in patients with metabolic syndrome. Linear regression model analysis revealed that the prediction accuracies for carotid IMT from MDA combined with uric acid and from a combination of MDA, uric acid, and Met-S score were 0.176 and 0.237, respectively. These were better than the predication accuracies from MDA (r2=0.075) and uric acid (r2=0.148) individually. These results suggest that measuring uric acid levels along with MDA biomarkers and Met-S scores may be a promising step in the development of an effective model for monitoring the severity of carotid IMT and atherosclerosis in the patients with metabolic syndrome.

scholarly journals Association of Catalase Gene rs769217 Polymorphism with Carotid Intima-media Thickness in Diabetic Patients

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Catalase Gene ◽  
Media Thickness ◽  
New Finding

Diabetes mellitus is a risk factor for atherosclerosis/cardiovascular diseases. Atherosclerosis in diabetic patients has been linked to increased oxidative stress and intima-media thickness is used to detect its presence. Catalase is involved in hydrogen peroxide catabolism and is important in defense against oxidative stress, which contributes significantly to atherosclerotic processes. There are no data on association of catalase gene genotypes of rs769217 polymorphism and carotid artery intima-media thickness. Therefore, this study investigated the potential association of catalase rs769217 polymorphism and intima media thickness in diabetic patients. Right and left carotid intima-media thickness increased (P≤0.001) in type 1 and type 2 diabetes when it was compared to those of controls. Blood catalase activities of CC genotypes of rs769217 polymorphism in catalase gene were associated with cITT (P<0.043) in type 1 diabetics, type 2 diabetics and in controls. This interesting new finding could suggest that diabetics and controls with CC genotype of rs769217 polymorphism may have higher carotid intima media thickness and higher risks for cardiovascular events when they blood catalase is high. This higher catalase could destroy hydrogen peroxide more effectively thus preventing the signaling action of hydrogen peroxide.

scholarly journals Carotid intima-media thickness and arterial stiffness in type 1 diabetic patients with and without microangiopathy

2012 ◽  
Vol 3 ◽  
pp. 484-490 ◽  
Author(s):  
Anita Rogowicz-Frontczak ◽  
Aleksandra Araszkiewicz ◽  
Stanislaw Pilacinski ◽  
Dorota Zozulinska-Ziolkiewicz ◽  
Andrzej Wykretowicz ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Media Thickness ◽  
Type 1 Diabetic Patients

Endothelial Dysfunction, Carotid Intima-Media Thickness, and Accelerated Atherosclerosis in Rheumatoid Arthritis

2008 ◽  
Vol 38 (2) ◽  
pp. 67-70 ◽  
Author(s):  
Miguel A. Gonzalez-Gay ◽  
Carlos Gonzalez-Juanatey ◽  
Tomas R. Vazquez-Rodriguez ◽  
Javier Martin ◽  
Javier Llorca
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Accelerated Atherosclerosis ◽  
Media Thickness

Correlation between Levels of Circulating Adipokines and Adiponectin/Resistin Index with Carotid Intima-Media Thickness in Hypertensive Type 2 Diabetic Patients

Cardiology ◽  
2013 ◽  
Vol 125 (3) ◽  
pp. 150-153 ◽  
Author(s):  
Alberto F. Rubio-Guerra ◽  
Luis J. Cabrera-Miranda ◽  
Hilda Vargas-Robles ◽  
Alberto Maceda-Serrano ◽  
José J. Lozano-Nuevo ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Media Thickness ◽  
Type 2 Diabetic

Abstract P218: Carotid Intima-media Thickness and Incident End-stage Renal Disease: The Atherosclerosis Risk in Communities Study

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Yuanjie Pang ◽  
Yingying Sang ◽  
Shoshana Ballew ◽  
Morgan Grams ◽  
Gerardo Heiss ◽  
...  
Keyword(s):  
Renal Disease ◽  
Kidney Function ◽  
End Stage Renal Disease ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Carotid Imt ◽  
Media Thickness ◽  
Hazard Ratios ◽  
Stage Renal Disease ◽  
End Stage

Introduction: Carotid intima-media thickness (IMT) has been reported to predict kidney function decline. However, whether carotid IMT is associated with a hard kidney endpoint, end-stage renal disease (ESRD), has not been investigated. Hypothesis: We assessed the hypothesis that increased carotid IMT is associated with ESRD risk. Methods: We studied 13,197 ARIC participants at visit 1 (1987-1989) without history of cardiovascular disease including coronary heart disease, stroke and heart failure and assessed whether carotid IMT measured by B-mode ultrasound is associated with ESRD risk using Cox proportional-hazards models. Regarding carotid IMT parameters, we investigated the mean and maximum values of overall and segment-specific (common, bifurcation and internal carotid arteries) measurements. Results: Mean age was 54.0 (SD 5.7) years, and there were 3,373 (25.6%) blacks and 7,370 (55.8%) women. During a median follow-up of 22.7 years, 433 participants developed ESRD (1.4/1,000 person-years). After adjusting for shared risk factors for atherosclerosis and kidney disease, including baseline kidney function, carotid IMT was significantly associated with ESRD risk (hazard ratios between quartiles 4 and 1, 1.43 [95%CI: 1.01-2.04] for overall mean IMT and 1.73 [95%CI: 1.22-2.44] for overall maximum IMT). The associations were largely consistent in demographic and clinical subgroups. When we explored segment-specific IMTs, the associations with ESRD were most robust for bifurcation carotid. The adjusted hazard ratios between quartiles 4 and 1 were 1.48 (95%CI: 1.04-2.11) for mean bifurcation IMT and 1.42 (95%CI: 0.99-2.03) for maximum bifurcation IMT. Conclusions: Carotid IMT was independently associated with incident ESRD in the general population. Our findings suggest the shared etiology between atherosclerosis and ESRD and highlight the importance of monitoring kidney function over time in individuals with subclinical atherosclerosis.

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