Naturally modified nonionic alginate functionalized upconversion nanoparticles for the highly efficient targeted pH-responsive drug delivery and enhancement of NIR-imaging

2018 ◽  
Vol 57 ◽  
pp. 424-435 ◽  
Author(s):  
Salah M. Tawfik ◽  
Mirkomil Sharipov ◽  
Bui The Huy ◽  
Zayakhuu Gerelkhuu ◽  
Dana Biechele-Speziale ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Upconversion Nanoparticles ◽  
Ph Responsive ◽  
Highly Efficient ◽  
Nir Imaging

pH-Responsive unimolecular micelles based on amphiphilic star-like copolymers with high drug loading for effective drug delivery and cellular imaging

2017 ◽  
Vol 5 (33) ◽  
pp. 6847-6859 ◽  
Author(s):  
Xiaoxiao Shi ◽  
Xiaoqian Ma ◽  
Meili Hou ◽  
Yong-E Gao ◽  
Shuang Bai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Cellular Imaging ◽  
Effective Drug ◽  
Ph Responsive ◽  
High Drug ◽  
Nir Imaging ◽  
High Drug Loading

A theranostic nanoplatform based on pH-responsive amphiphilic star-like copolymers for theranostic and NIR imaging applications.

Heterodimers made of metal–organic frameworks and upconversion nanoparticles for bioimaging and pH-responsive dual-drug delivery

2020 ◽  
Vol 8 (6) ◽  
pp. 1316-1325 ◽  
Author(s):  
Danping Ling ◽  
Haihong Li ◽  
Wensong Xi ◽  
Zhuo Wang ◽  
Artur Bednarkiewicz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
Upconversion Nanoparticles ◽  
Ph Responsive ◽  
Metal Organic ◽  
Ingenious Method ◽  
Dual Drug

An ingenious method was developed to grow metal–organic frameworks on the surface of UCNPs, resulting in the UCMOFs@D@5 nanosystem for bioimaging and pH-responsive dual-drug delivery.

A novel strategy for the aqueous synthesis of down-/up-conversion nanocomposites for dual-modal cell imaging and drug delivery

2014 ◽  
Vol 2 (47) ◽  
pp. 8372-8377 ◽  
Author(s):  
Peng Zhao ◽  
Jing Zhang ◽  
Yihua Zhu ◽  
Xiaoling Yang ◽  
Xin Jiang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Cell Imaging ◽  
Ph Responsive ◽  
Aqueous Synthesis ◽  
Luminescence Imaging ◽  
Highly Efficient ◽  
Novel Strategy ◽  
Down Conversion

A highly efficient multifunctional nanoplatform for dual-modal luminescence imaging and pH-responsive drug delivery has been developed on the basis of a facile and novel strategy by covalently binding up-conversion luminescent NaYF4:Yb,Er nanoparticles with down-conversion fluorescent AgInS2–ZnS quantum dots.

Photo- and pH-responsive drug delivery nanocomposite based on o-nitrobenzyl functionalized upconversion nanoparticles

Polymer ◽  
2021 ◽  
pp. 123961
Author(s):  
Xiaotao Wang ◽  
Yebin Yang ◽  
Chuang Liu ◽  
Huiling Guo ◽  
Zhuofan Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Upconversion Nanoparticles ◽  
Ph Responsive

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

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