Construction of a Dual Drug Carrier on the Basis of Hollow Structured Upconversion Nanoparticles for pH‐Responsive Drug Delivery and UCL/MRI Dual Mode Imaging

An ingenious method was developed to grow metal–organic frameworks on the surface of UCNPs, resulting in the UCMOFs@D@5 nanosystem for bioimaging and pH-responsive dual-drug delivery.

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Naturally modified nonionic alginate functionalized upconversion nanoparticles for the highly efficient targeted pH-responsive drug delivery and enhancement of NIR-imaging

Journal of Industrial and Engineering Chemistry ◽

10.1016/j.jiec.2017.08.051 ◽

2018 ◽

Vol 57 ◽

pp. 424-435 ◽

Cited By ~ 13

Author(s):

Salah M. Tawfik ◽

Mirkomil Sharipov ◽

Bui The Huy ◽

Zayakhuu Gerelkhuu ◽

Dana Biechele-Speziale ◽

...

Keyword(s):

Drug Delivery ◽

Upconversion Nanoparticles ◽

Ph Responsive ◽

Highly Efficient ◽

Nir Imaging

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“Dual-Key-and-Lock” dual drug carrier for dual mode imaging guided chemo-photothermal therapy

Biomaterials Science ◽

10.1039/d0bm01400a ◽

2020 ◽

Vol 8 (22) ◽

pp. 6212-6224

Author(s):

Feng Tian ◽

Bin Chi ◽

Chen Xu ◽

Caixue Lin ◽

Zushun Xu ◽

...

Keyword(s):

Drug Resistance ◽

Side Effects ◽

Photothermal Therapy ◽

Drug Carrier ◽

Dual Mode ◽

Dual Drug

Drug resistance and side effects are the two main problems of chemotherapy.

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Multifunctional drug carrier on the basis of 3d–4f Fe/La-MOFs for drug delivery and dual-mode imaging

Journal of Materials Chemistry B ◽

10.1039/c9tb01509d ◽

2019 ◽

Vol 7 (42) ◽

pp. 6612-6622 ◽

Cited By ~ 7

Author(s):

Caixue Lin ◽

Bin Chi ◽

Chen Xu ◽

Cheng Zhang ◽

Feng Tian ◽

...

Keyword(s):

Drug Delivery ◽

Drug Carrier ◽

Drug Carriers ◽

Dual Mode ◽

Simultaneous Imaging

Multifunctional drug carriers for simultaneous imaging and drug delivery have emerged as an important new direction for the treatment of cancer.

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Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽

10.1039/c7md00270j ◽

2017 ◽

Vol 8 (9) ◽

pp. 1797-1805 ◽

Cited By ~ 9

Author(s):

Madhappan Santha Moorthy ◽

Subramanian Bharathiraja ◽

Panchanathan Manivasagan ◽

Kang Dae Lee ◽

Junghwan Oh

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Drug Carrier ◽

Stimuli Responsive ◽

Ph Responsive ◽

Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

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Multifunctional NaLnF4@MOF-Ln Nanocomposites with Dual-Mode Luminescence for Drug Delivery and Cell Imaging

Nanomaterials ◽

10.3390/nano9091274 ◽

2019 ◽

Vol 9 (9) ◽

pp. 1274 ◽

Cited By ~ 6

Author(s):

Wang ◽

Zhao ◽

Gao ◽

Xu ◽

Wang ◽

...

Keyword(s):

Drug Delivery ◽

Cell Imaging ◽

Drug Carrier ◽

Drug Carriers ◽

Water Soluble ◽

Dual Mode ◽

Metal Organic ◽

Lanthanide Metal ◽

Good Biocompatibility ◽

Anti Stokes

Multifunctional nanomaterials for bioprobe and drug carrier have drawn great attention for their applications in the early monitoring the progression and treatment of cancers. In this work, we have developed new multifunctional water-soluble NaLnF4@MOF-Ln nanocomposites with dual-mode luminescence, which is based on stokes luminescent mesoporous lanthanide metal–organic frameworks (MOFs-Y:Eu3+) and anti-stokes luminescent NaYF4:Tm3+/Yb3+ nanoparticles. The fluorescence mechanism and dynamics are investigated and the applications of these nanocomposites as bioprobes and drug carriers in the cancer imaging and treatment are explored. Our results demonstrate that these nanocomposites with the excellent two-color emission show great potential in drug delivery, cancer cell imaging, and treatment, which are attributed to the unique spatial structure and good biocompatibility characteristics of NaLnF4@MOF-Ln nanocomposites.

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