scholarly journals Application of regenerative medicine to salivary gland hypofunction

2021 ◽  
Vol 57 ◽  
pp. 54-59
Author(s):  
Junichi Tanaka ◽  
Kenji Mishima
Keyword(s):  
Salivary Gland ◽  
Regenerative Medicine ◽  
Salivary Gland Hypofunction

scholarly journals Older age, smoking, tooth loss and denture-wearing but neither xerostomia nor salivary gland hypofunction are associated with low intakes of fruit and vegetables in older Danish adults

2021 ◽  
Vol 10 ◽  
Author(s):  
Anne Marie Lynge Pedersen ◽  
Anja Weirsøe Dynesen ◽  
Berit Lilienthal Heitmann
Keyword(s):  
Salivary Gland ◽  
Tooth Loss ◽  
Vegetable Intake ◽  
Community Dwelling ◽  
Older Age ◽  
Fruit And Vegetables ◽  
Fruit And Vegetable ◽  
Flow Rates ◽  
Whole Saliva ◽  
Salivary Gland Hypofunction

Abstract Xerostomia and salivary gland hypofunction are prevalent conditions in older people and may adversely influence the intake of certain foods, notably fruit and vegetables. Here, we aimed to investigate whether xerostomia and salivary gland hypofunction were associated with a lower intake of fruit and vegetables. The study included 621 community-dwelling adults, mean age 75⋅2 ± 6⋅4 years, 58⋅9 % female, who had participated in the Copenhagen City Heart Study follow-up, and undergone interviews regarding food intake (preceding month), oral and general health (xerostomia, taste alterations, diseases, medication, alcohol consumption and smoking), clinical oral examination and measurements of unstimulated and chewing-stimulated whole saliva flow rates. The average total energy intake (8⋅4 ± 2⋅7 MJ) and protein energy percentage (14⋅8 ± 3⋅1 %) were slightly below recommendations. The average fruit (234⋅7 ± 201⋅2 g/d) and vegetables (317⋅3 ± 157⋅4 g/d) intakes were within recommendations. Xerostomia and hyposalivation were more prevalent in women than in men (16⋅4 v. 7⋅1 %, P < 0⋅001 and 40⋅7 v. 27⋅5 %, P < 0⋅001). Multiple linear regression analyses revealed that older age (β −0⋅009, se 0⋅003, P = 0⋅005), smoking (β −0⋅212, se 0⋅060, P = 0⋅0005) and wearing complete dentures/being partially or fully edentulous (β −0⋅141, se 0⋅048, P = 0⋅003), but neither xerostomia nor salivary flow rates were associated with an inadequate fruit and vegetable intake, after adjustment for covariates. Older age, smoking, tooth loss and denture-wearing were stronger determinants of low fruit and vegetable intakes than xerostomia and salivary hypofunction supporting the importance of dietary counselling and maintenance of oral health and an adequate masticatory performance.

scholarly journals Acute salivary gland hypofunction in the duct ligation model in the absence of inflammation

Oral Diseases ◽  
2008 ◽  
Vol 14 (6) ◽  
pp. 520-528 ◽  
Author(s):  
PN Correia ◽  
GH Carpenter ◽  
SM Osailan ◽  
KL Paterson ◽  
GB Proctor
Keyword(s):  
Salivary Gland ◽  
Duct Ligation ◽  
Salivary Gland Hypofunction

Regenerative medicine for end-stage fibrosis and tissue loss in the upper aerodigestive tract: a twenty-first century review

2021 ◽  
pp. 1-13
Author(s):  
F R Green ◽  
N M Shubber ◽  
F S Koumpa ◽  
N J I Hamilton
Keyword(s):  
Salivary Gland ◽  
Regenerative Medicine ◽  
Vocal Fold ◽  
Aerodigestive Tract ◽  
First Century ◽  
Tissue Loss ◽  
Cochrane Library ◽  
Upper Aerodigestive Tract ◽  
Twenty First Century ◽  
End Stage

Abstract Objective This review assesses regenerative medicine of the upper aerodigestive tract during the first two decades of the twenty-first century, focusing on end-stage fibrosis and tissue loss in the upper airways, salivary system, oropharynx and tongue. Method PubMed, Embase, Google Scholar, Cochrane Library, Medline and clinicaltrials.org were searched from 2000 to 2019. The keywords used were: bioengineering, regenerative medicine, tissue engineering, cell therapy, regenerative surgery, upper aerodigestive tract, pharynx, oropharynx, larynx, trachea, vocal cord, tongue and salivary glands. Original studies were subcategorised by anatomical region. Original human reports were further analysed. Articles on periodontology, ear, nose and maxillofacial disorders, and cancer immunotherapy were excluded. Results Of 716 relevant publications, 471 were original studies. There were 18 human studies included, within which 8 reported airway replacements, 5 concerned vocal fold regeneration and 3 concerned salivary gland regeneration. Techniques included cell transplantation, injection of biofactors, bioscaffolding and bioengineered laryngeal structures. Conclusion Moderate experimental success was identified in the restoration of upper airway, vocal fold and salivary gland function. This review suggests that a shift in regenerative medicine research focus is required toward pathology with a higher disease burden.

scholarly journals Salivary Gland Dysfunction in Stroke Patients Is Associated with Increased Protein Glycoxidation and Nitrosative Stress

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Mateusz Maciejczyk ◽  
Piotr Gerreth ◽  
Anna Zalewska ◽  
Katarzyna Hojan ◽  
Karolina Gerreth
Keyword(s):  
Oxidative Stress ◽  
Salivary Gland ◽  
Nitrosative Stress ◽  
Salivary Secretion ◽  
Protein Glycation ◽  
Control Group ◽  
Stroke Patients ◽  
Saliva Secretion ◽  
Whole Saliva ◽  
Salivary Gland Hypofunction

Stroke is one of the leading causes of disability and death worldwide. Despite intensive medical care, many of the complaints directly threatening the patient’s life marginalize their dental needs after the stroke. Recent studies indicate reduced saliva secretion in stroke patients in addition to the increased incidence of caries and periodontal disease. Since oxidative stress plays a vital role in the pathogenesis of salivary gland hypofunction and neurodegenerative disorders (including stroke), this is the first to evaluate the relationship between salivary gland activity and protein glycoxidation and nitrosative damage. The content of glycation and protein oxidation products and nitrosative stress was assessed in nonstimulated (NWS) and stimulated (SWS) whole saliva of stroke patients with normal salivary secretion and hyposalivation (reduced saliva production). The study included 30 patients in the stroke’s subacute phase and 30 healthy controls matched by age and sex. We have shown that stroke patients with hyposalivation show increased contents of protein glycation (↑Amadori products and ↑advanced glycation end products), glycoxidation (↑dityrosine), and nitration (↑nitrotyrosine) products compared to stroke cases with normal salivary secretion and control group. Interestingly, higher oxidative/nitrosative stress was found in NWS, which strongly correlates with salivary flow rate, total protein content, and salivary amylase activity. Such relationships were not observed in the control group. Summarizing, oxidative and nitrosative stress may be one of the mechanisms responsible for the impairment of saliva secretion in stroke patients. However, extraglandular sources of salivary oxidative stress in stroke patients cannot be excluded. Further studies to assess salivary gland hypofunction in stroke cases are necessary.

Oral Signs and Symptoms as Predictors of Salivary Gland Hypofunction in General Dental Practice

2001 ◽  
Vol os8 (3) ◽  
pp. 111-114 ◽  
Author(s):  
E Anne Field ◽  
Lesley P Longman ◽  
Simon Fear ◽  
Susan Higham ◽  
Jocelyne Rostron ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Oral Mucosa ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Dental Practice ◽  
General Dental Practice ◽  
Objective Evidence ◽  
Oral Dryness ◽  
Dental Practices ◽  
Salivary Gland Hypofunction

Objective To evaluate the signs and symptoms of oral dryness as predictors of salivary gland hypofunction (SGH) in general dental practice. Design and setting Prospective study recruiting adult patients attending five general dental practices in Merseyside in 1999. Materials and method Patients were screened for subjective symptoms of oral dysfunction and clinical signs of oral dryness. Patients with oral symptoms or signs of SGH were invited to undergo sialometry. Results were analysed using multiple logistic regression. Results 1103 patients were screened for signs and symptoms of oral dryness, 115 reported continuous xerostomia, of these 65 were also clinically (subjectively) assessed as having a dry oral mucosa. One hundred and one patients attended for sialometry and 73% of these had objective evidence of SGH. Neither the patients’ complaints of oral dryness or the assessment of dryness of the oral mucosa were significant predictors of SGH. Conclusions Symptoms of oral dysfunction and clinical signs of oral dryness were not significant predictors of SGH in dental practice.

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