Evaluation of taste masking effect of diclofenac using sweeteners and cyclodextrin by a potentiometric electronic tongue

2016 ◽  
Vol 780 ◽  
pp. 153-159 ◽  
Author(s):  
Joanna Lenik ◽  
Małgorzata Wesoły ◽  
Patrycja Ciosek ◽  
Wojciech Wróblewski
Keyword(s):  
Electronic Tongue ◽  
Masking Effect ◽  
Taste Masking

scholarly journals Characterization and taste masking evaluation of microparticles with cetirizine dihydrochloride and methacrylate-based copolymer obtained by spray drying

2017 ◽  
Vol 67 (1) ◽  
pp. 113-124 ◽  
Author(s):  
Aleksandra Amelian ◽  
Marta Szekalska ◽  
Patrycja Ciosek ◽  
Anna Basa ◽  
Katarzyna Winnicka
Keyword(s):  
Spray Drying ◽  
In Vitro Release ◽  
Electronic Tongue ◽  
Butyl Methacrylate ◽  
Masking Effect ◽  
Taste Masking ◽  
In Vivo Model ◽  
Allergy Treatment

Abstract Taste of a pharmaceutical formulation is an important parameter for the effectiveness of pharmacotherapy. Cetirizine dihydrochloride (CET) is a second-generation antihistamine that is commonly administered in allergy treatment. CET is characterized by extremely bitter taste and it is a great challenge to successfully mask its taste; therefore the goal of this work was to formulate and characterize the microparticles obtained by the spray drying method with CET and poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate 1:2:1 copolymer (Eudragit E PO) as a barrier coating. Assessment of taste masking by the electronic tongue has revealed that designed formulations created an effective taste masking barrier. Taste masking effect was also confirmed by the in vivo model and the in vitro release profile of CET. Obtained data have shown that microparticles with a drug/polymer ratio (0.5:1) are promising CET carriers with efficient taste masking potential and might be further used in designing orodispersible dosage forms with CET.

scholarly journals Utilization of Ethylcellulose Microparticles with Rupatadine Fumarate in Designing Orodispersible Minitablets with Taste Masking Effect

Materials ◽  
2020 ◽  
Vol 13 (12) ◽  
pp. 2715
Author(s):  
Katarzyna Wasilewska ◽  
Patrycja Ciosek-Skibińska ◽  
Joanna Lenik ◽  
Stanko Srčič ◽  
Anna Basa ◽  
...  
Keyword(s):  
Electronic Tongue ◽  
Drug Dissolution ◽  
Masking Effect ◽  
Taste Masking ◽  
Crucial Issue ◽  
Geriatric Population ◽  
Hydrophobic Polymer ◽  
Pharmaceutical Properties

Minitablets in orodispersible form constitute a flexible drug delivery tool for paediatric and geriatric population as they eliminate the risk of chocking and do not require drinking water in the application. Due to their direct contact with taste buds, taste sensation is an important factor. Preparing microparticles with taste masking polymers utilizing spray drying is an efficient technique for reducing the bitterness of drugs. Ethylcellulose is a hydrophobic polymer widely used as a taste masking material. Rupatadine fumarate, one of the newest antihistamines, features an intensive bitter taste, hence in designing orodispersible formulations, achieving an acceptable taste is a crucial issue. The main objective of this work was to formulate orodispersible minitablets containing taste masked ethylcellulose-based microparticles with rupatadine fumarate and evaluation of their quality, especially in terms of taste masking efficacy. The accessed data indicated that all obtained minitablets were characterized by beneficial pharmaceutical properties. Three independent methods: in vivo with healthy volunteers, in vitro drug dissolution, and “electronic tongue” confirmed that all designed formulations provided satisfactory taste masking rate and that formulation F15 (prepared with Pearlitol® Flash and Surelease® microparticles with rupatadine fumarate) was characterized by the lowest bitterness score.

scholarly journals Evaluation of Cytotoxicity and Taste-Masking Effect of Selected Flavors on Dental Lidocaine HCl Injection

2020 ◽  
Vol 13 (11) ◽  
pp. 353
Author(s):  
Sai Boddu ◽  
Diwakar Tukaramrao ◽  
Moawia Al-Tabakha ◽  
Akram Ashames ◽  
Rabin Neupane ◽  
...  
Keyword(s):  
Electronic Tongue ◽  
Masking Effect ◽  
Taste Masking ◽  
Dental Procedures ◽  
Sodium Saccharin ◽  
Ic50 Values ◽  
Lidocaine Hcl ◽  
Dependent Cell ◽  
The Mean ◽  
Dose Dependent

Aim: Anxiety and intolerance to dental local anesthetic injections are common in patients undergoing dental procedures. This work was designed to study cytotoxicity of selected flavors in primary gingival keratinocytes (PGK), to acquire information on their suitability for use in dental lidocaine hydrochloride (LID) injection. We also evaluated the bio-mimetic taste of LID dental injection in the presence of selected flavors and sweetener using an Astree electronic tongue (ETongue). Methods: The cytotoxicity of chocolate natural and artificial flavor (CTE), raspberry flavor artificial (RAS), cherry flavor (CHR), bitterness suppressor flavor (BSF) and lemon flavor extract (LFE) at various dilutions (0.16–10% v/v) was carried out in PGK using the live cell morphological analysis and MTT cell cytotoxicity assay. Based on the cytotoxicity data, CTE and RAS were added to Xylocaine® (2%) along with 0.09% sodium saccharin and taste was assessed using an ETongue. Results: After three hours of treatment, a dose-dependent cell death was induced by all flavors compared to the untreated control. BSF was found to be more toxic when compared to other flavors. CTE was found to be less toxic. The mean IC50 values of CTE, RAS, CHR, BSF and LFE in PGK were found to be 9.54, 8.43, 2.21, 0.38 and 4.01 mg/mL. Taste analysis with the ETongue showed a clear taste difference between the control and test formulations containing CTE and RAS flavors along with sodium saccharin. Conclusion: CTE and RAS flavors in combination with 0.09% sodium saccharin can achieve a significant taste-masking effect in the dental LID injection.

Double-coated enrofloxacin microparticles with chitosan and alginate: Preparation, characterization and taste-masking effect study

2017 ◽  
Vol 170 ◽  
pp. 247-253 ◽  
Author(s):  
Mengxi Liu ◽  
Daiping Yin ◽  
Hualin Fu ◽  
Fengying Deng ◽  
Guangneng Peng ◽  
...  
Keyword(s):  
Effect Study ◽  
Masking Effect ◽  
Taste Masking

scholarly journals Ethylcellulose in Organic Solution or Aqueous Dispersion Form in Designing Taste-Masked Microparticles by the Spray Drying Technique with a Model Bitter Drug: Rupatadine Fumarate

Polymers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 522 ◽  
Author(s):  
Katarzyna Wasilewska ◽  
Marta Szekalska ◽  
Patrycja Ciosek-Skibinska ◽  
Joanna Lenik ◽  
Anna Basa ◽  
...  
Keyword(s):  
Spray Drying ◽  
Electronic Tongue ◽  
Aqueous Dispersion ◽  
Taste Masking ◽  
Organic Solution ◽  
Aqueous Dispersions ◽  
Innovative Methods ◽  
Pharmaceutical Properties

The taste of drugs is an important factor affecting pharmacotherapy effectiveness, and obtaining formulations with acceptable organoleptic properties is still an ongoing issue in pharmaceutical technology. One of the innovative methods of taste masking is preparation of microparticles by the spray drying technique, utilizing polymers with different physicochemical properties. Rupatadine fumarate (RUP) is one of the newest antihistamines, with an innovative and multidirectional mechanism of action, and an extremely bitter taste. The aim of this work was to investigate the feasibility of utilizing organic or aqueous forms of ethylcellulose (EC) for the preparation of microparticles with RUP by the spray drying technique. Spray dried samples at different drug:polymer ratios were prepared using organic solution (Ethocel®) or aqueous dispersions of EC (Surelease®, Aquacoat® ECD). Evaluation of the taste masking efficacy was performed in vivo in human taste panel, in vitro based on dissolution test, and by self-constructed electronic tongue. It was shown that microparticles obtained from aqueous dispersions of EC have superior pharmaceutical properties in terms of both morphology and taste masking efficacy in comparison to those obtained from organic solution.

scholarly journals Multi-Methodological Quantitative Taste Assessment of Anti-Tuberculosis Drugs to Support the Development of Palatable Paediatric Dosage Forms

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 369 ◽  
Author(s):  
Alison V. Keating ◽  
Jessica Soto ◽  
Claire Forbes ◽  
Min Zhao ◽  
Duncan Q. M. Craig ◽  
...  
Keyword(s):  
Rank Order ◽  
Electronic Tongue ◽  
Taste Masking ◽  
Assessment Data ◽  
Taste Response ◽  
Life Saving ◽  
Taste Assessment ◽  
Therapeutic Doses

The unpalatability of antituberculosis drugs is often cited as a major cause of non-adherence in children, yet limited quantitative taste assessment data are available. The aim of this research was to quantify the bitterness of isoniazid, rifampicin, pyrazinamide, and ethambutol dihydrochloride using two in vivo (a human taste panel and a rat brief-access taste aversion (BATA) model) and one in vitro (sensor) method. The response of the Insent TS-5000Z electronic tongue was compared to the in vivo drug concentration found to elicit and suppress half the maximum taste response (EC50 in human and IC50 in rats). Using dose-relevant concentrations, an overarching rank order of bitterness was derived (rifampicin > ethambutol > pyrazinamid~isoniazid). In vitro, only ethambutol exhibited a linear response for all sensors/concentrations. Based on the EC50/IC50 generated, a ‘taste index’ was proposed to allow for anticipation of the likelihood of taste issues in practice, taking in account the saturability in the saliva and therapeutic doses; ethambutol and isoniazid were found to be the worst tasting using this measure. The study presents the first quantitative taste analysis of these life-saving drugs and has allowed for a comparison of three methods of obtaining such data. Such information allows the operator to identify and prioritise the drugs requiring taste masking to produce palatable formulations.

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