Methanolic extract of Hibiscus asper leaves improves spatial memory deficits in the 6-hydroxydopamine-lesion rodent model of Parkinson's disease

2011 ◽  
Vol 133 (2) ◽  
pp. 773-779 ◽  
Author(s):  
Harquin Simplice Foyet ◽  
Lucian Hritcu ◽  
Alin Ciobica ◽  
Marius Stefan ◽  
Pierre Kamtchouing ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Spatial Memory ◽  
Methanolic Extract ◽  
Memory Deficits ◽  
Rodent Model ◽  
6 Hydroxydopamine

Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease

2011 ◽  
Vol 71 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Lucian Hritcu ◽  
Alin Ciobica ◽  
Marius Stefan ◽  
Marius Mihasan ◽  
Lavinia Palamiuc ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Spatial Memory ◽  
Memory Deficits ◽  
Rodent Model ◽  
Stress Damage ◽  
And Oxidative Stress

scholarly journals Diverse Short-Term Dynamics of Inhibitory Synapses Converging on Striatal Projection Neurons: Differential Changes in a Rodent Model of Parkinson’s Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Janet Barroso-Flores ◽  
Marco A. Herrera-Valdez ◽  
Violeta Gisselle Lopez-Huerta ◽  
Elvira Galarraga ◽  
José Bargas
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Voltage ◽  
Rodent Model ◽  
Inhibitory Synapses ◽  
Projection Neurons ◽  
Striatal Neurons ◽  
Dopamine Depletion ◽  
Short Term ◽  
6 Hydroxydopamine

Most neurons in the striatum are projection neurons (SPNs) which make synapses with each other within distances of approximately 100 µm. About 5% of striatal neurons are GABAergic interneurons whose axons expand hundreds of microns. Short-term synaptic plasticity (STSP) between fast-spiking (FS) interneurons and SPNs and between SPNs has been described with electrophysiological and optogenetic techniques. It is difficult to obtain pair recordings from some classes of interneurons and due to limitations of actual techniques, no other types of STSP have been described on SPNs. Diverse STSPs may reflect differences in presynaptic release machineries. Therefore, we focused the present work on answering two questions: Are there different identifiable classes of STSP between GABAergic synapses on SPNs? And, if so, are synapses exhibiting different classes of STSP differentially affected by dopamine depletion? Whole-cell voltage-clamp recordings on SPNs revealed three classes of STSPs: depressing, facilitating, and biphasic (facilitating-depressing), in response to stimulation trains at 20 Hz, in a constant ionic environment. We then used the 6-hydroxydopamine (6-OHDA) rodent model of Parkinson’s disease to show that synapses with different STSPs are differentially affected by dopamine depletion. We propose a general model of STSP that fits all the dynamics found in our recordings.

Neuroprotective effect of the methanolic extract of Hibiscus asper leaves in 6-hydroxydopamine-lesioned rat model of Parkinson's disease

2011 ◽  
Vol 137 (1) ◽  
pp. 585-591 ◽  
Author(s):  
Lucian Hritcu ◽  
Harquin Simplice Foyet ◽  
Marius Stefan ◽  
Marius Mihasan ◽  
Acha Emmanuel Asongalem ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Methanolic Extract ◽  
Neuroprotective Effect ◽  
6 Hydroxydopamine

scholarly journals Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Napatr Sriraksa ◽  
Jintanaporn Wattanathorn ◽  
Supaporn Muchimapura ◽  
Somsak Tiamkao ◽  
Kamoltip Brown ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Spatial Memory ◽  
Rat Model ◽  
Wistar Rats ◽  
Once Daily ◽  
Enhancing Effect ◽  
Neuron Density ◽  
Male Wistar Rats ◽  
6 Hydroxydopamine

Oxidative stress has been reported to induce cognitive impairment in Parkinson's disease. This paper aimed to determine the effect of quercetin, a substance possessing antioxidant activity, on the cognitive function in a rat model of Parkinson's disease. Male Wistar rats, weighing 200–250 g, were orally given quercetin at doses of 100, 200, 300 mg/kg BW once daily for a period of 14 days before and 14 days after the unilateral lesion of right substantia nigra induced by 6-hydroxydopamine (6-OHDA). Their spatial memory was assessed at 7 and 14 days of treatment and neuron density was determined, malondialdehyde (MDA) level, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated at the end of the experiment. In addition, the activity of acetylcholinesterase (AChE) was also measured. It was found that all doses of quercetin enhanced spatial memory. Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.

scholarly journals Metabotropic Glutamate Receptors 5 Blockade Reverses Spatial Memory Deficits in a Mouse Model of Parkinson's Disease

2008 ◽  
Vol 34 (3) ◽  
pp. 729-738 ◽  
Author(s):  
Elvira De Leonibus ◽  
Francesca Managò ◽  
Francesco Giordani ◽  
Francesco Petrosino ◽  
Sebastien Lopez ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Spatial Memory ◽  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Memory Deficits ◽  
Metabotropic Glutamate

scholarly journals Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s disease

2016 ◽  
Vol 74 (9) ◽  
pp. 723-729 ◽  
Author(s):  
Z Rajaei ◽  
M Hosseini ◽  
H Alaei
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Oxidative Damage ◽  
Medial Forebrain Bundle ◽  
Memory Performance ◽  
Thiobarbituric Acid ◽  
Memory Deficits ◽  
Thiobarbituric Acid Reactive Substances ◽  
Male Wistar Rats ◽  
6 Hydroxydopamine

ABSTRACT The purpose of the present study was to investigate the effect of crocin on brain oxidative damage and memory deficits in a 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease. Male Wistar rats were subjected to unilateral injection of 6-OHDA (16 µg) into the medial forebrain bundle and treated with crocin (30 and 60 mg/kg) for six weeks. The rats were tested for memory performance at six weeks after 6-OHDA infusion, and then were killed for the estimation of biochemical parameters. The increase in thiobarbituric acid reactive substances (TBARS) and nitrite levels in the hippocampus were observed in the 6-OHDA lesioned rats, which was accompanied by memory deficits in a passive avoidance test at the end of week 6. Moreover, treatment with crocin decreased TBARS and nitrite levels in the hippocampus, and improved aversive memory. The present study conclusively demonstrated that crocin acts as an antioxidant and anti-inflammatory agent in the hippocampus of parkinsonian rats and could improve aversive memory through its properties.

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