Clinicopathological Features of Endometriosis in Abdominal Wall – Clinical Analysis of 151 Cases

Desmoid-type fibromatosis (DF) is a locally aggressive neoplasm characterized by mutations in the CTNNB1 gene, which encodes the β-catenin protein. We reviewed 85 cases of DF and performed Sanger sequencing for detecting mutations in CTNNB1 and immunostaining for detecting β-catenin localization. We included 70 DF samples, of which 56 cases demonstrated nuclear β-catenin localization and 43 cases harboured CTNNB1 mutations. CTNNB1-mutant DF samples consistently displayed nuclear β-catenin expression and were derived from larger-sized tumours compared to samples with wild-type CTNNB1. When we further classified DF cases into 2 subgroups based on the type of specimen, excised specimens with nuclear β-catenin expression frequently displayed CTNNB1 mutation and no statistical correlation between nuclear β-catenin expression and CTNNB1 mutation was observed in biopsies. When we classified CTNNB1 mutation cases into 2 subgroups (DF with T41A or T41I, and DF with S45F or S45P), T41A or T41I mutations were observed more frequently in males than in females. Additionally, DF tumours harbouring S45F or S45P mutations were located more frequently in the abdominal wall than tumours with T41A or T41I mutations. In conclusion, CTNNB1 mutation correlates with nuclear β-catenin expression in larger or excised DF tumours, and DF harbouring CTNNB1 mutations manifest variable clinical presentations.

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EP04.22: Prenatal diagnosis and clinical analysis of fetal abdominal wall defect and chromosome abnormalities

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.21177 ◽

2019 ◽

Vol 54 (S1) ◽

pp. 254-255

Author(s):

P. Chen

Keyword(s):

Prenatal Diagnosis ◽

Abdominal Wall ◽

Abdominal Wall Defect ◽

Clinical Analysis ◽

Chromosome Abnormalities ◽

Wall Defect

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Clinical analysis of high-intensity focussed ultrasound ablation for abdominal wall endometriosis: a 4-year experience at a specialty gynecological institution

International Journal of Hyperthermia ◽

10.1080/02656736.2018.1534276 ◽

2018 ◽

Vol 36 (1) ◽

pp. 87-94 ◽

Cited By ~ 4

Author(s):

Zhang Xiao-Ying ◽

Duan Hua ◽

Wang Jin-Juan ◽

Guo Ying-Shu ◽

Cheng Jiu-Mei ◽

...

Keyword(s):

Abdominal Wall ◽

High Intensity ◽

Clinical Analysis ◽

Abdominal Wall Endometriosis ◽

Ultrasound Ablation ◽

Focussed Ultrasound

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Recurrent cutaneous leiomyosarcoma of the anterior abdominal wall: a rare tumor at an unusual site

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20170805 ◽

2017 ◽

Vol 3 (1) ◽

pp. 151

Author(s):

Jyoti Rajpoot ◽

Sonam Sharma ◽

Rashmi Arora

Keyword(s):

Soft Tissue ◽

Abdominal Wall ◽

Rare Case ◽

Anterior Abdominal Wall ◽

Soft Tissue Sarcomas ◽

Clinicopathological Features ◽

Rare Tumor ◽

Prognostic Implication ◽

Unusual Site

<p class="abstract">Cutaneous leiomyosarcomas are uncommon neoplasms, accounting for 1-3% of all the soft tissue sarcomas. They encompass a variety of clinicopathological features that makes their diagnosis difficult. They are divided into various categories, as this division has an important prognostic implication. We describe a rare case of recurrent cutaneous leiomyosarcoma of the anterior abdominal wall in a 50 years old female. </p>

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Clinical analysis of bone metastasis of gastric cancer: incidence, clinicopathological features and survival

Future Oncology ◽

10.2217/fon-2019-0039 ◽

2019 ◽

Vol 15 (19) ◽

pp. 2241-2249

Author(s):

Lei Wen ◽

Yi-Ze Li ◽

Jing Zhang ◽

Cheng Zhou ◽

Hai-Nan Yang ◽

...

Keyword(s):

Gastric Cancer ◽

Bone Metastasis ◽

Cancer Incidence ◽

Clinical Analysis ◽

Clinicopathological Features

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Clinical analysis of congenital abdominal wall defects - omphalocele and gastroschisis

Medicinski pregled ◽

10.2298/mpns0608347t ◽

2006 ◽

Vol 59 (7-8) ◽

pp. 347-355 ◽

Cited By ~ 1

Author(s):

Milanka Tatic ◽

Radoica Jokic ◽

Svetlana Bukarica ◽

Vladimir Borisev

Keyword(s):

Birth Weight ◽

Abdominal Wall ◽

Gestational Age ◽

Intestinal Resection ◽

Intestinal Atresia ◽

Clinical Analysis ◽

Abdominal Wall Defects ◽

Mechanical Ileus ◽

Management Protocol ◽

Congenital Abdominal Wall Defects

Introduction. This is a retrospective analysis of therapeutic approaches and treatment outcomes of congenital abdominal wall defects (omphalocele and gastroschisis) in a five year period. The aim of this study was to identify factors which can affect the prognosis of future therapeutic procedures. Material and methods. We evaluated 13 children, 7 with omphalocele (2 female/5 male; mean birth weight of 2862 g; mean gestational age of 37 weeks), and 6 patients with gastroschisis (2 female/4 male; mean birth weight of 2640 g; mean gestational age of 36/2 weeks). All patients were treated at the Clinic of Pediatric Surgeiyfrom 1999 to 2003. Results. In this study, thirteen cases of congenital abdominal wall defects (omphalocele and gastroschisis) were retrospectively investigated. All patients underwent prenatal ultrasound. Omphalocele was prenatally detected in 42.8% of fetuses, and gastroschisis in 16.7%. Coexisting anomalies were present in 57.1% of patients with omphalocele and in 16.7% of newborns with gastroschisis. Three patients with omphalocele were treated operatively, and four only conservatively. The abdominal wall of patients with gastroschisis was primarily closed in three patients. Two patients required a staged abdominal wall closure. One patient with gastroschisis and intestinal atresia underwent primary closure after partial intestinal resection and enterostomy. Based on these responses, a management protocol (algorithm) was recommended. The most common postoperative complication, in 7 cases of omphalocele, was mechanical ileus (n=l), whereas among patients with gastroschisis the commonest were mechanical ileus (n=l) and intestinal perforation (n=1). The mortality of patients with omphalocele was 52% and with gastroschisis 66.7%. Conclusion. A strategy designed to optimize antenatal and neonatal factors is expected to increase the survival rate of patients with abdominal wall defects. .

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Clinicopathological Characteristics And Prognostic Factors For The Recurrence Of Abdominal Desmoid Tumors: Analysis Of 113 Patients From Two Chinses Hospitals

10.21203/rs.3.rs-41652/v1 ◽

2020 ◽

Author(s):

Sicheng Zhou ◽

Zhen Sun ◽

Jianwei Liang ◽

Zhixiang Zhou ◽

Xishan Wang

Keyword(s):

Prognostic Factors ◽

Local Recurrence ◽

Abdominal Wall ◽

Abdominal Cavity ◽

Clinicopathological Features ◽

Cancer Center ◽

Desmoid Tumors ◽

Clinicopathologic Characteristics ◽

High Local Recurrence Rate

Abstract Background and purpose: Abdominal desmoid tumors (ADTs) are rare soft-tissue neoplasms that have a relatively high local recurrence rate. The purpose of the present study was to delineate the clinicopathologic features and explore the prognostic factors of ADTs.Methods: From January 2000 to January 2019, patients with ADTs who underwent macroscopically complete resection at the China National Cancer Center were included in the study. The clinicopathologic characteristics and follow-up data were carefully collected and reviewed. Prognostic factors such as age at presentation, sex, tumor location, tumor size and tumor proximity to nerves or vasculature were analyzed, and recurrence-free survival was analyzed with these factors.Results: A total of 113 patients with ADTs were assigned to the abdominal wall group (n = 66) or abdominal cavity group (n = 47) according to the tumor site. Abdominal wall DTs and intra-abdominal DTs demonstrated distinct clinicopathological features and prognoses. During a median 61-month follow-up period, twelve (10.2%) patients had local recurrence. According to the univariate and multivariate analyses, intra-abdominal tumors, large tumors, and positive margins were independent risk factors for poor prognosis.Conclusion: Compared with intra-abdominal DTs, abdominal wall DTs demonstrate different clinicopathological features and a better prognosis. Under the premise of ensuring negative margins during the first surgical procedure, patients with abdominal wall DTs can obtain satisfactory prognoses through radical resection.

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