Evaluation of diuretic activity of Amaranthus spinosus Linn. aqueous extract in Wistar rats

2012 ◽  
Vol 140 (2) ◽  
pp. 424-427 ◽  
Author(s):  
Arul Amuthan ◽  
Bharti Chogtu ◽  
K.L. Bairy ◽  
Sudhakar ◽  
Mungli Prakash
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Diuretic Activity ◽  
Amaranthus Spinosus

scholarly journals Evaluation of Diuretic Activity of Aqueous Extract of Ripe Fruit Pulp of Tamarindus indica L. in Rats

2016 ◽  
Vol 14 (2) ◽  
pp. 22-27
Author(s):  
Sammodavardhana Kaundinnyayana ◽  
Satish Kumar Mahadevaiahcandraiah ◽  
Alaya Laxminarayana Udupa
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Urine Volume ◽  
Fruit Pulp ◽  
Tamarindus Indica ◽  
Diuretic Activity ◽  
Ripe Fruit ◽  
Natriuretic Effect ◽  
Magnesium Excretion ◽  
Clinical Conditions

Introduction: Diuresis is an important pharmacological property which is useful in many clinical conditions. There is a need of better diuretics with lesser adverse effects in comparison to currently available diuretics. The study aimed to evaluate the diuretic activity of aqueous extract of fruit pulp of Tamarindus indica L. in rats.Methods: The study was undertaken with aqueous extract of fruit pulp of Tamarindus indica in three doses: 300 mg/kg, 600 mg/kg and1200 mg/kg for its diuretic activity in comparison with standard (furosemide) and vehicle control (normal saline) in Wistar rats. Urine volume and electrolytes were measured after 24 hours of drug administration.Results: Aqueous extract of fruit pulp of Tamarindus indica at the dose of 1200 mg/kg exhibited significant diuretic activity (p<0.05) without significant natriuretic effect. Magnesium excretion was also significantly increased in comparison to control group.Conclusion: Aqueous extract of fruit pulp of Tamarindus indica has significant diuretic activity in Wistar rats.  

scholarly journals Study of diuretic activity of aqueous extract of amaranthus spinosus linn on rats

2016 ◽  
Vol 6 (1) ◽  
pp. 141 ◽  
Author(s):  
Shravani Potllapalli ◽  
Jagannath Narumalla ◽  
Naga Teja Pavani A. ◽  
Damodaram Govindadas ◽  
Somashekar S. Chikkannasetty
Keyword(s):  
Aqueous Extract ◽  
Normal Saline ◽  
Urine Analysis ◽  
Total Concentration ◽  
Urine Volume ◽  
Control Group ◽  
Standard Group ◽  
Diuretic Activity ◽  
Amaranthus Spinosus ◽  
Group I

Background: Traditional Siddha medicine literature claims that the Amaranthus spinosus Linn. Whole plant possesses diuretic property. The aim of the present study is to investigate the diuretic activity of aqueous extract of amaranthus spinosus linn on rats.Methods: The rats were randomly divided into four groups of six animals each and deprived of food for 18 hours before the experiments. Control (Group I) rats were treated with Normal saline (5ml/Kg,) and Standard (Group II) rats were administered furosemide 15mg/Kg, I.P. Group III and IV were treated with Aqueous extract of Amaranthus spinosus Linn (AEAS) 250 and 500 mg/kg in normal saline respectively, The urine was collected after 5 and 24 hours. The urine volume and the total concentration of Na+, K+, and Cl- in the urine were estimated. The data were presented as mean ± standard deviation and analyzed using one-way analysis of variance and Student's "t"-test. P <0.05 was considered statistically significant. Conventional windows software was used for statistical analysis.Results: Urine analysis showed that Na+, K+, and Cl- levels were significantly (p<0.05) increased with AEAS 250 and 500 mg/kg as rats treated with furosemide 15mg/kg. Urine volume is significantly (p<0.05) increased in rats treated with drugs (AEAS 500 mg/kg and furosemide 15mg/kg) compared to normal saline 25ml/Kg, treated rats at 5 and 24 hours.Conclusions: These data suggest that AEAS has produced notable diuretic effect which appeared to be comparable to that produced by the standard diuretic furosemide.

Diuretic activity and toxicity study of the aqueous extract of Cola nitida seed on markers of renal function and electrolytes in rats

2016 ◽  
Vol 13 (4) ◽  
Author(s):  
Mirian Nnemdi Ashibuogwu ◽  
Olukayode Isaac Adeosun ◽  
Rufus Ojo Akomolafe ◽  
Douglas Olaniyi Sanni ◽  
Olaoluwa Sesan Olukiran
Keyword(s):  
Renal Function ◽  
Aqueous Extract ◽  
Urine Output ◽  
Wistar Rats ◽  
Control Group ◽  
Diuretic Activity ◽  
Morning Sickness ◽  
Male Wistar Rats ◽  
Urine Concentrations ◽  
Cola Nitida

AbstractBackgroundis a plant, conventionally used in Africa in the treatment of various ailments such as migraine, morning sickness and indigestion. The aim of the present study was to explore the diuretic activity of the aqueous extract ofMethodsThe study was divided into diuretic and subchronic studies. Twenty-five male Wistar rats weighing between 140 and 180 ResultsThe results of the diuretic study showed that the AECONS at all doses used and furosemide produced a significant increase in urine output with respect to the control group. AECONS also induced a significant increase in the urine concentrations of NaConclusionsIt is concluded that AECONS induced diuresis which is associated with increased Na

Biochemical and Haemopoietic Effects of Aqueous Extract of Gnetum Africanum (Ukazi) on Male and Female Albino Wistar Rats

2018 ◽  
Vol 8 (4) ◽  
pp. 061-065
Author(s):  
F.N OGUWIKE ◽  
◽  
I.C IFEDI ◽  
C.N DIM ◽  
C.P IGWEDIBIA ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Male And Female

scholarly journals Antioxidant Evaluation of the Aqueous Extract of Hulls of Campsiandra laurifolia in Colitis Induced by Acetic Acid in Wistar Rats

2021 ◽  
Vol 41 (02) ◽  
pp. 138-144
Author(s):  
Lucas Petitemberte de Souza ◽  
Henrique Sarubbi Fillmann ◽  
Sandielly Rebeca Benitez da Fonseca ◽  
Marilda da Silva Brasil ◽  
Norma Anair Possa Marroni ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Phenolic Compounds ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Antioxidant Activities ◽  
Experimental Colitis ◽  
Anal Pressure ◽  
Antioxidant Power ◽  
Significance Level ◽  
Sphincter Anal

AbstractDue to the ethnopharmacological use of Campsiandra laurifolia (Fabaceae), popularly known as Acapurana, to treat wounds and ulcers, associated with the lack of alternative treatments for intestinal inflammations such as ulcerative colitis (UC), the present work sought to characterize its phytochemical and antioxidant activities, and to evaluate remedial action in experimental colitis with acetic acid. Phytochemical analyzes were performed through qualitative and quantitative colorimetric tests of the main secondary metabolites. In the colitis model, 24 male Wistar rats aged ± 60 days old were used, divided into 4 groups: Control (CO) control + aqueous extract of C. laurifolia 50 mg/kg (CO + A50); Colitis (CL); and Colitis + aqueous extract of C. laurifolia 50 mg/kg (CL + A50). Measurement of sphincter anal pressure and histological tests of the large intestine, lipoperoxidation (LPO), enzyme activity of superoxide dismutase (SOD), and levels of glutathione (GSH) were performed. For statistical analysis, the oxidative stress (OS) results were expressed as means ± standard error, adopting a significance level of p < 0.05. The screening indicated the presence of flavonoids, saponins and tannins in the extract, with high levels of phenolic compounds and tannins, and was related to high antioxidant capacity. In the histological analysis, the CL group presented loss of the crypts, edema and inflammatory infiltrate. The use of C. laurifolia extract restructured the crypts, decreased edema and increased sphincter anal pressure, with a decrease in LPO, SOD, and an increase in GSH. It is suggested that the use of C. laurifolia extract reduces OS due to its antioxidant power conferred by the phenolic compounds present in the extract.

POTENTIAL DIURETIC EFFECT OF CURCUMA AMADA ROXB. RHIZOME EXTRACTS

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (04) ◽  
pp. 34-38
Author(s):  
P Bommannavar ◽  
◽  
K. Patil
Keyword(s):  
Aqueous Extract ◽  
Urine Volume ◽  
Control Group ◽  
Aqueous Extracts ◽  
Diuretic Activity ◽  
Curcuma Amada ◽  
Male Wistar Rats ◽  
Total Urine ◽  
Dose Dependent Increase ◽  
Dose Dependent

The present study was undertaken to establish the diuretic activity of alcoholic and aqueous extract of dried rhizomes of Curcuma amada Roxb in rats. Alcoholic and aqueous extracts of rhizomes were administered to experimental male Wistar rats orally at doses of 250 and 500 mg/kg and compared with furosemide (10 mg/kg) as the reference standard. The parameters measured for diuretic activity were total urine volume, urine electrolyte concentration such as sodium, potassium and chloride have been evaluated. The rats treated with alcoholic and aqueous extract of Curcuma amada in a dose of 250 and 500 mg/kg showed higher urine output when compared to the respective control. Both alcoholic and aqueous extracts have showed a significant dose-dependent increase in the excretion of electrolytes when compared to the control group. The result indicates that alcoholic and aqueous extract is an effective natriuretic and kaliuretic diuretic, which supports the traditional claim about the Curcuma amada Roxb being used as diuretics.

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