scholarly journals Anti-cancer potential of polysaccharide extracted from hawthorn (Crataegus.) on human colon cancer cell line HCT116 via cell cycle arrest and apoptosis

2020 ◽  
Vol 64 ◽  
pp. 103677 ◽  
Author(s):  
Lei Ma ◽  
Guanying Bianca Xu ◽  
Xinyu Tang ◽  
Cheng Zhang ◽  
Wen Zhao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cancer Cell Line ◽  
Human Colon ◽  
Colon Cancer Cell Line ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Cycle Arrest ◽  
Anti Cancer

Cell Cycle-Dependent Regulation of N-Acetylglucosaminyltransferase-III in a Human Colon Cancer Cell Line, Colo201

2000 ◽  
Vol 374 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Rujun Kang ◽  
Yoshitaka Ikeda ◽  
Eiji Miyoshi ◽  
Wenge Wang ◽  
Wei Li ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Line ◽  
Cancer Cell Line ◽  
Human Colon ◽  
Colon Cancer Cell Line ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Cycle Dependent

scholarly journals Effect of 5-Fluorouracil on Cell Cycle Regulatory Proteins in Human Colon Cancer Cell Line

1999 ◽  
Vol 90 (6) ◽  
pp. 677-684 ◽  
Author(s):  
Haruo Takeda ◽  
Minoru Haisa ◽  
Yoshio Naomoto ◽  
Ryuichi Kawashima ◽  
Kazutaka Satomoto ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cancer Cell Line ◽  
Human Colon ◽  
Colon Cancer Cell Line ◽  
Colon Cancer Cell ◽  
Regulatory Proteins ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Cell Cycle Regulatory Proteins

scholarly journals Antitumor activity, cell cycle arrest and apoptosis induction in human colon cancer cell line by Primula macrophylla extracts

2017 ◽  
Vol 12 (2) ◽  
pp. 4
Author(s):  
Di-Wen Shou ◽  
Yue-Lin Zheng
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Methanol Extract ◽  
Cancer Cell Line ◽  
Human Colon ◽  
Colon Cancer Cell Line ◽  
Human Colon Cancer Cell ◽  
Apoptosis Induction ◽  
Human Colon Cancer ◽  
Cycle Arrest

<p class="Abstract">The primary objective of the current work was to investigate the antitumor potential of <em>Primula macrophylla</em> extracts in human colon cancer cell line (Colo-205) along with evaluating the effects on apoptosis induction, cell cycle arrest and mitochondrial membrane potential. Cell viability was assessed by tetrazolium-based MTT assay. Flow cytometry measurement was carried out to assess the effect of the extract on cell cycle phase distribution and mitochondrial transmembrane potential. Results showed that <em>P.  macrophylla</em> methanol extract was effective and exhibited highest cell growth inhibition (IC<sub>50</sub> value, 26.17 μg/mL). Methanol extract significantly increased the side-scattering profile of Colo-205 cells in concentration-dependent pattern. Exposure of Colo-205 cells with different concentrations of the methanol extract (0-80 μg/mL) caused dose-dependent G0/G1 cell cycle arrest along with inducing apoptotic cascade by increasing the population of cells at G0/G1 phase. Furthermore, methanol extract treatment caused an increase in mitochondrial membrane depolarization in Colo-205 cells.</p><p class="Abstract"><strong>Video Clip of Methodlogy</strong> (3 min 17 sec): <a href="https://youtube.com/v/yy-rCjDN830">Click</a>  <a href="https://youtube.com/watch?v=yy-rCjDN830">If failed</a></p>

Sign in / Sign up

Export Citation Format

Share Document