Analysis of retinal microvasculature in Fuchs’ uveitis syndrome. Retinal microvasculature in Fuchs’ uveitis

AbstractBiomarker tests of Alzheimer’s disease (AD) are invasive and expensive. Recent developments in optical coherence tomography (OCT) and OCT angiography (OCTA) have enabled noninvasive, cost-effective characterization of retinal layer vasculature and thickness. Using OCTA and OCT, we characterized retinal microvascular changes in the mild cognitive impairment (MCI) stage of AD and assessed their correlation with structural changes in each retinal neuronal layer. We also evaluated the effect of the APOE-ε4 genotype on retinal microvasculature and layer thickness. Retinal layer thickness did not differ between MCI patients (40 eyes) and controls (37 eyes, all p > 0.05). MCI patients had lower vessel density (VD) (p = 0.003) of the superficial capillary plexus (SCP) and larger foveal avascular zone area (p = 0.01) of the deep capillary plexus (DCP) than those of controls. VD of the SCP correlated with the ganglion cell layer (r = 0.358, p = 0.03) and inner plexiform layer thickness (r = 0.437, p = 0.007) in MCI patients. APOE-ε4-carrying MCI patients had a lower VD of the DCP than non-carriers (p = 0.03). In conclusion, retinal microvasculature was reduced in patients with AD-associated MCI, but retinal thickness was not changed; these changes might be affected by the APOE genotype. OCTA of the retinal microvasculature may be useful to detect vascular changes in AD.

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Development of revised diagnostic criteria for Fuchs’ uveitis syndrome in a Chinese population

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2021-319343 ◽

2021 ◽

pp. bjophthalmol-2021-319343

Author(s):

Peizeng Yang ◽

Wanyun Zhang ◽

Zhijun Chen ◽

Han Zhang ◽

Guannan Su ◽

...

Keyword(s):

Diagnostic Criteria ◽

Clinical Symptoms ◽

Southern China ◽

High Sensitivity ◽

Northern China ◽

Chinese Patients ◽

Tertiary Referral Centre ◽

Tree Algorithms ◽

Vitreous Opacities ◽

Fuchs Uveitis Syndrome

Background/aimsFuchs’ uveitis syndrome (FUS) is one of the frequently misdiagnosed uveitis entities, which is partly due to the absence of internationally recognised diagnostic criteria. This study was performed to develop and evaluate a set of revised diagnostic criteria for FUS.MethodsThe clinical data of Chinese patients with FUS and patients with non-FUS were collected and analysed from a tertiary referral centre between April 2008 and December 2020. A total of 593 patients with FUS and 625 patients with non-FUS from northern China were enrolled for the development of diagnostic criteria for FUS. Three hundred and seventy-seven patients with FUS and 503 patients with non-FUS from southern China were used to validate the criteria. Clinical symptoms and ocular signs were collected from all patients with FUS and patients with non-FUS. Multivariate two-step cluster analysis, logistic regression and decision tree algorithms in combination with the clinical judgement of uveitis experts were used to revise diagnostic criteria for FUS.ResultsThree essential findings including diffuse iris depigmentation, absence of posterior synechiae, mild inflammation in the anterior chamber at presentation and five associated findings including mostly unilateral involvement, cataract, vitreous opacities, absence of acute symptoms and characteristic iris nodules were used in the development of FUS diagnostic criteria. All essential findings were required for the diagnosis of FUS, and the diagnosis was further strengthened by the presence of associated findings.ConclusionRevised diagnostic criteria for FUS were developed and validated by analysing data from Chinese patients and showed a high sensitivity (96.55%) and specificity (97.42%).

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Retraction notice to Retinal microvasculature alterations in neuromyelitis optica spectrum disorders before optic neuritis [Multiple sclerosis and related disorders 44 (2020) 102277]

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2020.102617 ◽

2020 ◽

Vol 44 ◽

pp. 102617

Author(s):

William Robert Kwapong ◽

Jueyue Yan ◽

Lingfen Xie ◽

Hanpei Miao ◽

Yu Wang ◽

...

Keyword(s):

Multiple Sclerosis ◽

Optic Neuritis ◽

Neuromyelitis Optica ◽

Neuromyelitis Optica Spectrum Disorders ◽

Retinal Microvasculature ◽

Spectrum Disorders ◽

Retraction Notice

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Relationship between birth weight and retinal microvasculature in newborn infants

Journal of Perinatology ◽

10.1038/jp.2011.118 ◽

2011 ◽

Vol 32 (6) ◽

pp. 443-447 ◽

Cited By ~ 8

Author(s):

Y Kandasamy ◽

R Smith ◽

I M R Wright ◽

L Hartley

Keyword(s):

Birth Weight ◽

Newborn Infants ◽

Retinal Microvasculature

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Update on Fuchs?? uveitis syndrome

Current Opinion in Ophthalmology ◽

10.1097/01.icu.0000187056.29563.8d ◽

2005 ◽

Vol 16 (6) ◽

pp. 356-363 ◽

Cited By ~ 71

Author(s):

Quresh Mohamed ◽

Ehud Zamir

Keyword(s):

Fuchs Uveitis Syndrome

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Can the retinal microvasculature offer clues to cardiovascular risk factors in early life?

Acta Paediatrica ◽

10.1111/apa.12294 ◽

2013 ◽

Vol 102 (10) ◽

pp. 941-946 ◽

Cited By ~ 12

Author(s):

Ling-Jun Li ◽

Yung-Seng Lee ◽

Tien-Yin Wong ◽

Carol Yim-Lui Cheung

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Early Life ◽

Retinal Microvasculature

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Retinal microvascular parameters are not associated with diabetes in the Northern Ireland Cohort for the Longitudinal Study of Ageing

Irish Journal of Medical Science (1971 -) ◽

10.1007/s11845-021-02704-1 ◽

2021 ◽

Author(s):

Rachael Ann O’Neill ◽

Alexander Peter Maxwell ◽

Frank Kee ◽

Ian Young ◽

Bernadette McGuinness ◽

...

Keyword(s):

Longitudinal Study ◽

Northern Ireland ◽

Glycated Haemoglobin ◽

Haemoglobin A1c ◽

Cross Sectional ◽

Non Invasive ◽

Retinal Microvasculature ◽

Diabetes Status ◽

Automated Software ◽

Sectional Analysis

Abstract Background The retinal microvasculature offers unique non-invasive evaluation of systemic microvascular abnormalities. Previous studies reported associations between retinal microvascular parameters (RMPs) and diabetes. The aim of this study was to assess associations between RMPs and diabetes in a cross-sectional analysis of older persons from the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA). Methods RMPs (central retinal arteriolar/venular equivalents, arteriolar to venular ratio, fractal dimension, and tortuosity) were measured from optic disc-centred fundus images using semi-automated software. Associations were assessed between RMPs and diabetes status with adjustment for potential confounders. Results Data were included for 1762 participants with 209 classified as having diabetes. Participants had a mean age of 62.1 ± 8.5 years, and 54% were female. As expected, participants with diabetes had significantly higher mean glycated haemoglobin A1c compared to participants without diabetes (57.4 ± 17.6 mmol/mol versus 37.0 ± 4.2 mmol/mol, respectively). In unadjusted and minimally adjusted regression, arteriolar to venular ratio, arteriolar tortuosity and venular tortuosity were significantly associated with diabetes (minimally adjusted odds ratio [OR] = 0.85; 95% confidence intervals [CIs] 0.73, 0.99; P = 0.04, OR = 1.18; 95% CI 1.02, 1.37; P = 0.03 and OR = 1.20; 95% CI 1.04, 1.38; P = 0.01, respectively), although all failed to remain significant following adjustment for potential confounders. No additional associations between other RMPs and diabetes were detected. Conclusion Despite previously reported associations between diabetes and RMPs, our study failed to corroborate these associations in an older community-based cohort.

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Clinical and laboratory changes in the hemostasis system in patients with optic nerve vasculitis

Russian ophthalmology of children ◽

10.25276/2307-6658-2021-1-23-27 ◽

2021 ◽

pp. 23-27

Author(s):

T.V. Shelkovnikova ◽

◽

H.P. Takhchidi ◽

G.V. Nikolaeva ◽

G.V. Vavin ◽

...

Keyword(s):

Optic Nerve ◽

Research Methods ◽

Lupus Anticoagulant ◽

Young Patients ◽

Venous Stasis ◽

Hemostasis System ◽

Hemostatic System ◽

Retinal Microvasculature ◽

Confirmatory Tests ◽

Laboratory Changes

Purpose. Clinical and laboratory studies of the hemostasis system in patients with optic nerve vasculitis. Materials and methods. Medical records and case history of 45 people (49 eyes) were analyzed, of which pathology in two eyes was detected in 4 people (8 eyes). The study involved 24 men and 21 women aged 17 to 35 years. The follow-up period ranged from 3 months to 5 years. Standard ophthalmic research methods and special research methods were used. Laboratory methods for the study of hemostasis included the detection of lupus anticoagulant was carried out using poison tests, as well as confirmatory tests with donor plasma and corrective phospholipids. Results. Retinopathy of the type of venous stasis was found in 30 people, neuropathy of the type of stagnant disc – in 15 people. In young patients after a viral infection with damage to the optic nerve in clinical form, retinopathy such as venous stasis and congestive optic nerve head with lupus anticoagulant was found in 73.4% of cases. In patients with vasculitis of the optic nerve with lupus anticoagulant, disturbances in the vascular-platelet and plasma-coagulation links in the hemostatic system were revealed. Conclusion. Lupus anticoagulant significantly reduces thromboresistance of the endothelium of the retinal microvasculature and enhances hypercoagulation, breaks the natural regulation of the hemostasis system and aggravates ischemia of the retina, optic nerve, participates in the pathogenesis of clinical forms of optic nerve vasculitis. Key words: hemostatic system, lupus anticoagulant, thrombophilia, optic nerve vasculitis.

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