scholarly journals Lifestyle related changes with partially hydrolyzed guar gum dietary fiber in healthy athlete individuals – A randomized, double-blind, crossover, placebo-controlled gut microbiome clinical study

2020 ◽  
Vol 72 ◽  
pp. 104067
Author(s):  
Mahendra P. Kapoor ◽  
Masaaki Koido ◽  
Mikiko Kawaguchi ◽  
Derek Timm ◽  
Makoto Ozeki ◽  
...  
Keyword(s):  
Clinical Study ◽  
Dietary Fiber ◽  
Gut Microbiome ◽  
Guar Gum ◽  
Double Blind ◽  
Healthy Athlete ◽  
Partially Hydrolyzed Guar Gum

scholarly journals A Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Trial of Partially Hydrolyzed Guar Gum Dietary Fiber for the Improved Gut Microbiome in Healthy Athletes

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1568-1568
Author(s):  
Mahendra Kapoor ◽  
Masaaki Koido ◽  
Mikiko Kawaguchi ◽  
Derek Timm ◽  
Makoto Ozeki
Keyword(s):  
Quality Of Life ◽  
Dietary Fiber ◽  
Relative Abundance ◽  
Gut Microbiome ◽  
Guar Gum ◽  
Controlled Study ◽  
Pcr Analysis ◽  
Rrna Gene ◽  
Partially Hydrolyzed Guar Gum

Abstract Objectives The widespread impact of the gut microbiota in human health has emerged in recent years. Changes in diet and exercise can alter the gut microbiomes of active athletes. We performed a randomized, controlled study to evaluate the relationship between the partially hydrolyzed guar gum (PHGG) prebiotic dietary fiber and the relative abundance of the gut microbiomes in the context of changes in lifestyle-related factors, and their significant correlation with fecal defecation characteristics in healthy athletes. Methods Subjects followed a daily 6 grams dietary intake of either PHGG or placebo for four weeks, following a three weeks washout period, subjects followed another four weeks of crossover alternative administration. Fecal defecation characteristics were assessed using a questionnaire along with the quality of life (QOL) questions and gut microbiome abundance was determined by 16S rRNA gene sequencing and real-time PCR analysis. Results The alteration in gastrointestinal microbiomes relative abundance was correlated to representative changes in fecal defecation characteristics, especially in ameliorating diarrhea (P = 0.035) and fecal excretory feeling (P = 0.038). The PHGG intake led to a significant increase in phylum Actinobacterium (P = 0.04), along with a significant decrease in Bacteroidetes (P = 0.036). A trending decrease in Firmicutes (P = 0.09) Awas noticed. Also, a significant alteration in the relative abundance of Bifidobacterium (P = 0.047) and Clostridium subcluster XI (P = 0.044) were observed with PHGG intake compared with placebo. Principal component analysis and hierarchical clustering analysis represented a clear overview of the distribution of quality of life covariates evaluated in the study. Conclusions Improved diarrhea was associated with the relative abundance of phylum Firmicutes/Bacteroidetes ratio and genera Bacteroides/Prevotella ratio for the PHGG intervention compared to placebo. The finding reveals that even at relatively low dosage, intake of prebiotic PHGG fiber modulates gut microbiomes, and thus improves gastrointestinal health. Overall, the quality of lifestyle factors was significantly improved with PHGG consumption. Funding Sources Taiyo Kagaku, University of Tsukuba, and Otsuma Women's University equally contributed to the study.

scholarly journals Effect of guar fiber on physicochemical, textural and sensory properties of sweetened strained yoghurt

2020 ◽  
Vol 10 (3) ◽  
pp. 5564-5568 ◽  
Keyword(s):  
Molecular Weight ◽  
Dietary Fiber ◽  
Dairy Products ◽  
Guar Gum ◽  
Milk Products ◽  
Sensory Acceptability ◽  
Low Viscosity ◽  
Four Levels ◽  
Partially Hydrolyzed Guar Gum ◽  
Hydrolysis Of

Naturally, milk & milk products are devoid of dietary fiber hence there is scope of dietary fiber fortification of dairy products. In the present study, sweetened strained yoghurt was fortified with dietary fiber using partially hydrolyzed guar gum (PHGG). PHGG is prepared by enzymatic hydrolysis of guar gum & exhibit low viscosity & molecular weight as compared to guar gum. PHGG was added to sweetened strained yoghurt at four levels i.e. 2.5%, 5.0%, 7.5% & 10% (w/w basis). Control & PHGG fortified sweetened strained yoghurt samples were subjected to textural (firmness, adhesiveness & cohesiveness) and sensory evaluation. Results revealed that PHGG can be utilized for fiber fortification of sweetened strained yoghurt. PHGG fortification in sweetened strained yoghurt decreased the firmness & adhesiveness whereas increased the cohesiveness. Sweetened strained yoghurt fortified with PHGG at 5% level showed overall sensory acceptability equivalent to control sweetened strained yoghurt.

scholarly journals The Effect of Voluntary Exercise on Gut Microbiota in Partially Hydrolyzed Guar Gum Intake Mice under High-Fat Diet Feeding

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2508
Author(s):  
Takafumi Aoki ◽  
Eri Oyanagi ◽  
Chihiro Watanabe ◽  
Nanako Kobiki ◽  
Suzuka Miura ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Gut Microbiota ◽  
Dietary Fiber ◽  
High Fat Diet ◽  
Guar Gum ◽  
Wheel Running ◽  
Control Diet ◽  
Voluntary Exercise ◽  
High Fat ◽  
Partially Hydrolyzed Guar Gum

Although dietary fiber treatment alters the gut microbiota and its metabolite production, it is unclear whether or not exercise habits can have a supplemental effect on changes in gut microbiota in dietary fiber-treated mice. To clarify the supplemental effect of voluntary exercise on gut microbiota in partially hydrolyzed guar gum (PHGG), which is a soluble dietary fiber, treated mice under high-fat diet (HFD) feeding, 4-week-old male C57BL/6J mice (n = 80) were randomly divided into two dietary groups: the control-diet (CD) and HFD. Then, each dietary group was treated with or without PHGG, and with or without wheel running. After the experimental period, measurement of maximal oxygen consumption, a glucose tolerance test and fecal materials collection for analysis of gut microbiota were carried out. Voluntary exercise load in PHGG treatment under HFD feeding showed the supplemental effect of exercise on obesity (p < 0.01) and glucose tolerance (p < 0.01). Additionally, in both CD and HFD groups, voluntary exercise accelerated the decrease in the Firmicutes/Bacteroidetes ratio in mice fed with PHGG (p < 0.01). These findings suggest that voluntary exercise might activate the prevention of obesity and insulin resistance more via change in gut microbiota in mice administrated with PHGG.

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