Geopolitical issues give rise to problems in the smooth and continuous flow of oil and natural gas from the production countries to the consumers’ development countries. In addition, severe environmental issues such as greenhouse gas emissions, eventually guide the consumers to fuels more suitable to the present situation. Alternative fuels such as biogas and coal gas have recently become more attractive because of their benefits, especially for electricity generation. On the other hand, the use of relatively low heating value fuels has a significant effect to the performance parameters of gas turbines. In this paper, the impact of using four fuels with different heating value in the gas turbine performance is simulated. Based on the high efficiency and commercialization criteria, two types of engines are chosen to be simulated: two-shaft simple and single-shaft recuperated cycle gas turbines. The heating values of the four gases investigated, correspond to natural gas and to a series of three gases with gradually lower heating values than that of natural gas. The main conclusions drawn from this design point (DP) and off-design (OD) analysis is that, for a given TET, efficiency increases for both engines when gases with low heating value are used. On the contrary, when power output is kept constant, the use of gases with low heating value will result in a decrease of thermal efficiency. A number of parametric studies are carried out and the effect of operating parameters on performance is assessed. The analysis is performed with customized software, which has been developed for this purpose.